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Cancer Causes & Control

, Volume 23, Issue 12, pp 2041–2046 | Cite as

Reproductive history and risk of small bowel cancer by histologic type: a population-based study

  • Yunxia Lu
  • Mats Lambe
  • Anna Martling
  • Jesper Lagergren
Brief report

Abstract

Purpose

The male predominance of the two main histologic malignancies of the small bowel cancer may reflect a role of sex hormones which will be examined in this study.

Methods

This was a nationwide population-based nested case–control study, based on a cohort of subjects born between 1932 and 2008, as identified in the Swedish Multi-Generation Register. For each case of small bowel cancer, 10 age- and sex-matched controls were randomly selected. Number of children and age at having the first child were analyzed in relation to the risk of small bowel cancer using conditional logistic regression, providing odds ratios (ORs) and 95 % confidence intervals (CIs).

Results

A total of 632 female cases and 894 male cases of small bowel cancer were included. No overall increased risk of small bowel cancer was found in parous compared to non-parous women (OR = 1.02, 95 % CI 0.67–1.54). There was no association between age at first birth and small bowel cancer (>30 years of age vs <20 years; OR = 1.04, 95 % CI 0.72–1.50). No associations were detected in separate analyses of adenocarcinoma or carcinoid of the small bowel. No distinct risk patterns were discerned in men compared to women.

Conclusions

Reproductive history does not seem to be associated with the risk of small bowel cancer, independent of histologic type.

Keywords

Small bowel cancer Parity Age at first birth Adenocarcinoma Carcinoid 

Notes

Acknowledgments

The Swedish Research Council (SIMSAM) funded the study. We are also grateful for Sandra Eloranta’s comments for statistical analysis.

Conflict of interest

No potential competing interests to disclose.

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Copyright information

© Springer Science+Business Media Dordrecht 2012

Authors and Affiliations

  • Yunxia Lu
    • 1
  • Mats Lambe
    • 2
    • 3
  • Anna Martling
    • 4
  • Jesper Lagergren
    • 1
    • 5
  1. 1.Upper Gastrointestinal Research, Department of Molecular Medicine and SurgeryKarolinska InstitutetStockholmSweden
  2. 2.Department of Medical Epidemiology and BiostatisticsKarolinska InstitutetStockholmSweden
  3. 3.Regional Cancer CenterUniversity HospitalUppsalaSweden
  4. 4.Lower Gastrointestinal Research Group, Department of Molecular Medicine and SurgeryKarolinska InstitutetStockholmSweden
  5. 5.Division of Cancer StudiesKing’s College LondonLondonUK

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