Relationship of extent and nature of dysfunctional myocardium to brain natriuretic peptide in patients with ischemic left ventricular dysfunction

  • Charles A. Nelson
  • Colin Case
  • Jane McCrohon
  • Thomas H. Marwick


We studied the relationship between brain natriuretic peptide (BNP) levels and viable myocardium and ischemic myocardium, regional scar and regional contractile function. Fifty-nine patients underwent dobutamine echocardiography and magnetic resonance imaging and resting BNP levels were determined. By magnetic resonance imaging, total extent of dysfunctional myocardium correlated strongest with BNP (r = 0.60, p < 0.0001). The extent of scar, viability and ischemia also correlated. At dobutamine echocardiography, a composite of dysfunctional and ischemic myocardium was the strongest correlate of BNP (r = 0.48, p < 0.0001), with less strong correlations by global parameters. The extent of dysfunctional myocardium, rather than its nature determines BNP levels.


echocardiography stress magnetic resonance imaging myocardial infarction natriuretic peptide ventricular dysfunction 



brain natriuretic peptide


dobutamine echocardiography


magnetic resonance imaging


creatinine clearance


LV systolic global wall stress


end diastolic volume


end systolic volume


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Copyright information

© Springer 2005

Authors and Affiliations

  • Charles A. Nelson
    • 1
  • Colin Case
    • 1
  • Jane McCrohon
    • 2
  • Thomas H. Marwick
    • 1
  1. 1.Department of MedicineUniversity of Queensland, Princess Alexandra HospitalBrisbaneAustralia
  2. 2.St. George HospitalSydneyAustralia

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