Cancer Causes & Control

, Volume 18, Issue 3, pp 305–313 | Cite as

Occupational exposure to low frequency magnetic fields and the risk of low grade and high grade glioma

  • Ken Kyriakos Karipidis
  • Geza Benke
  • Malcolm R. Sim
  • Michael Yost
  • Graham Giles
Original Paper



The purpose of this population-based case control study was to investigate a possible association between occupational exposure to low frequency magnetic fields and the risk of low grade glioma (LGG) and high grade glioma (HGG).


The study population consisted of 414 histologically confirmed cases of glioma (LGG = 110, HGG = 304), first diagnosed between July 1987 and December 1991, and 421 controls from Melbourne, Australia, matched by age, sex and postcode of residence. A detailed occupational history was obtained for each subject. Exposure to low frequency magnetic fields was estimated using three different methods: self-report, expert hygienist review and a job exposure matrix (JEM).


Elevated but statistically non-significant risk estimates were found for all glioma and HGG when exposure was assessed by the expert hygienist. The odds ratios (OR) for the highest exposed group of workers when assessed by the expert hygienist were 1.4 (95% confidence interval, CI: 0.85–2.27) and 1.51 (95% CI: 0.90–2.53) for all glioma and HGG, respectively. There were inverse associations for the self-reported and JEM exposures for both LGG and HGG but these may reflect limitations in these exposure assessment methods.


Our results do not support a role for occupational exposure to low frequency magnetic fields in the development of either LGG or HGG.


Low grade glioma High grade glioma Case–control study Magnetic fields Occupational exposure 



We thank all of the subjects who participated; the nurse interviewers, Ms J. Snaddon and Ms S. Gardiner; Ms L. Quango for computer programming assistance; and the participating neurosurgeons. This study was funded by grants from the National Health and Medical Research Council (NHMRC) of Australia, the Victorian Health Promotion Foundation and the Alfred Hospital.


  1. 1.
    Preston-Martin S, Staples M, Farrugia H, Giles G (1993) Primary tumors of the brain, cranial nerves and cranial meninges in Victoria, Australia, 1982–1990: patterns of incidence and survival. Neuroepidemiology 12:270–279PubMedGoogle Scholar
  2. 2.
    Ohgaki H, Kleihues P (2005) Epidemiology and etiology of gliomas. Acta Neuropathol (Berl) 109:93–108CrossRefGoogle Scholar
  3. 3.
    Kleihues P, Cavenee WK (2000) Pathology and genetics of tumours of the nervous system. International Agency for Research on Cancer, LyonGoogle Scholar
  4. 4.
    Wrensch M, Minn Y, Chew T, Bondy M, Berger MS (2002) Epidemiology of primary brain tumors: current concepts and review of the literature. Neuro-oncol 4:278–299PubMedCrossRefGoogle Scholar
  5. 5.
    Inskip PD, Linet MS, Heineman EF (1995) Etiology of brain tumors in adults. Epidemiol Rev 17:382–414PubMedGoogle Scholar
  6. 6.
    Kheifets LI, Afifi AA, Buffler PA, Zhang ZW (1995) Occupational electric and magnetic field exposure and brain cancer: a meta-analysis. J Occup Environ Med 37:1327–1341PubMedGoogle Scholar
  7. 7.
    Kheifets LI (2001) Electric and magnetic field exposure and brain cancer: a review. Bioelectromagnetics Suppl 5:S120–S131CrossRefGoogle Scholar
  8. 8.
    Savitz DA, Loomis DP (1995) Magnetic field exposure in relation to leukemia and brain cancer mortality among electric utility workers. Am J Epidemiol 141:123–134PubMedCrossRefGoogle Scholar
  9. 9.
    Miller AB, To T, Agnew DA, Wall C, Green LM (1996) Leukemia following occupational exposure to 60-Hz electric and magnetic fields among Ontario electric utility workers. Am J Epidemiol 144:150–160PubMedGoogle Scholar
  10. 10.
    Harrington JM, McBride DI, Sorahan T, Paddle GM, van Tongeren M (1997) Occupational exposure to magnetic fields in relation to mortality from brain cancer among electricity generation and transmission workers. Occup Environ Med 54:7–13PubMedGoogle Scholar
  11. 11.
    Johansen C, Olsen JH (1998) Risk of cancer among Danish utility workers – a nationwide cohort study. Am J Epidemiol 147:548–555PubMedGoogle Scholar
  12. 12.
    Savitz DA, Cai J, van Wijngaarden E, Loomis D, Mihlan G, Dufort V et al (2000) Case-cohort analysis of brain cancer and leukemia in electric utility workers using a refined magnetic field job-exposure matrix. Am J Ind Med 38:417–425PubMedCrossRefGoogle Scholar
  13. 13.
    International Commission on Non-Ionizing Radiation Protection (2003) Exposure to static and low frequency electromagnetic fields, biological effects and health consequences (0–100 kHz). ICNIRP, Oberschleibheim, pp 450–451Google Scholar
  14. 14.
    Giles GG, McNeil JJ, Donnan G, Webley C, Staples MP, Ireland PD et al (1994) Dietary factors and the risk of glioma in adults: results of a case–control study in Melbourne, Australia. Int J Cancer 59:357–362PubMedCrossRefGoogle Scholar
  15. 15.
    World Health Organization (1976) International classification of diseases for oncology (ICD-O). WHO, GenevaGoogle Scholar
  16. 16.
    Hurley SF (1990) Screening: the need for a population register. Med J Aust 153:310–311PubMedGoogle Scholar
  17. 17.
    International Labour Office (1969) International Standard classification of Occupations, 1968. ILO, GenevaGoogle Scholar
  18. 18.
    Noonan CW, Reif JS, Yost M, Touchstone J (2002) Occupational exposure to magnetic fields in case-referent studies of neurodegenerative diseases. Scand J Work Environ Health 28:42–48PubMedGoogle Scholar
  19. 19.
    Abdollahzadeh S, Hammond SK, Schenker MB (1995) A model for assessing occupational exposure to extremely low-frequency magnetic fields in fabrication rooms in the Semiconductor Health Study. Am J Ind Med 28:723–734PubMedCrossRefGoogle Scholar
  20. 20.
    Electric Power Research Institute (1992) Electric and magnetic field exposure, chemical exposure, and leukemia risk in “electrical” occupations. Technical Report No. 101723. EPRI, Palo AltoGoogle Scholar
  21. 21.
    Breysse PN, Matanoski GM, Elliott EA, Francis M, Kaune W, Thomas K (1994) 60 Hertz magnetic field exposure assessment for an investigation of leukemia in telephone lineworkers. Am J Ind Med 26:681–691PubMedGoogle Scholar
  22. 22.
    Floderus B, Persson T, Stenlund C, Wennberg A, Ost A, Knave B (1993) Occupational exposure to electromagnetic fields in relation to leukemia and brain tumors: a case–control study in Sweden. Cancer Causes Control 4:465–476PubMedCrossRefGoogle Scholar
  23. 23.
    Gobba F, Rossi P, Roccatto L (2003) [Levels of occupational exposure to extremely low frequency magnetic fields among workers in different jobs]. G Ital Med Lav Ergon 25:214–215PubMedGoogle Scholar
  24. 24.
    Touchstone J (1995) A comparison of EMF exposure assessment methods: on-site assessment versus a job exposure matrix. University of WashingtonGoogle Scholar
  25. 25.
    Swan SH, Waller K, Hopkins B, Windham G, Fenster L, Schaefer C et al (1998) A prospective study of spontaneous abortion: relation to amount and source of drinking water consumed in early pregnancy. Epidemiology 9:126–133PubMedCrossRefGoogle Scholar
  26. 26.
    Hogue P (1995) Characterization of exposures to extremely low frequency magnetic fields in the office environment. University of WashingtonGoogle Scholar
  27. 27.
    Hansen NH, Sobel E, Davanipour Z, Gillette LM, Niiranen J, Wilson BW (2000) EMF exposure assessment in the Finnish garment industry: evaluation of proposed EMF exposure metrics. Bioelectromagnetics 21:57–67PubMedCrossRefGoogle Scholar
  28. 28.
    Yost M (1999) Alternative magnetic field exposure metrics: occupational measurements in trolley workers. Radiat Prot Dosimetry 83:99–106Google Scholar
  29. 29.
    US Department of Commerce (1980) Standard occupational classification manual 1980. National Technical Information Service, SpringfieldGoogle Scholar
  30. 30.
    Rodvall Y, Ahlbom A, Stenlund C, Preston-Martin S, Lindh T, Spannare B (1998) Occupational exposure to magnetic fields and brain tumours in central Sweden. Eur J Epidemiol 14:563–569PubMedCrossRefGoogle Scholar
  31. 31.
    Schlehofer B, Kunze S, Sachsenheimer W, Blettner M, Niehoff D, Wahrendorf J (1990) Occupational risk factors for brain tumors: results from a population-based case–control study in Germany. Cancer Causes Control 1:209–215PubMedCrossRefGoogle Scholar
  32. 32.
    Benke G, Sim M, Fritschi L, Aldred G, Forbes A, Kauppinen T (2001) Comparison of occupational exposure using three different methods: hygiene panel, job exposure matrix (JEM), and self reports. Appl Occup Environ Hyg 16:84–91PubMedCrossRefGoogle Scholar
  33. 33.
    Navas-Acien A, Pollan M, Gustavsson P, Floderus B, Plato N, Dosemeci M (2002) Interactive effect of chemical substances and occupational electromagnetic field exposure on the risk of gliomas and meningiomas in Swedish men. Cancer Epidemiol Biomarkers Prev 11:1678–1683PubMedGoogle Scholar
  34. 34.
    Hurley SF, McNeil JJ, Donnan GA, Forbes A, Salzberg M, Giles GG (1996) Tobacco smoking and alcohol consumption as risk factors for glioma: a case–control study in Melbourne, Australia. J Epidemiol Commun Health 50:442–446CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media B.V. 2007

Authors and Affiliations

  • Ken Kyriakos Karipidis
    • 1
    • 2
  • Geza Benke
    • 1
  • Malcolm R. Sim
    • 1
  • Michael Yost
    • 3
  • Graham Giles
    • 4
  1. 1.Department of Epidemiology and Preventive MedicineMonash UniversityMelbourneAustralia
  2. 2.Non-Ionising Radiation BranchAustralian Radiation Protection and Nuclear Safety AgencyYallambieAustralia
  3. 3.Department of Environmental and Occupational Health SciencesUniversity of WashingtonSeattleUSA
  4. 4.Cancer Epidemiology CentreThe Cancer Council of VictoriaCarltonAustralia

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