Cancer Causes & Control

, Volume 19, Issue 1, pp 107–114 | Cite as

Nested case–control study of occupational physical activity and prostate cancer among workers using a job exposure matrix

  • Anusha Krishnadasan
  • Nola Kennedy
  • Yingxu Zhao
  • Hal Morgenstern
  • Beate Ritz
Original Paper



We conducted a nested case–control study of 362 cases diagnosed between 1 January 1988 and 31 December 1999, and 1,805 matched controls to examine the association between occupational physical activity and prostate-cancer incidence among workers at a nuclear and rocket engine-testing facility in Southern California.


We obtained cancer incidence data from the California Cancer Registry and seven other state cancer registries. Data from company records were used to construct a job exposure matrix (JEM) for occupational physical activity during employment. Conditional logistic regression was used to estimate associations.


With adjustment for occupational confounders, including socioeconomic status and trichloroethylene (TCE) exposure, high activity levels at work were inversely associated with prostate-cancer incidence among aerospace workers (odds ratio [OR] = 0.55; 95% CI = 0.32–0.95), but not among radiation workers (OR = 0.95; 95% CI = 0.43–2.1).


Our results suggest that adult men who are more continually active at work may have a decreased risk of prostate cancer.


Occupational physical activity Prostate cancer Job exposure matrix Nested case–control study 



We thank Kavitha Pathmarajah for help with data collection and entry, and the employees of the Rocketdyne/Boeing Company who provided valuable information about work conducted at the facility.


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Copyright information

© Springer Science+Business Media B.V. 2007

Authors and Affiliations

  • Anusha Krishnadasan
    • 1
    • 4
  • Nola Kennedy
    • 2
  • Yingxu Zhao
    • 1
  • Hal Morgenstern
    • 3
  • Beate Ritz
    • 1
    • 2
  1. 1.Department of EpidemiologySchool of Public Health, UCLALos AngelesUSA
  2. 2.Department of Environmental Health SciencesSchool of Public Health, UCLALos AngelesUSA
  3. 3.Department of EpidemiologySchool of Public Health, University of MichiganAnn ArborUSA
  4. 4.Department of Emergency MedicineOlive View-UCLA Medical CenterSylmarUSA

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