Systemic folate status and risk of colorectal cancer
In their recent study of plasma folate concentration and risk of colorectal cancer (CRC), Otani et al.  concluded that a folate-rich status did not reduce the risk of CRC. The authors discussed several limitations of their study, including the low response rate for donation of a blood sample (23% for male cohort participants), the relative merits of measuring plasma folate concentration (a rather transient measure compared to erythrocyte folate), the relevance of current rather than past folate status and the low number of folate-deficient subjects in their study population; these are all valid caveats in the interpretation of this study. However, the description of the impact of methylene tetrahydrofolate reductase (MTHFR) gene polymorphisms was inaccurate. The authors state that the homozygous variant genotype is associated with an increased risk of CRC and a reduced enzymatic activity; they cite the work of Ma et al.  to support these statements. Firstly, the direction of the...
KeywordsColorectal Cancer Folate Ulcerative Colitis Folate Intake Methylene Tetrahydrofolate
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