Abstract
Coronary artery calcium (CAC) accumulation, a marker of atherosclerosis burden, differs significantly among patients of different ethnicities. It has been proposed that CAC scores can be used to assess the number of life years lost or gained by an individual with a given amount of coronary artery calcium. Therefore, we sought to develop a method to calculate the coronary age of an individual based on the extent of CAC in this subject compared to that of individuals of the same race, age and sex. We used median CAC scores from previously published data from the Multi-Ethnic Study of Atherosclerosis (MESA) to derive the predicted coronary age of subjects from 4 ethnic groups (White, Black, Hispanic and Chinese) of both sexes. With this method a 50-year-old white man with a CAC score of 40 has a coronary age of a 61-year-old white man; for a black man with a score of 40 the coronary age is 70. This method should allow patients to better understand the prognostic significance of their test results and may ensure a better compliance with preventive regimens.
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References
Agatston AS, Janowitz WR, Hildner FJ et al (1990) Quantification of coronary artery calcium using ultrafast computed tomography. J Am Coll Cardiol 15:827–832
Arad Y, Goodman KJ, Roth M, Newstein D, Guerci AD (2005) Coronary calcification, coronary disease risk factors, C-reactive protein, and atherosclerotic cardiovascular disease events: the St Francis Heart Study. J Am Coll Cardiol 46:158–165
Raggi P, Callister TQ, Cooil B et al (2000) Identification of patients at increased risk of first unheralded acute myocardial infarction by electron-beam computed tomography. Circulation 101:850–855
Greenland P, LaBree L, Azen SP, Doherty TM, Detrano RC (2004) Coronary artery calcium score combined with Framingham score for risk prediction in asymptomatic individuals. JAMA 291:210–215
Bild DE, Detrano R, Peterson D et al (2005) Ethnic differences in coronary calcification: the Multi-Ethnic Study of Atherosclerosis (MESA). Circulation 111:1313–1320
McClelland RL, Chung H, Detrano R et al (2006) Distribution of coronary artery calcium by race, gender, and age: results from the Multi-Ethnic Study of Atherosclerosis (MESA). Circulation 113:30–37
Bild DE, Bluemke DA, Burke GL et al (2002) Multi-ethnic study of atherosclerosis: objectives and design. Am J Epidemiol 156:871–881
Shaw LJ, Raggi P, Berman DS et al (2006) Coronary artery calcium as a measure of biologic age. Atherosclerosis 188:112–119
Detrano RC, Anderson M, Nelson J et al (2005) Coronary calcium measurements: effect of CT scanner type and calcium measure on rescan reproducibility-MESA study. Radiology 236:477–484
Raggi P, Cooil B, Callister TQ (2001) Use of electron beam tomography data to develop models for prediction of hard coronary events. Am Heart J 141:375–382
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Sirineni, G.K.R., Raggi, P., Shaw, L.J. et al. Calculation of coronary age using calcium scores in multiple ethnicities. Int J Cardiovasc Imaging 24, 107–111 (2008). https://doi.org/10.1007/s10554-007-9233-9
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DOI: https://doi.org/10.1007/s10554-007-9233-9