Accuracy of coronary computed tomography angiography for bioresorbable scaffold luminal investigation: a comparison with optical coherence tomography

  • Carlos Collet
  • Yohei Sotomi
  • Rafael Cavalcante
  • Taku Asano
  • Yosuke Miyazaki
  • Erhan Tenekecioglu
  • Pieter Kistlaar
  • Yaping Zeng
  • Pannipa Suwanasson
  • Robbert J. de Winter
  • Koen Nieman
  • Patrick W. Serruys
  • Yoshinobu Onuma
Original Paper

Abstract

To establish the accuracy of coronary computed tomography angiography (CTA) for in-scaffold quantitative evaluation with optical coherence tomography (OCT) as a reference. The translucent backbone of the bioresorbable scaffold allow us to evaluate non-invasively the coronary lumen with coronary CTA. In the ABSORB first-in-man studies, coronary CTA was shown to be feasible for quantitative luminal assessment. Nevertheless, a comparison with an intravascular modality with higher resolution has never been performed. In the ABSORB Cohort B trial, 101 patient with non-complex lesions were treated with the fully biodegradable vascular scaffold. For this analysis, all patients who underwent coronary CTA at 18 months and OCT within ±180 days were included. Coronary CTA and OCT data were analysed at an independent core laboratory for quantitative cross-sectional luminal dimensions. The primary objective was the accuracy and precision of coronary CTA for in-scaffold minimal lumen area assessment, with OCT as a reference. Among the 101 patients of the ABSORB Cohort B trial, 35 underwent both OCT and coronary CTA. The feasibility of quantitative evaluation was 74%. In the scaffolded segment, coronary CTA underestimated minimal lumen area by 9.8% (accuracy 0.39 mm2, precision 1.0 mm2, 95% limits of agreement −1.71 to 2.50 mm2). A similar level of agreement was observed in the non-scaffolded segment. Compared to OCT, coronary CTA appears to be accurate for the estimation of in-scaffold luminal areas, with no difference compared to the non-scaffolded region.

Keywords

Coronary computed tomography angiography Polymeric scaffolds Optical coherence tomography 

Abbreviations

BVS

Bioresobable vascular scaffold

CTA

Computed tomography angiography

IVUS

Intravascular ultrasound

FFRCT

Fractional flow reserve derived from computed tomography

OCT

Optical coherence tomography

PCI

Percutaneous coronary interventions

PLLA

Poly-l-lactide

Notes

Compliance with ethical standards

Conflict of interest

Y. Onuma and P.W. Serruys are members of International Advisory Board of Abbott Vascular. Y. Sotomi is a consultant for GOODMAN and has received a grant from the Fukuda Memorial Foundation and SUNRISE laboratory. P.H. Kitslaar is an employee of Medis medical imaging systems and has a research appointment at the Leiden University Medical Center. All other authors declare no competing interests.

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Copyright information

© Springer Science+Business Media Dordrecht 2016

Authors and Affiliations

  • Carlos Collet
    • 1
  • Yohei Sotomi
    • 1
  • Rafael Cavalcante
    • 2
  • Taku Asano
    • 1
  • Yosuke Miyazaki
    • 2
  • Erhan Tenekecioglu
    • 2
  • Pieter Kistlaar
    • 3
    • 4
  • Yaping Zeng
    • 2
  • Pannipa Suwanasson
    • 5
  • Robbert J. de Winter
    • 1
  • Koen Nieman
    • 2
  • Patrick W. Serruys
    • 6
  • Yoshinobu Onuma
    • 2
    • 7
  1. 1.Cardiology DepartmentAcademic Medical CentreAmsterdamThe Netherlands
  2. 2.ThoraxCenterErasmus University Medical CentreRotterdamThe Netherlands
  3. 3.Division of Image Processing, Department of RadiologyLeiden UniversityLeidenThe Netherlands
  4. 4.Medis medical imaging systems BVLeidenThe Netherlands
  5. 5.Northern Region Heart Center, Faculty of MedicineChiang Mai UniversityChiang MaiThailand
  6. 6.Imperial College of LondonLondonUK
  7. 7.Cardialysis BVRotterdamThe Netherlands

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