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Childhood acute leukemia, maternal beverage intake during pregnancy, and metabolic polymorphisms

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An Erratum to this article was published on 21 June 2014

Abstract

Purpose

This study aimed to analyze the associations between childhood acute leukemia (AL) and maternal caffeinated beverage consumption during pregnancy, and to explore interactions between caffeinated and alcoholic beverage consumption and polymorphisms of enzymes involved in caffeine and ethanol metabolisms.

Methods

The data were generated by the French ESCALE study, which included 764 AL cases and 1,681 controls in 2003–2004. The case and control mothers were interviewed on their consumption habits during pregnancy using a standardized questionnaire. Genotypes of the candidate alleles (NAT2*5 rs1801280, ADH1C*2 rs698 and rs1693482, CYP2E1*5 rs2031920 and rs3813867) were obtained using high-throughput genotyping and imputation data for 493 AL cases and 549 controls with at least two grandparents born in Europe.

Results

Maternal regular coffee consumption during pregnancy was associated with childhood AL (OR = 1.2 [1.0–1.5], p = 0.02); the odds ratios increased linearly with daily intake (p for trend <0.001; >2 cups per day vs. no or less than 1 cup per week: AL: OR = 1.6 [1.2–2.1], lymphoblastic AL: OR = 1.5 [1.1–2.0], myeloblastic AL: OR = 2.4 [1.3–4.3]). The association was slightly more marked for children born to non-smoking mothers. Lymphoblastic AL was also associated with cola soda drinking (OR = 1.3 [1.0–1.5], p = 0.02). No significant gene–environment interactions with coffee, tea, cola soda, or alcohol drinking were observed.

Conclusion

This study provides additional evidence that maternal coffee consumption during pregnancy may be associated with childhood AL. Coffee consumption is a prevalent habit and its potential involvement in childhood AL needs to be considered further.

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Abbreviations

AL:

Acute leukemia

ALL:

Acute lymphoblastic leukemia

AML:

Acute myeloblastic leukemia

CEU:

Utah residents with Northern and Western European ancestry from the CEPH collection

CEPH:

Centre d’Etude du Polymorphisme Humain

CYP2E1:

Cytochrome P450 2E1

NAT2:

N-acetyltransferase 2

ADH:

Alcohol dehydrogenase

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Acknowledgments

The authors are grateful to Claire Mulot, who was in charge of the biological collection at the Biological Resource Center of Saints-Pères, INSERM U775; the CEPH and the Centre National du Génotypage, which genotyped the cases; and IntegraGen which genotyped the controls. The authors would also like to express their gratitude to Marie-Hélène Da Silva, Christophe Steffen, and Florence Menegaux (INSERM U1018, Environmental Epidemiology of Cancer), who contributed to the recruitment of the cases; Aurélie Guyot-Goubin and the staff of the French National Registry of Childhood Blood Malignancies, who contributed to case detection and verification; Sabine Mélèze and Marie-Anne Noel (Institut CSA), who coordinated the selection of the controls and the interviews; and Catherine Tricoche (Callson) and the team of interviewers, who interviewed the cases and controls. The authors would also like to thank all of the Société Française de lutte contre les Cancers de l’Enfant et de l’Adolescent (SFCE) principal investigators: André Baruchel (Hôpital Saint-Louis/Hôpital Robert Debré, Paris), Claire Berger (Centre Hospitalier Universitaire, Saint-Etienne), Christophe Bergeron (Centre Léon Bérard, Lyon), Jean-Louis Bernard (Hôpital La Timone, Marseille), Yves Bertrand (Hôpital Debrousse, Lyon), Pierre Bordigoni (Centre Hospitalier Universitaire, Nancy), Patrick Boutard (Centre Hospitalier Régional Universitaire, Caen), Gérard Couillault (Hôpital d’Enfants, Dijon), Christophe Piguet (Centre Hospitalier Régional Universitaire, Limoges), Anne-Sophie Defachelles (Centre Oscar Lambret, Lille), François Demeocq (Hôpital Hôtel-Dieu, Clermont-Ferrand), Alain Fischer (Hôpital des Enfants Malades, Paris), Virginie Gandemer (Centre Hospitalier Universitaire—Hôpital Sud, Rennes), Dominique Valteau-Couanet (Institut Gustave Roussy, Villejuif), Jean-Pierre Lamagnere (Centre Gatien de Clocheville, Tours), Françoise Lapierre (Centre Hospitalier Universitaire Jean Bernard, Poitiers), Guy Leverger (Hôpital Armand Trousseau, Paris), Patrick Lutz (Hôpital de Hautepierre, Strasbourg), Geneviève Margueritte (Hôpital Arnaud de Villeneuve, Montpellier), Françoise Mechinaud (Hôpital Mère et Enfants, Nantes), Gérard Michel (Hôpital La Timone, Marseille), Frédéric Millot (Centre Hospitalier Universitaire Jean Bernard, Poitiers), Martine Münzer (American Memorial Hospital, Reims), Brigitte Nelken (Hôpital Jeanne de Flandre, Lille), Hélène Pacquement (Institut Curie, Paris), Brigitte Pautard (Centre Hospitalier Universitaire, Amiens), Yves Perel (Hôpital Pellegrin Tripode, Bordeaux), Alain Pierre-Kahn (Hôpital Enfants Malades, Paris), Emmanuel Plouvier (Centre Hospitalier Régional, Besançon), Xavier Rialland (Centre Hospitalier Universitaire, Angers), Alain Robert (Hôpital des Enfants, Toulouse), Hervé Rubie (Hôpital des Enfants, Toulouse), Nicolas Sirvent (L’Archet, Nice), Christine Soler (Fondation Lenval, Nice), and Jean-Pierre Vannier (Hôpital Charles Nicolle, Rouen). This work was supported by the grants from INSERM, the Fondation de France, the Association pour la Recherche sur le Cancer (ARC), the Agence Française de Sécurité Sanitaire des Produits de Santé (AFSSAPS), the Agence Française de Sécurité Sanitaire de l’Environnement et du Travail (AFSSET), the association Cent pour sang la vie, the Institut National du Cancer (INCa), the Agence Nationale de la Recherche (ANR), and Cancéropôle Ile de France.

Author information

Authors and Affiliations

  1. Inserm, Centre for research in Epidemiology and Population Health (CESP), U1018, Environmental epidemiology of Cancer Group, 16, Avenue Paul Vaillant-Couturier, Bâtiment 15/16, 94807, Villejuif, France

    Audrey Bonaventure, Jérémie Rudant, Stéphanie Goujon-Bellec, Laurent Orsi, Denis Hémon & Jacqueline Clavel

  2. Univ Paris-Sud, UMRS 1018, 94807, Villejuif, France

    Audrey Bonaventure, Jérémie Rudant, Stéphanie Goujon-Bellec, Laurent Orsi, Denis Hémon & Jacqueline Clavel

  3. RNHE, National Registry of Childhood Hematopoietic Malignancies, Villejuif, France

    Jérémie Rudant, Stéphanie Goujon-Bellec & Jacqueline Clavel

  4. AP-HP, Hôpital Armand Trousseau, Paris, France

    Guy Leverger

  5. Université Paris 6 Pierre et Marie Curie, Paris, France

    Guy Leverger

  6. AP-HP, Hôpital Robert Debré, Paris, France

    André Baruchel

  7. Université Paris 7, Paris, France

    André Baruchel

  8. Institut d’Hémato-Oncologie Pédiatrique, Lyon, France

    Yves Bertrand

  9. Hôpital Jeanne de Flandre, CHRU, Lille, France

    Brigitte Nelken

  10. Université Lille Nord de France, 59000, Lille, France

    Brigitte Nelken

  11. Hôpital des Enfants, Toulouse, France

    Marlène Pasquet

  12. AP-HM, Hôpital la Timone, Marseille, France

    Gérard Michel

  13. Hôpital Arnaud de Villeneuve, Montpellier, France

    Nicolas Sirvent

  14. CHU de Nancy, Vandoeuvre, France

    Pierre Bordigoni

  15. Hematology and Oncology, Children’s Hospital, Pellegrin, Bordeaux University Hospital, Bordeaux, France

    Stéphane Ducassou

  16. Hôpital Mère-Enfant, CHU-Nantes, Nantes, France

    Xavier Rialland

  17. CHU d’Angers, Angers, France

    Xavier Rialland

  18. Commissariat à l’Energie Atomique (CEA) Genomics Institute-Centre National de Génotypage, Evry Cedex, France

    Diana Zelenika

Authors
  1. Audrey Bonaventure
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  2. Jérémie Rudant
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  3. Stéphanie Goujon-Bellec
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  4. Laurent Orsi
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  5. Guy Leverger
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  6. André Baruchel
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  8. Brigitte Nelken
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  9. Marlène Pasquet
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  10. Gérard Michel
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  11. Nicolas Sirvent
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  12. Pierre Bordigoni
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  13. Stéphane Ducassou
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  14. Xavier Rialland
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  15. Diana Zelenika
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  16. Denis Hémon
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  17. Jacqueline Clavel
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Corresponding author

Correspondence to Jérémie Rudant.

Additional information

An erratum to this article is available at http://dx.doi.org/10.1007/s10552-014-0403-5.

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Bonaventure, A., Rudant, J., Goujon-Bellec, S. et al. Childhood acute leukemia, maternal beverage intake during pregnancy, and metabolic polymorphisms. Cancer Causes Control 24, 783–793 (2013). https://doi.org/10.1007/s10552-013-0161-9

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