Prostatic fatty acids and cancer recurrence after radical prostatectomy for early-stage prostate cancer
- 161 Downloads
Results from some observational studies suggest that diet and energy balance influence the clinical course of early-stage prostate cancer. To evaluate possible mechanisms, we prospectively examined the relation between prostatic concentrations of fatty acids at diagnosis and cancer recurrence following primary therapy.
Fatty acids were measured by capillary gas chromatography in fresh, non-cancerous prostate tissue collected from 184 men undergoing radical prostatectomy for clinically localized prostate cancer. Their association with risk of biochemical disease recurrence (a rising serum prostate-specific antigen following a disease-free [<0.1 ng/ml] interval ≥6 months) was analyzed using Cox proportional hazards models incorporating patient age, body mass index, tumor characteristics at diagnosis, and ethnicity.
During an average follow-up of 48.7 months (median = 47), 14 patients experienced biochemical recurrence. Percent total polyunsaturated fatty acid and the ratio of oleic-to-stearic acid associated with risk (multivariable hazards ratio [HR] = 0.51, 95% confidence interval [CI] = 0.29 to 0.90, p = 0.021 and HR = 1.68, 95% CI = 1.21 to 2.33, p = 0.002, respectively, per 1 standard deviation increase).
The results of this study are preliminary, but they suggest that pre-diagnostic prostatic concentrations of fatty acids associate with risk of biochemical recurrence following radical prostatectomy for clinically localized prostate cancer.
KeywordsProstatic neoplasms Diet and nutrition Body mass index Biochemical recurrence Prognosis
- 2.Ries LAG, Eisner MP, Kosary CL et al (eds) SEER Cancer statistics review, 1975–2002, National Cancer Institute. Bethesda, MD http://seer.cancer.gov/csr/1975_2002/results_merged/sect_23_prostate.pdf, Table XXIIII-4. Based on November 2004 SEER data submission, posted to the SEER web site 2005. (Last accessed September 12, 2006)
- 3.National Comprehensive Cancer Network, Clinical Practice Guideline in Oncology: Prostate cancer. (v.2.2005, January 26, 2006). http://www.nccn.org/. (Last accessed September 12, 2006)
- 17.Hunter D (1998) Biochemical indicators of dietary intake. In: Willett W (ed) Nutritional Epidemiology, 2nd edn. Oxford University Press, New York, NY pp 174–243Google Scholar
- 18.Gleason DF (1977) Histologic grading of and staging of prostatic carcinoma. In: Tannenbaum M (ed) Urologic pathology: the prostate. Lea & Febiger, Philadelphia pp 171–197Google Scholar
- 19.Fleming ID, Cooper JS, Henson DE (1998) AJCC cancer staging manual, 5th edn. Lippincott-Raven, PhiladelphiaGoogle Scholar
- 20.Bova GS, Fox WM, Epstein IJ (1993) Methods of radical prostatectomy specimen processing: a novel technique for harvesting fresh prostate cancer tissue, review of processing techniques. Mol Pathol 6:201–207Google Scholar
- 23.Kalbfleisch JD, Prentice RL (1980) Statistical analysis of failure time data. Wiley, New York, NYGoogle Scholar
- 24.Therneau TM,Grambsch PM (2000) Modeling survival data. Extending the Cox Model. Springer, New York, NYGoogle Scholar
- 25.SAS [computer program] (2002–2003) Version 9.1. Cary, NC: SAS Institute, IncGoogle Scholar
- 30.Eastwood M (2003) Principles of human nutrition, 2nd edn. Blackwell Science Ltd, Oxford, UKGoogle Scholar