Occupational risks and lung cancer burden for Chinese men: a population-based case–referent study
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We aimed to fill in the gap of knowledge on the lung cancer burden resulting from occupational exposures among Chinese men through a population-based case–referent study.
Detailed information on lifestyle and full occupational histories of 1,208 male lung cancer incident cases and 1,069 age-matched male community referents were obtained through interviews during 2004–2006. The associations between lung cancer risk and exposures to specific or group of agents that were confirmed or suspected occupational carcinogens were analyzed.
After adjustment of smoking and other potential confounding factors, significant odds ratio of lung cancer was observed for workers employed in major industrial divisions of “construction” (1.37, 95% CI: 1.00–1.89) and “financing, insurance, real estate, and business services” (0.48, 95% CI: 0.23–0.97), as well as in the occupational groups of “bricklayers, carpenters, and other construction workers” (1.49, 95% CI: 1.07–2.06). Significantly elevated odds ratios were found for occupational exposures to silica dust (1.75, 95% CI: 1.16–2.62), welding fumes (1.74, 95% CI: 1.13–2.68), diesel exhaust (2.18, 95% CI: 1.23–3.84), and man-made mineral fibers (7.45, 95% CI: 1.63–34.00), while a significantly reduced risk (OR = 0.67, 95% CI: 0.47–0.95) was linked to cotton dust. The population attributable fraction of lung cancer was 3.2% (95% CI: 0.1–7.3%) for construction workers and 9.5% (95% CI: 4.8–15.1%) for the four significant specific exposures.
Our study indicates that previous exposure to occupational carcinogens remains an important determinant of lung cancer burden for Hong Kong Chinese men. However, results obtained from this study should be confirmed by future analyses based on job exposure matrix.
KeywordsLung carcinoma Occupation Industry Carcinogen
Environmental tobacco smoke
International Standard Classification of Occupations
International Standard Industrial Classification of All Economic Activities
Man-made mineral fibers
- 95% CI
95% Confidence interval
Population attributable fraction
International Agency for Research on Cancer
Standardized mortality ratio
The work described in this paper was substantially supported by a grant from the Research Grants Council of the Hong Kong Special Administrative Region, China; Project No. CUHK4460/03M. The funding source had no role in the study design, data collection, data analysis, or interpretation of the findings.
Conflict of interest
The authors declared no conflicts of interest.
- 1.International Agency of Research on Cancer (2004) IARC monographs on the evaluation of carcinogenic risks to humans, vol 83 Tobacco smoke and Involuntary smoking. IARC Press, LyonGoogle Scholar
- 11.International Labour Office (1968) International standard classifications of occupations, 2nd edn. International Labour Office Publications, GenevaGoogle Scholar
- 12.United Nations Publications (1971) International standard industrial classification of all economic activities (ISIC). Publishing Service United Nations, New YorkGoogle Scholar
- 15.International Agency for Research on Cancer (1997) IARC monographs on the evaluation of carcinogenic risks to human, silica, some silicates, coal dust, and para-aramid fibrils, vol 68. IARC Publications, LyonGoogle Scholar
- 16.IARC (1990) IARC monographs on the evaluation of carcinogenic risks to humans, vol 49, WELDING (Group 2B). IARC Press, LyonGoogle Scholar
- 17.IARC (2009) Diesel and gasoline engine exhausts and some nitroarenes, IARC Monographs Volume 46. http://monographs.iarc.fr/ENG/Monographs/vol46/volume46.pdf. Accessed 11 Dec 2009
- 18.RC IA (1988) IARC monographs on the evaluation on the carcinogenetic risks to humans. vol 43: Man-made mineral fibers and radon. IARC, LyonGoogle Scholar
- 19.RC IA (1989) IARC monographs on the evaluation of carcinogenic risks to humans Polynuclear aromatic compounds, engine, exhausts and nitroarenes. International Agency for Research on Cancer, LyonGoogle Scholar
- 20.McDonald C, Cherry N (1999) Crystalline silica and lung cancer: the problem of conflicting evidence. Indoor Built Environ 8:121–126Google Scholar
- 35.Census Statistics Department Hong Kong Government (2010) 2009 Report on annual earnings and hours survey. http://www.legco.gov.hk/yr09-10/chinese/panels/mp/papers/mp0323-rpt100318-ec.pdf [Accessed on 26 November, 2010]