Association between bicuspid aortic valve morphotype and regional dilatation of the aortic root and trunk

  • Karam M. Habchi
  • Elena Ashikhmina
  • Vanessa Montiero Vieira
  • Jasmin T. Shahram
  • Eric M. Isselbacher
  • Thoralf M. SundtIII
  • Prem Shekar
  • Jochen D. Muehlschlegel
  • Bicuspid Aortic Valve Consortium
  • Simon C. Body
Original Paper

Abstract

Thoracic aortic disease, including thoracic aortic aneurysm (TAA), is frequently seen in patients with bicuspid aortic valve (BAV). We hypothesized that BAV morphotype would be associated with aortic aneurysm phenotypes but that other patient variables would significantly modify this relationship. 829 patients between 18 and 90 years with BAV and available raw imaging of the aortic valve and the ascending aorta to its mid-portion prior to aortic valve and aortic surgery were examined. The sinuses of Valsalva and proximal ascending aorta were measured from 2-dimensional co-planar echocardiographic images. We observed strong associations between patient habitus and raw and normalized dimensions of the aortic root and ascending aorta. Patients with R–L morphotype presented at an older age with larger aortic root but similar ascending aortic dimensions. After accounting for patient morphometric characteristics and severity of aortic valve disease, patients with R–L valve morphotype were marginally more likely to have an aortic root aneurysm (86% vs. 78%; P = 0.043), defined as aortic root dimension Z score ≥3. We observed only small differences in aortic dimensions between BAV morphotypes, that are eclipsed by variation in patient habitus. We interpret these findings to mean that BAV patients will not likely benefit from therapies based on aortic valve morphotype. Rather, we propose that all BAV patients should undergo longitudinal follow-up, independent of valve morphotype. Guidelines for aortic surgery based upon dimensions alone may be improved by considering patient characteristics such as age, body size and other characteristics.

Keywords

Aortic valve/*abnormalities/surgery Bicuspid aortic valve Ascending aorta Aortic aneurysm Prognosis 

Abbreviations

IE

Infective endocarditis

BAV

Bicuspid aortic valve

TAV

Tricuspid aortic valve

Notes

Funding

This work was funded by NIH Grants R01HL114823 (SCB) and R01HL118266 (JDM).

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the Institutional Review Board and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. The Institutional Review Board determined that individual patient consent was not required.

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Copyright information

© Springer Science+Business Media Dordrecht 2016

Authors and Affiliations

  • Karam M. Habchi
    • 1
  • Elena Ashikhmina
    • 2
  • Vanessa Montiero Vieira
    • 1
  • Jasmin T. Shahram
    • 1
  • Eric M. Isselbacher
    • 3
  • Thoralf M. SundtIII
    • 3
  • Prem Shekar
    • 4
  • Jochen D. Muehlschlegel
    • 1
  • Bicuspid Aortic Valve Consortium
    • 1
  • Simon C. Body
    • 1
  1. 1.Department of Anesthesiology, Perioperative and Pain MedicineBrigham and Women’s HospitalBostonUSA
  2. 2.Department of AnesthesiologyMayo ClinicRochesterUSA
  3. 3.Department of SurgeryMassachusetts General HospitalBostonUSA
  4. 4.Department of SurgeryBrigham and Women’s HospitalBostonUSA

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