Cancer Causes & Control

, Volume 26, Issue 9, pp 1339–1349 | Cite as

Residential exposure to solar ultraviolet radiation and incidence of childhood hematological malignancies in France

  • Astrid Coste
  • Stéphanie Goujon
  • Mathieu Boniol
  • Fabienne Marquant
  • Laure Faure
  • Jean-François Doré
  • Denis Hémon
  • Jacqueline Clavel
Original paper



Few studies have investigated the relationship between solar ultraviolet radiation (UV) and childhood hematological malignancies (CHM). This study addresses the associations between residential UV exposure at diagnosis and the incidence of types and subtypes of CHM, by age and gender, in France, over a long period, on the fine scale of the 36,326 Communes that constitute mainland France.


The 9,082 cases of acute leukemia and 3,563 cases of lymphoma diagnosed before the age of 15 years from 1990 to 2009 were provided by the French National Registry of Childhood Hematological Malignancies. The incidence of CHM was calculated by Commune, year, age and gender and expressed as the standardized incidence ratio (SIR). UV data from 1988 to 2007 were extracted from the EUROSUN database.


The annual daily average UV exposure of the children ranged from 85.5 to 137.8 J/cm2. For each additional 25 J/cm2, there was a significant increase in precursor B-cell acute lymphoblastic leukemia (PBC-ALL) in children aged less than 5 years (SIR 1.18; 95 % CI 1.10–1.27). Further analysis of PBC-ALL in the young children suggested a better fit of models with a threshold, with the risk increasing above 100 J/cm2, for which the SIR was 1.24 (95 % CI 1.14–1.36) for a 25 J/cm2 increase. The results remained stable in analyses stratifying by deprivation index or degree of urbanization of the Communes.


The study suggests that higher residential UV exposure may be positively associated with a higher incidence of PBC-ALL in early childhood.


Ultraviolet radiation Sun exposure Children Hematological malignancies 





Childhood hematological malignancies


Acute leukemia


Acute lymphoblastic leukemia


Acute myeloid leukemia


Precursor B-cell acute lymphoblastic leukemia


Non-Hodgkin’s lymphoma


Hodgkin’s lymphoma



This study was supported by the ‘Institut de Veille Sanitaire’ (InVS), ‘Agence Nationale de Sécurité Sanitaire de l’Alimentation, de l’Environnement et du Travail’ (ANSES; EST-2013/1/205), ‘Association pour la recherche sur le cancer’ (ARC), ‘Institut National du Cancer’ (INCa), which provided financial support to the ‘Plateforme de recherche sur les cancers de l’enfant,’ ‘Agence Nationale de la Recherche’ (ANR) and ‘Cancéropôle Ile-de-France.’ It is part of the ‘Investissement d’Avenir’ HOPE-EPI program supported by the ANR. The authors are particularly grateful to all the NRCH research assistants who collected the cases’ data and the pediatric oncology teams for their help in data collection.

Supplementary material

10552_2015_629_MOESM1_ESM.docx (60 kb)
Supplementary material 1 (DOCX 59 kb)


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Copyright information

© Springer International Publishing Switzerland 2015

Authors and Affiliations

  • Astrid Coste
    • 1
  • Stéphanie Goujon
    • 1
    • 2
  • Mathieu Boniol
    • 3
  • Fabienne Marquant
    • 1
  • Laure Faure
    • 1
    • 2
  • Jean-François Doré
    • 4
  • Denis Hémon
    • 1
  • Jacqueline Clavel
    • 1
    • 2
  1. 1.INSERM, UMR1153 Epidemiology and Biostatistics Sorbonne Paris Cité Research Center (CRESS), Epidemiology of Chilhood and Adolescent Cancers Team (EPICEA)Paris Descartes UniversityVillejuifFrance
  2. 2.French National Registry of Childhood Hematological Malignancies (NRCH)VillejuifFrance
  3. 3.Institute of Global Public Health at iPRI, International Prevention Research InstituteUniversity of StrathclydeLyonFrance
  4. 4.Cancer Research Center of Lyon (CRCL), INSERM UMR 1052 CNRS 52B6Centre Léon BérardLyon Cedex 08France

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