Skip to main content

Advertisement

SpringerLink
Log in

Urinary tract diseases and bladder cancer risk: a case–control study

  • Original Paper
  • Published:
Cancer Causes & Control Aims and scope Submit manuscript

Abstract

Objective

The role of urinary tract diseases in bladder cancer (BC) etiology is not well established. To gain more insight on the role of urinary tract diseases in bladder cancer risk, we analyzed data from a large case–control study of bladder cancer.

Methods

Epidemiological data were collected via in-person interview. Logistic regression analyses were used to estimate BC risk in association with prior history of urinary tract diseases.

Results

A total of 659 BC patients and 689 age-, gender-, -ethnicity matched controls were included in the analyses. Increased bladder cancer risk was associated with history of cystitis (OR = 1.52, 95% CI: 1.12, 2.06), however, the risk was attenuated for infections diagnosed >1 year from the time of BC diagnosis or interview. In contrast, a history of four or more kidney infections was associated with a significant decreased risk of BC (OR=0.17, 95% CI: 0.04, 0.69), and there was a significant dose-response relationship between number of episode and BC risk (P for trend = 0.002). The joint effect of smoking with cystitis, kidney infection, bladder stone, kidney stone, and prostate infection was studied but revealed no significant interaction between smoking and these urinary tract diseases.

Conclusion

This study does not support the concept that urinary tract infections play a major role in the development of BC. Our study has the strength of collecting diagnosis time data of urinary tract diseases to allow analyzing the impact of timing of diagnosis between cancer and urinary tract diseases. This enables us to effectively address the issue of detection bias in case–controls studies of prior urinary diseases and BC.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. American Cancer Society. Cancer Facts and Figures 2006. Available at http://www.cancer.org/docroot/STT/stt_0.asp

  2. Kirkali Z, Chan T, Manoharan M et al (2005) Bladder cancer: epidemiology, staging and grading, and diagnosis. Urology 66:4–34

    Article  PubMed  Google Scholar 

  3. Taioli E, Raimondi S (2005) Genetic susceptibility to bladder cancer. Lancet 366:610–612

    Article  PubMed  Google Scholar 

  4. Wu X, Gu J, Grossman HB et al (2006) Bladder cancer predisposition: a multigenic approach to DNA-repair and cell-cycle-control genes. Am J Hum Genet 78:464–479

    Article  PubMed  CAS  Google Scholar 

  5. Castellsagué X, Díaz M, de Sanjosé S et al (2006) Worldwide human papillomavirus etiology of cervical adenocarcinoma and its cofactors: implications for screening and prevention. J Natl Cancer Inst 98:303–315

    Article  PubMed  Google Scholar 

  6. Forman D (1998) Helicobacter pylori: the gastric cancer problem. Gut 43:S33–S34

    Article  PubMed  Google Scholar 

  7. Tsukuma H, Tanaka H, Ajiki W et al (2005) Liver cancer and its prevention. Asian Pac J Cancer Prev 6:244–250

    PubMed  Google Scholar 

  8. González CA, Errezola M, Izarzugaza I et al (1991) Urinary infection, renal lithiasis and bladder cancer in spain. Eur J Cancer 27:498–500

    Article  PubMed  Google Scholar 

  9. Kantor AF, Hartge P, Hoover RN et al (1984) Urinary tract infection and risk of bladder cancer. Am J Epidemiol 119:510–515

    PubMed  CAS  Google Scholar 

  10. Kjaer SK, Knudsen JB, Sørensen BL et al (1989) The copenhagen case–control study of bladder cancer. V. review of the role of urinary-tract infection. Acta Oncol 28:631–636

    PubMed  CAS  Google Scholar 

  11. La Vecchia C, Negri E, D’Avanzo B et al (1991) Genital and urinary tract diseases and bladder cancer. Cancer Res 51:629–631

    PubMed  CAS  Google Scholar 

  12. Khurana S, Dubey ML, Malla N (2005) Association of parasitic infections and cancers. Indian J Med Microbiol 23:74–79

    Article  PubMed  CAS  Google Scholar 

  13. Hess MJ, Zhan EH, Foo DK et al (2003) Bladder cancer in patients with spinal cord injury. J Spinal Cord Med 26:335–338

    PubMed  Google Scholar 

  14. Kaufman JM, Fam B, Jacobs SC et al (1997) Bladder cancer and squamous metaplasia in spinal cord injury patients. J Urol 118:967–971

    Google Scholar 

  15. van Velzen D, Krishnan KR, Parsons KF et al (1995) Comparative pathology of dome and trigone of urinary bladder mucosa in paraplegics and tetraplegics. Paraplegia 33:565–572

    PubMed  Google Scholar 

  16. Kunze E, Chang-Claude J, Frentzel-Beyme R (1992) Life style and occupational risk factors for bladder cancer in germany. A case–control study. Cancer 69:1776–1790

    Article  PubMed  CAS  Google Scholar 

  17. Piper JM, Matanoski GM, Tonascia J (1986) Bladder cancer in young women. Am J Epidemiol 123:1033–1042

    PubMed  CAS  Google Scholar 

  18. Dunham LJ, Rabson AS, Stewart HL et al (1968) Rates, interview, and pathology study of cancer of the urinary bladder in New Orleans, Louisiana. J Natl Cancer Inst 41:683–709

    PubMed  CAS  Google Scholar 

  19. Wynder EL, Onderdonk J, Mantel N (1963) An epidemiological investigation of cancer of the bladder. Cancer 16:1388–1407

    Article  PubMed  CAS  Google Scholar 

  20. Hudmon KS, Honn SE, Jiang H et al (1997) Identifying and recruiting healthy control subjects from a managed care organization: a methodology for molecular epidemiological case–control studies of cancer. Cancer Epidemiol Biomarkers Prev 6:565–571

    PubMed  CAS  Google Scholar 

  21. Howe GR, Burch JD, Miller AB et al (1980) Tobacco use, occupation, coffee, various nutrients, and bladder cancer. J Natl Cancer Inst 64:701–713

    PubMed  CAS  Google Scholar 

  22. Chow WH, Lindblad P, Gridley G et al (1997) Risk of urinary tract cancers following kidney or ureter stones. J Natl Cancer Inst 89:1453–1457

    Article  PubMed  CAS  Google Scholar 

Download references

Acknowledgment

This study was supported by the following grants: CA 74880 and CA 91846

Author information

Authors and Affiliations

  1. Department of Epidemiology, Unit 1340, The University of Texas M.D. Anderson Cancer Center, 1155 Hermann Pressler Blvd, Houston, TX, 77030, USA

    Manisha Jhamb, Jie Lin, Rebecca Ballow & Xifeng Wu

  2. Department of Urology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA

    Ashish M. Kamat & H. Barton Grossman

Authors
  1. Manisha Jhamb
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Jie Lin
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Rebecca Ballow
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Ashish M. Kamat
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. H. Barton Grossman
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Xifeng Wu
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Xifeng Wu.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Jhamb, M., Lin, J., Ballow, R. et al. Urinary tract diseases and bladder cancer risk: a case–control study. Cancer Causes Control 18, 839–845 (2007). https://doi.org/10.1007/s10552-007-9028-2

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10552-007-9028-2

Keywords

Search

Navigation