Optical coherence tomographic comparison of neointimal coverage between sirolimus- and resolute zotarolimus-eluting stents at 9 months after stent implantation

  • Jung-Sun Kim
  • Jin-Sun Kim
  • Dong-Ho Shin
  • Byeong-Keuk Kim
  • Young-Guk Ko
  • Donghoon Choi
  • Yangsoo Jang
  • Myeong-Ki Hong
Original paper


The Resolute zotarolimus-eluting stent (ZES-R) has a thinner stent strut with biocompatible polymer than first generation drug-eluting stents. However, minimal optical coherence tomography (OCT) data exists about vascular responses after ZES-R implantation. This study investigated OCT findings in ZES-R implantation and compared them to those in sirolimus-eluting stent (SES) implantation. A total of 123 lesions (43 ZES-R and 80 SES) in 111 patients were evaluated with OCT at 9 months after stent implantation. Strut apposition, neointimal hyperplasia (NIH) thickness, and stent coverage on each stent strut were evaluated. Mean NIH thickness was significantly greater in ZES-R-treated lesions than in SES-treated lesions (166 ± 73 μm vs. 96 ± 63 μm, respectively, P < 0.001). The percentage of uncovered strut was significantly lower in ZES-R-treated lesions than in SES-treated lesions (4.4 ± 4.8% vs. 10.3 ± 13.2%, respectively, P = 0.05). The percentage of malapposed struts was also significantly lower in ZES-R-treated than in SES-treated lesions (0.1 ± 0.4% vs. 1.5 ± 4.2%, respectively, P = 0.002). Intracoronary thrombus was less frequently detected in ZES-R-treated lesions (4.7% vs. 30.0%, respectively, P = 0.001). ZES-R showed a lower incidence of uncovered or malapposed stent struts and intracoronary thrombus than SES at 9-month follow-up OCT examination. Compared with SES, ZES-R may elicit more favorable vascular responses at the expense of an increased neointimal proliferation.


Optical coherence tomography Stent 



The authors thank Hyun Sun Lim, PhD, of the Medical Research Support Section at the Yonsei University College of Medicine for statistical support. This study was partly supported by grants from the Korea Healthcare Technology R&D Project, Ministry for Health, Welfare & Family Affairs, Republic of Korea (No. A085012 and A102064), the Korea Health 21 R&D Project, Ministry of Health & Welfare, Republic of Korea (No. A085136), and the Cardiovascular Research Center, Seoul, Korea.

Conflict of interest



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Copyright information

© Springer Science+Business Media, B.V. 2011

Authors and Affiliations

  • Jung-Sun Kim
    • 1
  • Jin-Sun Kim
    • 1
  • Dong-Ho Shin
    • 1
  • Byeong-Keuk Kim
    • 1
  • Young-Guk Ko
    • 1
  • Donghoon Choi
    • 1
  • Yangsoo Jang
    • 1
    • 2
  • Myeong-Ki Hong
    • 1
    • 2
  1. 1.Division of Cardiology, Severance Cardiovascular HospitalYonsei University College of MedicineSeodaemun-gu, SeoulKorea
  2. 2.Severance Biomedical Science InstituteYonsei University College of MedicineSeoulKorea

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