Residential exposure to solar ultraviolet radiation and incidence of childhood hematological malignancies in France
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Few studies have investigated the relationship between solar ultraviolet radiation (UV) and childhood hematological malignancies (CHM). This study addresses the associations between residential UV exposure at diagnosis and the incidence of types and subtypes of CHM, by age and gender, in France, over a long period, on the fine scale of the 36,326 Communes that constitute mainland France.
The 9,082 cases of acute leukemia and 3,563 cases of lymphoma diagnosed before the age of 15 years from 1990 to 2009 were provided by the French National Registry of Childhood Hematological Malignancies. The incidence of CHM was calculated by Commune, year, age and gender and expressed as the standardized incidence ratio (SIR). UV data from 1988 to 2007 were extracted from the EUROSUN database.
The annual daily average UV exposure of the children ranged from 85.5 to 137.8 J/cm2. For each additional 25 J/cm2, there was a significant increase in precursor B-cell acute lymphoblastic leukemia (PBC-ALL) in children aged less than 5 years (SIR 1.18; 95 % CI 1.10–1.27). Further analysis of PBC-ALL in the young children suggested a better fit of models with a threshold, with the risk increasing above 100 J/cm2, for which the SIR was 1.24 (95 % CI 1.14–1.36) for a 25 J/cm2 increase. The results remained stable in analyses stratifying by deprivation index or degree of urbanization of the Communes.
The study suggests that higher residential UV exposure may be positively associated with a higher incidence of PBC-ALL in early childhood.
KeywordsUltraviolet radiation Sun exposure Children Hematological malignancies
Childhood hematological malignancies
Acute lymphoblastic leukemia
Acute myeloid leukemia
Precursor B-cell acute lymphoblastic leukemia
This study was supported by the ‘Institut de Veille Sanitaire’ (InVS), ‘Agence Nationale de Sécurité Sanitaire de l’Alimentation, de l’Environnement et du Travail’ (ANSES; EST-2013/1/205), ‘Association pour la recherche sur le cancer’ (ARC), ‘Institut National du Cancer’ (INCa), which provided financial support to the ‘Plateforme de recherche sur les cancers de l’enfant,’ ‘Agence Nationale de la Recherche’ (ANR) and ‘Cancéropôle Ile-de-France.’ It is part of the ‘Investissement d’Avenir’ HOPE-EPI program supported by the ANR. The authors are particularly grateful to all the NRCH research assistants who collected the cases’ data and the pediatric oncology teams for their help in data collection.
- 4.INTERNATIONAL AGENCY FOR RESEARCH ON CANCER (1992) IARC monographs on the evaluation of carcinogenic risks to humans. Solar and ultraviolet radiation. IARC Monogr Eval Carcinog Risks Hum 55:1–316Google Scholar
- 7.International Programme on Chemical Safety (1994) Ultraviolet radiation. Environ Health Criteria (EHC) 160:1–157Google Scholar
- 31.Rey G, Jougla E, Fouillet A, Hémon D (2009) Ecological association between a deprivation index and mortality in France over the period 1997–2001: variations with spatial scale, degree of urbanicity, age, gender and cause of death. BMC Pub Health 9:33. doi: 10.1186/1471-2458-9-33 CrossRefGoogle Scholar