Occupational exposure to low frequency magnetic fields and the risk of low grade and high grade glioma
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The purpose of this population-based case control study was to investigate a possible association between occupational exposure to low frequency magnetic fields and the risk of low grade glioma (LGG) and high grade glioma (HGG).
The study population consisted of 414 histologically confirmed cases of glioma (LGG = 110, HGG = 304), first diagnosed between July 1987 and December 1991, and 421 controls from Melbourne, Australia, matched by age, sex and postcode of residence. A detailed occupational history was obtained for each subject. Exposure to low frequency magnetic fields was estimated using three different methods: self-report, expert hygienist review and a job exposure matrix (JEM).
Elevated but statistically non-significant risk estimates were found for all glioma and HGG when exposure was assessed by the expert hygienist. The odds ratios (OR) for the highest exposed group of workers when assessed by the expert hygienist were 1.4 (95% confidence interval, CI: 0.85–2.27) and 1.51 (95% CI: 0.90–2.53) for all glioma and HGG, respectively. There were inverse associations for the self-reported and JEM exposures for both LGG and HGG but these may reflect limitations in these exposure assessment methods.
Our results do not support a role for occupational exposure to low frequency magnetic fields in the development of either LGG or HGG.
KeywordsLow grade glioma High grade glioma Case–control study Magnetic fields Occupational exposure
We thank all of the subjects who participated; the nurse interviewers, Ms J. Snaddon and Ms S. Gardiner; Ms L. Quango for computer programming assistance; and the participating neurosurgeons. This study was funded by grants from the National Health and Medical Research Council (NHMRC) of Australia, the Victorian Health Promotion Foundation and the Alfred Hospital.
- 3.Kleihues P, Cavenee WK (2000) Pathology and genetics of tumours of the nervous system. International Agency for Research on Cancer, LyonGoogle Scholar
- 13.International Commission on Non-Ionizing Radiation Protection (2003) Exposure to static and low frequency electromagnetic fields, biological effects and health consequences (0–100 kHz). ICNIRP, Oberschleibheim, pp 450–451Google Scholar
- 15.World Health Organization (1976) International classification of diseases for oncology (ICD-O). WHO, GenevaGoogle Scholar
- 17.International Labour Office (1969) International Standard classification of Occupations, 1968. ILO, GenevaGoogle Scholar
- 20.Electric Power Research Institute (1992) Electric and magnetic field exposure, chemical exposure, and leukemia risk in “electrical” occupations. Technical Report No. 101723. EPRI, Palo AltoGoogle Scholar
- 24.Touchstone J (1995) A comparison of EMF exposure assessment methods: on-site assessment versus a job exposure matrix. University of WashingtonGoogle Scholar
- 26.Hogue P (1995) Characterization of exposures to extremely low frequency magnetic fields in the office environment. University of WashingtonGoogle Scholar
- 28.Yost M (1999) Alternative magnetic field exposure metrics: occupational measurements in trolley workers. Radiat Prot Dosimetry 83:99–106Google Scholar
- 29.US Department of Commerce (1980) Standard occupational classification manual 1980. National Technical Information Service, SpringfieldGoogle Scholar