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Comparative study of CMR characteristics between arrhythmogenic right ventricular cardiomyopathy patients with/without syncope

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Abstract

To compare cardiovascular magnetic resonance (CMR) characteristics between arrhythmogenic right ventricular cardiomyopathy (ARVC) patients with syncope and without syncope and explore CMR parameters related with syncope. A consecutive series of 80 patients with ARVC were divided in two groups according to history of syncope prior to CMR examinations. The biventricular function and volumes were calculated and indexed by body surface area. Fatty infiltration and late-gadolinium enhancement (LGE) were self-quantitatively analyzed according to segmental model. Patients with syncope had statistically significant greater left ventricular end-diastolic volume index (LVEDVI) (79.6 ± 23.0 vs. 69.0 ± 17.9 mL/m2, P = 0.030), right ventricular end-diastolic volume index (RVEDVI) (122.0 ± 30.0 vs. 107.4 ± 21.8 mL/m2, P = 0.017), and LGE incidence (52.2 vs. 21.1 %, P = 0.006) than that of patients without syncope. Patients with syncope had a trend towards greater number of segments with LGE (8.6 ± 4.2 vs. 6.6 ± 3.1, P = 0.199) than that of patients without syncope in subgroup analyses of patients with LGE, but no statistical significance was reached. Multivariate regression analysis showed the presence of LGE was independently associated with syncope in patients with ARVC (odds ratios 8.827, 95 % confidence interval 1.945–40.068, P = 0.005). CMR is helpful in detection and management of the patients with ARVC. Patients with syncope had significantly higher LVEDVI, RVEDVI and LGE incidence, and larger studies with follow-up data are needed to elucidate the relationship between LGE and syncope in patients with ARVC.

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Acknowledgments

The authors thank the staff and members of the departments of radiology, echocardiography, electrocardiogram and pathology for their assistance in various measurements, diagnosis, and other organizational aspects of this study.

This study was supported by Grants No. 81130029 from the key projects of National Natural Science Foundation of China and No. 2013CB531105 from National Basic Research Program of China (973 program projects).

Conflict of interest

None.

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Authors and Affiliations

  1. Center for Arrhythmia Diagnosis and Treatment, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, Peking Union Medical College, No. 167 Beilishi Road, Beijing, 100037, People’s Republic of China

    Huaibing Cheng, Cuihong Hou, Xuhua Chen, Jing Wang, Jianmin Chu, Shu Zhang & Jielin Pu

  2. Department of Radiology, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, Peking Union Medical College, No. 167 Beilishi Road, Beijing, 100037, People’s Republic of China

    Minjie Lu, Junyi Wan, Gang Yin & Shihua Zhao

  3. Department of Pathology, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, 100037, People’s Republic of China

    Li Li

  4. NIHR Biomedical Research Unit, Royal Brompton Hospital, Sydney Street, London, SW3 6NP, United Kingdom

    Sanjay K. Prasad

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  1. Huaibing Cheng
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Correspondence to Jielin Pu or Shihua Zhao.

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Cheng, H., Lu, M., Hou, C. et al. Comparative study of CMR characteristics between arrhythmogenic right ventricular cardiomyopathy patients with/without syncope. Int J Cardiovasc Imaging 30, 1365–1372 (2014). https://doi.org/10.1007/s10554-014-0481-1

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  • DOI: https://doi.org/10.1007/s10554-014-0481-1

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