Three-dimensional recovery time dispersion map by 64-channel magnetocardiography may demonstrate the location of a myocardial injury and heterogeneity of repolarization
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QT dispersion reveals heterogeneities in the repolarization time in the three-dimensional (3D) structure of the ventricular myocardium. In this study, we report on a 3D function map of recovery time (RT) dispersions as measured by 64-channel magnetocardiography (MCG).
MCG were simultaneously recorded in 29 controls and 21 patients with previous myocardial infarction (MI). The 3D current density was calculated from 64-channel MCG data in the B z component using a space filter. The heart outline, reconstructed from the integrated the current density, revealed both the atrium and ventricle. The RT for the intervals between QRS onset and the time of the maximum dT/dt of T wave, and the peak to the end of the T wave (Tpeak-negative dT/dt) were automatically measured by means of a computer from 3D MCG data. The corrected RT (RTc) and corrected Tpeak-negative dT/dt were then calculated using Bazett’s formula. The 3D RTc and the corrected Tpeak-negative dT/dt dispersion map were superimposed on the heart outline generated by MCG.
The RTc was significantly longer for the MI group than in the control group (67±25 ms1/2 vs. 16±6 ms1/2) (p<0.0001). The corrected Tpeak-negative dT/dt dispersions in each patient was also significantly longer for the MI group than in the control group (35±27 ms1/2 vs. 10±5 ms1/2) (p<0.0001). Furthermore, the 3D RTc and Tpeak-negative dT/dt dispersion maps corresponded with the space location of MI, as defined by Tc-99m tetrofosmin myocardial imaging
3D RTc and Tpeak-negative dT/dt dispersion maps in the ST segment, obtained by 64-channel MCG may be used demonstrate the location of a myocardial injury and heterogeneities of repolarization.
Keywordselectric current density map heterogeneities of repolarization magnetocardiography myocardial injury RT-dispersion
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This study was supported by a grant from the Joint Research Project for Regional Intensive in Iwate Prefecture, the Keiryokai Foundation (No.88) of Iwate Medical University, and Open Research Translational Research Center Project, Advanced Medical Science Center, Iwate Medical University.
- 1.Cohen D, Edelsack EA, Zimmaerman JE. (1970). Magnetocardiogram taken inside a shielded room with superconducting point-contact magnetometor. Appl Phys 16:288–94Google Scholar
- 4.Nakai K, Kawazoe K, Izumoto H, et al. Construction of a 3D outline of the heart and conduction pathway by means of a 64-channel magnetocardiogram in patients with atrial flutter and fibrillation. Int J Cardiovasc Imaging 2005; 21: 555–561Google Scholar
- 9.Tikhonov AN, Arsenin VY. The regurarization method. In: Solution of III-Posed Problems. Washington, DC: VH Winstin & Sons, 1977; 45–94Google Scholar
- 10.Pasola K, Nenonen J, Proceedings of 12th International Conference on Biomagnetism 2001, 835–838Google Scholar
- 15.Matsuo K, Shimizu W, Kurita T, Suyama K, Aihara N, Kamakura S, Shimomura K. (1998). Increased dispersion of repolarization time determined by monophasic action potentials in two patients with familial idiopathic ventricular fibrillation. J Cardiovasc Electrophysiol 9:74–83PubMedCrossRefGoogle Scholar