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Association of serum 25-hydroxyvitamin D (25-OHD) concentrations with maternal sex steroids and IGF-1 hormones during pregnancy

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Abstract

Background

Vitamin D may influence circulating levels of sex steroid hormones in women during reproductive life, but associations in pregnant women have not been explored.

Methods

Correlation and linear regression models were used to assess the association between sex steroids, (estradiol, progesterone, 17-hydroxyprogesterone, testosterone, and androstenedione), IGF-1, and serum 25-hydroxyvitamin D (25-OHD) concentrations during the first trimester of pregnancy in 106 cancer-free women from the Finnish Maternity Cohort.

Results

There was no significant association of serum 25-OHD with any of the hormones measured. One-unit increase in serum 25-OHD concentration was associated with a non-significant 6% increase in estradiol concentrations. Multiparous women had higher levels of vitamin D (40.4 vs. 32.9 nmol/L, p-value = 0.01) than primiparous women.

Conclusion

Our study does not support an association between maternal serum 25-OHD levels and sex steroids or IGF-I concentrations during the first trimester of pregnancy.

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Acknowledgments

Supported by grant number CA120061 from the US National Cancer Institute. Adetunji T Toriola was supported by an EACR (European Association for Cancer Research) Travel Fellowship Award to visit the Department of Cancer Epidemiology, German Cancer Research Centre, Heidelberg.

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Authors and Affiliations

  1. National Institute for Health and Welfare, PL 310, 90101, Oulu, Finland

    Adetunji T. Toriola & Helja-Marja Surcel

  2. Department of Cancer Epidemiology, German Cancer Research Centre, Heidelberg, Germany

    Anika Husing, Helena Schock & Annekatrin Lukanova

  3. Department of Medical Biosciences, Umeå University, Umeå, Sweden

    Kjell Grankvist, Hans-Ake Lakso & Eva Lundin

  4. Tampere School of Public Health, University of Tampere, Tampere, Finland

    Matti Lehtinen

  5. Department of Obstetrics and Gynaecology, New York University School of Medicine, New York, NY, USA

    Annekatrin Lukanova

Authors
  1. Adetunji T. Toriola
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  2. Helja-Marja Surcel
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  3. Anika Husing
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  4. Kjell Grankvist
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  5. Hans-Ake Lakso
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  6. Helena Schock
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  7. Eva Lundin
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  8. Matti Lehtinen
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  9. Annekatrin Lukanova
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Corresponding author

Correspondence to Adetunji T. Toriola.

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Toriola, A.T., Surcel, HM., Husing, A. et al. Association of serum 25-hydroxyvitamin D (25-OHD) concentrations with maternal sex steroids and IGF-1 hormones during pregnancy. Cancer Causes Control 22, 925–928 (2011). https://doi.org/10.1007/s10552-011-9752-5

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  • DOI: https://doi.org/10.1007/s10552-011-9752-5

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