Cancer Causes & Control

, Volume 24, Issue 11, pp 1963–1972 | Cite as

Dietary aflatoxin B1 intake, genetic polymorphisms of CYP1A2, CYP2E1, EPHX1, GSTM1, and GSTT1, and gastric cancer risk in Korean

  • Sang-Yong Eom
  • Dong-Hyuk Yim
  • Yanwei Zhang
  • Jung-Kuk Yun
  • Sun In Moon
  • Hyo-Yung Yun
  • Young-Jin Song
  • Sei-Jin Youn
  • Taisun Hyun
  • Joo-Seung Park
  • Byung Sik Kim
  • Jong-Young Lee
  • Yong-Dae Kim
  • Heon Kim
Original Paper



We investigated the effects of aflatoxin B1 (AFB1) intake, genetic polymorphisms of AFB1 metabolic enzymes, and interactions between the polymorphisms and intake of AFB1 with regard to the risk of gastric cancer in Korean.


The participants in the study included 477 gastric cancer patients and 477 age- and sex-matched control subjects. Direct interviews and a structured questionnaire were used to determine the level of exposure to AFB1, and the GoldenGate assay and multiplex polymerase chain reaction were used for genotypic analyses of the cytochrome P450 1A2 (CYP1A2), cytochrome P450 1E1, epoxide hydrolase 1, and glutathione S-transferase genes.


The probable daily intake of AFB1 was significantly higher among gastric cancer patients than among control subjects (cases vs. controls: 1.91 ± 0.87 vs. 1.65 ± 0.72 ng/kg bw/day, p < 0.0001), and increased AFB1 intake was significantly associated with an elevated risk of gastric cancer (odds ratio 1.94; 95 % confidence interval 1.43–2.63). However, genetic polymorphisms of AFB1 metabolic enzymes were not associated with gastric cancer, with the exception of CYP1A2. Moreover, there was no interaction between AFB1 intake and the genotypes of metabolic enzymes that affect gastric cancer risk.


Our results suggest that dietary AFB1 exposure might be associated with a risk of gastric cancer. However, the effect of AFB1 on gastric carcinogenesis may not be modulated by genetic polymorphisms of AFB1 metabolic enzymes.


Gastric cancer Aflatoxin B1 Genetic polymorphism Cytochrome P450 1A2 Glutathione S-transferase Epoxide hydrolase 



This study was supported by a grant from the National R&D Program for Cancer Control, Ministry of Health & Welfare, Republic of Korea (1120330).

Conflict of interest



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Copyright information

© Springer Science+Business Media Dordrecht 2013

Authors and Affiliations

  • Sang-Yong Eom
    • 1
  • Dong-Hyuk Yim
    • 1
  • Yanwei Zhang
    • 1
  • Jung-Kuk Yun
    • 1
  • Sun In Moon
    • 1
  • Hyo-Yung Yun
    • 2
  • Young-Jin Song
    • 2
  • Sei-Jin Youn
    • 3
  • Taisun Hyun
    • 4
  • Joo-Seung Park
    • 5
  • Byung Sik Kim
    • 6
  • Jong-Young Lee
    • 7
  • Yong-Dae Kim
    • 1
  • Heon Kim
    • 1
  1. 1.Department of Preventive Medicine and Medical Research Institute, College of MedicineChungbuk National UniversityCheongjuKorea
  2. 2.Department of Surgery, College of MedicineChungbuk National UniversityCheongjuKorea
  3. 3.Department of Internal Medicine, College of MedicineChungbuk National UniversityCheongjuKorea
  4. 4.Department of Food and NutritionChungbuk National UniversityCheongjuKorea
  5. 5.Department of Surgery, College of MedicineEulji UniversityDaejonKorea
  6. 6.Department of Surgery, Asan Medical Center, College of MedicineUlsan UniversitySeoulKorea
  7. 7.Center for Genome ScienceNational Institute of HealthOsongKorea

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