Skip to main content
SpringerLink
Log in

Assessment of left atrial function using speckle tracking echocardiography in ankylosing spondylitis: a case-control study

  • Original paper
  • Published:
The International Journal of Cardiovascular Imaging Aims and scope Submit manuscript

Abstract

The aim of this study is to assess the left atrium (LA) deformation parameters by using 2D speckle tracking echocardiography (2D-STE) in ankylosing spondylitis (AS) patients and to evaluate the relationship between these parameters and AS clinical indexes. 30 patients with AS (22 males, 8 females) and 30 healthy individuals (19 males, 11 females) were enrolled in this study. Transthoracic echocardiography was performed to both groups. Besides the conventional echocardiographic parameters, the LA strain parameters; including systolic-reservoir (LA S-S), early diastolic-conduit (LA S-E), late diastolic-contraction (LA S-A) were measured. No significant difference was found between two groups in terms of conventional echocardiographic parameters except mean deceleration time (DT). Mean DT was prolonged in the AS patients compare with the control group (173.5 ± 22.5 vs. 155.3 ± 36.7, p = 0.025). In the AS patients, LA S-S (48.3 ± 9.4 vs. 56.9 ± 10.1, p = 0.001), LA S-E (26.4 ± 6.4 vs. 31.6 ± 7.3, p = 0.005) and LA S-A (21.9 ± 4.7 vs. 25.4 ± 5.7, p = 0.013) values were statistically lower than the control group. Also a negative correlation was observed between the Bath Ankylosing Spondylitis Metrology Index (BASMI) and LA S-S (r = − 0.509, p = 0.004), LA S-E (r = − 0.501, p = 0.005). Our study demonstrated that 2D-STE is a useful method to determine the left atrial involvement in AS patients without the clinical evident of cardiovascular disease.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1

Similar content being viewed by others

References

  1. Lehtinen K (1993) Mortality and causes of death in 398 patients admitted to hospital with ankylosing spondylitis. Ann Rheum Dis 52:174–176

    Article  CAS  Google Scholar 

  2. Sieper J, Braun J, Rudwaleit M, Boonen A, Zink A (2002) Ankylosing spondylitis: an overview. Ann Rheum Dis 61:iii8–iii18

    Article  Google Scholar 

  3. Lautermann D, Braun J (2002) Ankylosing spondylitis-cardiac manifestations. Clin Exp Rheumatol 20:11–15

    Google Scholar 

  4. Ustun N, Kurt M, Nacar AB, Karateke HP, Guler H, Turhanoglu AD (2015) Left ventricular systolic dysfunction in patients with ankylosing spondylitis without clinically overt cardiovascular disease by speckle tracking echocardiography. Rheumatol Int 35:607–611

    Article  Google Scholar 

  5. Crowley JJ, Donnelly SM, Tobin M, FitzGerald O, Bresnihan B, Maurer BJ et al (1993) Doppler echocardiographic evidence of left ventricular diastolic dysfunction in ankylosing spondylitis. Am J Cardiol 71:1337–1340

    Article  CAS  Google Scholar 

  6. Brewerton DA, Gibson DG, Goddard DH, Jones TJ, Moore RB, Pease CT et al (1987) The myocardium in ankylosing spondylitis. A clinical, echocardiographic, and histopathological study. Lancet 1:995–998

    Article  CAS  Google Scholar 

  7. Gould BA, Turner J, Keeling DH, Hickling P, Marshall AJ (1992) Myocardial dysfunction in ankylosing spondylitis. Ann Rheum Dis 51:227–232

    Article  CAS  Google Scholar 

  8. Mor-Avi V, Lang RM, Badano LP, Belohlavek M, Cardim NM, Derumeaux G et al (2011) Current and evolving echocardiographic techniques for the quantitative evaluation of cardiac mechanics: ASE/EAE consensus statement on methodology and indications endorsed by the Japanese Society of Echocardiography. J Am Soc Echocardiogr 24:277–313

    Article  Google Scholar 

  9. Altekin RE, Yanikoglu A, Karakas MS, Ozel D, Kucuk M, Yilmaz H et al (2012) Assessment of left atrial dysfunction in obstructive sleep apnea patients with the two dimensional speckle-tracking echocardiography. Clin Res Cardiol 101:403–413

    Article  Google Scholar 

  10. Rudwaleit M, van der Heijde D, Landewé R, Listing J, Akkoc N, Brandt J et al (2009) The development of assessment of spondylo arthritis international society classification criteria for axial spondyloarthritis (part II): validation and final selection. Ann Rheum Dis 68:777–783

    Article  CAS  Google Scholar 

  11. Garrett S, Jenkinson T, Kennedy LG, Whitelock H, Gaisford P, Calin A (1994) A new approach to defining disease status in ankylosing spondylitis: the Bath Ankylosing Spondylitis Disease Activity Index. J Rheumatol 21:2286–2291

    CAS  PubMed  Google Scholar 

  12. Calin A, Garrett S, Whitelock H, Kennedy LG, O’Hea J, Mallorie P et al (1994) A new approach to defining functional ability in ankylosing spondylitis: the development of the Bath Ankylosing Spondylitis Functional Index. J Rheumatol 21:2281–2285

    CAS  PubMed  Google Scholar 

  13. Jenkinson TR, Mallorie PA, Whitelock HC, Kennedy LG, Garrett SL, Calin A (1994) Defining spinal mobility in ankylosing spondylitis (AS). The Bath AS Metrology Index. J Rheumatol 21:1694–1698

    CAS  PubMed  Google Scholar 

  14. Roman MJ, Salmon JE (2007) Cardiovascular manifestations of rheumatologic diseases. Circulation 116:2346–2355

    Article  Google Scholar 

  15. Moyssakis I, Gialafos E, Vassiliou VA, Boki K, Votteas V, Sfikakis PP et al (2009) Myocardial performance and aortic elasticity are impaired in patients with ankylosing spondylitis. Scand J Rheumatol 38:216–221

    Article  CAS  Google Scholar 

  16. O’Neill TW, Bresnihan B (1992) The heart in ankylosing spondylitis. Ann Rheum Dis 51:705–706

    Article  Google Scholar 

  17. Kvalvik AG, Jones MA, Symmons DP (2000) Mortality in a cohort of Norwegian patients with rheumatoid arthritis followed from 1977 to 1992. Scand J Rheumatol 29:29–37

    Article  CAS  Google Scholar 

  18. Prior P, Symmons DP, Scott DL, Brown R, Hawkins CF (1984) Cause of death in rheumatoid arthritis. Br J Rheumatol 23:92–99

    Article  CAS  Google Scholar 

  19. Goodson NJ, Wiles NJ, Lunt M, Barret EM, Silman AJ, Symmons DP (2002) Mortality in early inflammatory polyarthritis: cardiovascular mortality is increased in seropositive patients. Arthritis Rheum 46:2010–2019

    Article  Google Scholar 

  20. Finkel MS, Oddis CV, Jacob TD, Watkins SC, Hattler BG, Simmons RL (1992) Negative inotropic effects of cytokines on the heart mediated by nitric oxide. Science 257:387–389

    Article  CAS  Google Scholar 

  21. Hirota H, Yoshida K, Kishimoto T, Taga T (1995) Continuous activation of gp130, a signal-transducing receptor component for interleukin 6-related cytokines, causes myocardial hypertrophy in mice. Proc Natl Acad Sci USA 92:4862–4866

    Article  CAS  Google Scholar 

  22. Di Salvo G, Caso P, Lo Piccolo R, Fusco A, Martiniello AR, Russo MG et al (2005) Atrial myocardial deformation properties predict maintenance of sinus rhythm after external cardioversion of recent-onset lone atrial fibrillation: a color Doppler myocardial imaging and transthoracic and transesophageal echocardiographic study. Circulation 112:387–395

    Article  Google Scholar 

  23. Stefanadis C, Dernellis J, Toutouzas P (2001) A clinical appraisal of left atrial function. Eur Heart J 22:22–36

    Article  CAS  Google Scholar 

  24. Chen Y, Chung HY, Zhao CT, Wong A, Zhen Z, Tsang HH et al (2015) Left ventricular myocardial dysfunction and premature atherosclerosis in patients with axial spondyloarthritis. Rheumatology 54:292–301

    Article  CAS  Google Scholar 

  25. Acar G, Sayarlioglu M, Akcay A, Sokmen A, Sokmen G, Altun B et al (2009) Assessment of atrial electromechanical coupling characteristics in patients with ankylosing spondylitis. Echocardiography 26:549–557

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Cardiology, Faculty of Medicine, Akdeniz University, Antalya, Turkey

    Murathan Kucuk & İbrahim Basarici

  2. Department of Cardiology, Medical Park Hospital, Antalya, Turkey

    Necmettin Korucuk

  3. Department of Cardiology, Sanliurfa Education and Research Hospital, Yenice Boulevard, Sanliurfa, Turkey

    Veysel Tosun

  4. Department of Rheumatology, Faculty of Medicine, Akdeniz University, Antalya, Turkey

    Mediha Cavusoglu

Authors
  1. Murathan Kucuk
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Necmettin Korucuk
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Veysel Tosun
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Mediha Cavusoglu
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. İbrahim Basarici
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Veysel Tosun.

Ethics declarations

Conflict of interest

The authors declare that they have no conflict of interest.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Kucuk, M., Korucuk, N., Tosun, V. et al. Assessment of left atrial function using speckle tracking echocardiography in ankylosing spondylitis: a case-control study. Int J Cardiovasc Imaging 34, 1863–1868 (2018). https://doi.org/10.1007/s10554-018-1411-4

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10554-018-1411-4

Keywords

Search

Navigation