Organochlorine pesticides and prostate cancer, Is there an association? A meta-analysis of epidemiological evidence
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The results of epidemiological studies about exposure to organochlorine pesticides (OCPs) and risk of prostate cancer (PC) are inconclusive. We conducted a meta-analysis to evaluate the association between exposure to specific OCPs and PC.
We searched PubMed, Scopus, and Web of science databases for case–control and cohort studies published till March 2015 that provided data about exposure to OCPs and PC. We also contacted authors and hand-searched references of the included articles. We calculated pooled estimates using random effects model and explored heterogeneity between studies.
We systematically reviewed 15 articles and based our meta-analysis on 10 articles covering nine case–control studies and a large prospective cohort study. Pooled estimates of PC for highest versus lowest exposed category to p,p′-DDE was 1.02 (0.69–1.35), I 2 = 12.7 %, p = 0.333, trans-nonachlor, 0.88 (0.45–1.31), I 2 = 0.00 %, p = 0.892, oxychlordane, 0.91 (0.46–1.35), hexachlorobenzene, 0.88 (0.18–1.57), I 2 = 36.0 %, p = 0.210 from combining results of studies that applied serum OCPs measurements among the general population. For DDT, stratifying studies by exposed population revealed homogeneity, pooled estimate for serum level measurement for the highest exposed versus the lowest exposed of the general population was 0.81 (0.95–1.26), I 2 = 0.00 %, p = 0.400, and for occupational exposure 1.30 (0.94–1.67), I 2 = 13.4 %, p = 0.315. A positive but also insignificant association was obtained for pooling results for high exposure to lindane among farmers and pesticide applicators, 1.56 (0.82–2.29), I 2 = 41.7 %, p = 0.180.
The existing epidemiological data do not support the hypothesis that exposure to specific OCPs is associated with an increased incidence of PC in the general population.
KeywordsOrganochlorine pesticides Prostate cancer Meta-analysis Epidemiology
Agricultural Health Study
Environmental Protection Agency
International Agency of Research on Cancer
Job exposure matrix
Standardized incidence ratio
This paper is part of the Ph.D. work of A.M.L.M. It presents independent research commissioned by the European Union and reflects the view only of the author. The commission cannot be held responsible for any use which may be made of the information contained therein.
A.M.L.M. conducted the searches, reviewed the papers, interpreted the analysis and contributed to the writing of the manuscript. A.B.C. contributed to the design of the study, reviewing of the papers, interpretation of the analysis, and writing of the manuscript. R.O.R. contributed to the searching and reviewing of the papers. V.M.R. contributed to the reviewing of the papers. J.J.J.M. designed the search strategy, contributed to the reviewing of the papers, interpretation of the analysis, and the writing of the manuscript. All authors have read and approved the submission of the manuscript.
This project has been funded with support of the European Commission (Erasmus Mundus scholarship).
Compliance with ethical standard
Conflict of interest
- 5.IARC (2012) IARC monographs on the evaluation of carcinogenic risks to humans Volume 100F. A review of human carcinogens: chemical agents and related occupations. International Association for Research on Cancer (IARC), LyonGoogle Scholar
- 6.De Coster S, van Larebeke N (2012) Endocrine-disrupting chemicals: associated disorders and mechanisms of action. J Environ Pub Health 713696Google Scholar
- 14.Shah S, Hess-Wilson JK, Webb S et al (2008) 2,2-bis(4-chlorophenyl)-1,1-dichloroethylene stimulates androgen independence in prostate cancer cells through combinatorial activation of mutant androgen receptor and mitogen-activated protein kinase pathways. Mol Cancer Res 6:1507–1520CrossRefPubMedGoogle Scholar
- 29.Wells G, Shea B, O’Connell D, Peterson J, Welch V et al (2013) The Newcastle–Ottawa scale (NOS) for assessing the quality of non-randomized studies in meta-analysis. http://www.ohri.ca/programs/clinical_epidemiology/oxford.asp. Accessed 10/09/2014
- 31.Borenstein M, Hedges LV, Higgins J, Rothstein HR (2010) A basic introduction to fixed-effect and random-effects models for meta-analysis. Res Synth Methods 1:97–111Google Scholar
- 44.Emeville E, Giusti A, Coumoul X, Thomé JP, Blanchet P, Multigner L (2014) Associations of plasma concentrations of dichlorodiphenyldichloroethylene and polychlorinated biphenyls with prostate cancer: a case–control study in guadeloupe (French West Indies). Environ Health Perspect. doi: 10.1289/ehp.1408407
- 45.Koutros S, Langseth H, Grimsrud TK, Barr DB, Vermeulen R, Portengen L, Wacholder S, Beane Freeman LE, Blair A, Hayes RB, Rothmann N, Engel LS (2015) Prediagnostic serum organochlorine concentrations and metastatic prostate cancer: a nested case–control study in the Norwegian Janus Serum Bank Cohort. Environ Health Perspect. doi: 10.1289/ehp.1408245 PubMedGoogle Scholar
- 63.Nieuwenhuijsen MJ (2010) Exposure assessment in occupational and environmental epidemiology. Oxford University Press, OxfordGoogle Scholar