Cancer Causes & Control

, Volume 23, Issue 5, pp 727–735 | Cite as

Association of colorectal adenoma with components of metabolic syndrome

  • Byung Chang Kim
  • Aesun Shin
  • Chang Won Hong
  • Dae Kyung Sohn
  • Kyung Su Han
  • Kum Hei Ryu
  • Bum Joon Park
  • Ji Hyung Nam
  • Ji Won Park
  • Hee Jin Chang
  • Hyo Seong Choi
  • Jeongseon Kim
  • Jae Hwan Oh
Original paper



Recently, some studies have shown that diabetes mellitus and metabolic syndrome increase the risk of colorectal neoplasms. Although the mechanism is not known, those have been proposed to contribute to this phenomenon, including insulin resistance, oxidative stress, and adipokine production. The objective of this study was to assess the association between metabolic risk factors and colorectal neoplasm.


Study participants visited the National Cancer Center, Korea, for screening (2007–2009). A total of 1,771 diagnosed adenoma patients and 4,667 polyp-free controls were included. The association between risk factors and colorectal neoplasm was evaluated using logistic regression models.


High waist circumference, blood pressure, and serum triglyceride levels were associated with an increased risk of colorectal adenoma. Metabolic syndrome (MS) was associated with an increased risk of adenoma (OR = 1.44, 95 % CI = 1.23–1.70). The association between MS and colorectal adenoma was observed regardless of advanced/low-risk adenoma, and multiplicity. MS affected right colon adenomas (OR = 1.50, 95 % CI = 1.22–1.85), left colon adenomas (OR = 1.36, 95 % CI = 1.05–1.76), and adenomas in multiple anatomical locations (OR = 1.59, 95 % CI = 1.19–2.12), but was not associated with rectum.


Central obesity, triglyceride level, and MS are risk factors for colorectal adenoma including advanced adenoma and multiplicity.


Metabolic syndrome Colorectal neoplasm Obesity Triglyceride 



This study was supported in part by grants NCC-0910160 (H. J. C), NCC-0710360 (C. W. H), and NCC-0910220 (A. S) from the National Cancer Center, Korea. The authors thank Jeong-Hee Lee, MS for her help in manuscript preparation.

Conflicts of interest

None declared.

Supplementary material

10552_2012_9942_MOESM1_ESM.doc (99 kb)
Supplementary material 1 (DOC 99 kb)


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Copyright information

© Springer Science+Business Media B.V. 2012

Authors and Affiliations

  • Byung Chang Kim
    • 1
    • 2
  • Aesun Shin
    • 3
  • Chang Won Hong
    • 1
    • 2
    • 4
  • Dae Kyung Sohn
    • 1
    • 2
  • Kyung Su Han
    • 1
    • 2
  • Kum Hei Ryu
    • 2
  • Bum Joon Park
    • 2
  • Ji Hyung Nam
    • 2
  • Ji Won Park
    • 1
  • Hee Jin Chang
    • 1
  • Hyo Seong Choi
    • 1
  • Jeongseon Kim
    • 3
  • Jae Hwan Oh
    • 1
  1. 1.Center for Colorectal CancerResearch Institute and Hospital of National Cancer CenterGoyang-siKorea
  2. 2.Center for Cancer Prevention and DetectionHospital of National Cancer CenterGoyang-siKorea
  3. 3.Cancer Epidemiology BranchResearch Institute, National Cancer CenterGoyang-siKorea
  4. 4.Center for Colorectal Cancer, Center for Cancer Prevention and DetectionResearch Institute and Hospital, National Cancer CenterIlsandon-gu, Goyang-siRepublic of Korea

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