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The International Journal of Cardiovascular Imaging

, Volume 30, Issue 7, pp 1365–1372 | Cite as

Comparative study of CMR characteristics between arrhythmogenic right ventricular cardiomyopathy patients with/without syncope

  • Huaibing Cheng
  • Minjie Lu
  • Cuihong Hou
  • Xuhua Chen
  • Jing Wang
  • Li Li
  • Junyi Wan
  • Gang Yin
  • Jianmin Chu
  • Sanjay K. Prasad
  • Shu Zhang
  • Jielin Pu
  • Shihua Zhao
Original Paper

Abstract

To compare cardiovascular magnetic resonance (CMR) characteristics between arrhythmogenic right ventricular cardiomyopathy (ARVC) patients with syncope and without syncope and explore CMR parameters related with syncope. A consecutive series of 80 patients with ARVC were divided in two groups according to history of syncope prior to CMR examinations. The biventricular function and volumes were calculated and indexed by body surface area. Fatty infiltration and late-gadolinium enhancement (LGE) were self-quantitatively analyzed according to segmental model. Patients with syncope had statistically significant greater left ventricular end-diastolic volume index (LVEDVI) (79.6 ± 23.0 vs. 69.0 ± 17.9 mL/m2, P = 0.030), right ventricular end-diastolic volume index (RVEDVI) (122.0 ± 30.0 vs. 107.4 ± 21.8 mL/m2, P = 0.017), and LGE incidence (52.2 vs. 21.1 %, P = 0.006) than that of patients without syncope. Patients with syncope had a trend towards greater number of segments with LGE (8.6 ± 4.2 vs. 6.6 ± 3.1, P = 0.199) than that of patients without syncope in subgroup analyses of patients with LGE, but no statistical significance was reached. Multivariate regression analysis showed the presence of LGE was independently associated with syncope in patients with ARVC (odds ratios 8.827, 95 % confidence interval 1.945–40.068, P = 0.005). CMR is helpful in detection and management of the patients with ARVC. Patients with syncope had significantly higher LVEDVI, RVEDVI and LGE incidence, and larger studies with follow-up data are needed to elucidate the relationship between LGE and syncope in patients with ARVC.

Keywords

Arrhythmogenic right ventricular cardiomyopathy Cardiovascular magnetic resonance Late-gadolinium enhancement Syncope 

Notes

Acknowledgments

The authors thank the staff and members of the departments of radiology, echocardiography, electrocardiogram and pathology for their assistance in various measurements, diagnosis, and other organizational aspects of this study.

This study was supported by Grants No. 81130029 from the key projects of National Natural Science Foundation of China and No. 2013CB531105 from National Basic Research Program of China (973 program projects).

Conflict of interest

None.

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Copyright information

© Springer Science+Business Media Dordrecht 2014

Authors and Affiliations

  • Huaibing Cheng
    • 1
  • Minjie Lu
    • 2
  • Cuihong Hou
    • 1
  • Xuhua Chen
    • 1
  • Jing Wang
    • 1
  • Li Li
    • 3
  • Junyi Wan
    • 2
  • Gang Yin
    • 2
  • Jianmin Chu
    • 1
  • Sanjay K. Prasad
    • 4
  • Shu Zhang
    • 1
  • Jielin Pu
    • 1
  • Shihua Zhao
    • 2
  1. 1.Center for Arrhythmia Diagnosis and Treatment, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical SciencesPeking Union Medical CollegeBeijingPeople’s Republic of China
  2. 2.Department of Radiology, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical SciencesPeking Union Medical CollegeBeijingPeople’s Republic of China
  3. 3.Department of Pathology, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical SciencesPeking Union Medical CollegeBeijingPeople’s Republic of China
  4. 4.NIHR Biomedical Research UnitRoyal Brompton HospitalLondonUnited Kingdom

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