Incremental predictive value of carotid arterial strain in patients with stroke

  • Woo-In Yang
  • Ki-Woon Kang
  • Hye Young Lee
  • Chi-Young Shim
  • Geu-Ru Hong
  • Namsik Chung
  • Jong-Won Ha
Original Paper

Abstract

Although increased carotid intima-media thickness (IMT) is a well-known risk factor for stroke, carotid IMT alone is not sufficient for risk stratification. The assessment of arterial properties using velocity vector imaging (VVI) represents a new method for quantifying structural changes. We sought to investigate the characteristics and the clinical value of carotid arterial mechanics using VVI in patients with stroke. Fifty male patients (55 ± 5 years) with stroke, 30 healthy age-matched volunteers (54 ± 8 years), and 30 healthy young male volunteers (29 ± 5 years) were evaluated. The peak circumferential strain, strain rate, and the standard deviation of the time to peak strain and strain rate, representing the synchronicity of the arterial expansion, were analyzed using VVI of the left common carotid artery. The circumferential strain and strain rate significantly decreased with age, and patients with stroke showed the lowest degree of strain and strain rate compared with healthy age-matched volunteers. In addition, patients with stroke showed decreased strain and strain rate even in participants with a normal carotid IMT (< 0.8 mm). Although carotid IMT did not improve the incremental predictive value of stroke over that of multiple clinical risk factors (diabetes mellitus, hypertension, coronary artery disease, smoking), adding carotid arterial strain and strain rate provided an incremental predictive value over both multiple risk factors and carotid IMT for stroke. Along with assessment of conventional risk factors, VVI analysis could provide improved risk stratification for stroke.

Keywords

Carotid artery Stroke Ultrasound Velocity vector imaging 

Notes

Acknowledgements

This work was supported by a Korea Science and Engineering Foundation (KOSEF) grant funded by the Korean government (M10642120001-06N4212-00110).

Compliance with ethical standards

Conflict of interest

The authors of this article reported no actual or potential conflicts of interest in relation to this activity.

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Copyright information

© Springer Science+Business Media B.V., part of Springer Nature 2018

Authors and Affiliations

  • Woo-In Yang
    • 1
  • Ki-Woon Kang
    • 2
  • Hye Young Lee
    • 2
  • Chi-Young Shim
    • 2
  • Geu-Ru Hong
    • 2
  • Namsik Chung
    • 2
  • Jong-Won Ha
    • 2
    • 3
  1. 1.Department of Cardiology, CHA Bundang Medical CenterCHA UniversitySungnamRepublic of Korea
  2. 2.Cardiology Division, Severance Cardiovascular HospitalYonsei University College of MedicineSeoulRepublic of Korea
  3. 3.Cardiology Division, Severance Biomedical Science InstituteYonsei University College of MedicineSeoulRepublic of Korea

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