Cancer Causes & Control

, Volume 16, Issue 7, pp 857–864 | Cite as

Hair Dyes and Risk of Glioma Among Nebraska Women

  • Ellen F. Heineman
  • Mary H. Ward
  • Rodney D. McComb
  • Dennis D. Weisenburger
  • Shelia Hoar Zahm


The etiology of brain cancer is not well understood. We conducted a population-based case–control study among 112 white women in Nebraska who were newly diagnosed with glioma between July 1988 and June 1993, and 215 controls, to identify risk factors for this disease. A 1.7-fold increased risk of glioma was observed for women who ever used hair coloring products (95% confidence interval (CI) = 1.0–2.9, 62 cases), and a 2.4-fold risk for those who used permanent hair coloring products (odds ratio (OR) = 2.4, 95% CI  = 1.3–4.5, 39 cases). For women with the most aggressive form of glioma, glioblastoma multiforme, risk increased with duration of exposure to 4.9 (95% CI  = 1.6–15.7, 10 cases) after 21 or more years of permanent hair coloring use. Higher risks were observed with earlier age at first use, but we did not see an exposure-response pattern with frequency of use of permanent dyes. No association was observed with use of non-permanent (sometimes called temporary or semi-permanent) hair coloring products. These suggestive findings need confirmation in future studies with larger sample sizes, fewer proxy respondents, and the ability to evaluate the effect of changes in formulations over time.


brain cancer glioma hair dyes 


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  1. 1.
    Inskip, PD, Linet, MS, Heineman, EF 1995Etiology of brain tumors in adultsEpidemiol Rev17382414PubMedGoogle Scholar
  2. 2.
    Teta, MJ, Walrath, J, Meigs, JW, Flannery, JT 1984Cancer incidence among cosmetologistsJ Natl Cancer Inst7210511057PubMedGoogle Scholar
  3. 3.
    Neuberger, JS, Brownson, RC, Morantz, RA, Chin, TDY 1991Association of brain cancer with dental X-rays and occupation in MissouriCancer Detect Prev153134PubMedGoogle Scholar
  4. 4.
    International Agency for Research on Cancer (1993) IARC Monographs on the evaluation of the carcinogenic risk of chemicals to humans. Occupational exposures of hairdressers and barbers and personal use of hair colourants; some hair dyes, cosmetic colourants, cosmetic colourants, industrial dyestuffs, and aromatic amines, 57 Lyon: IARC.Google Scholar
  5. 5.
    Burch, JD, Craib, KJP, Choi, BCK, Miller, AB, Risch, HA, Howe, GR 1987An exploratory casecontrol study of brain tumors in adultsJ Natl Cancer Inst78601609PubMedGoogle Scholar
  6. 6.
    Zahm, SH, Weisenburger, DD, Babbitt, PA,  et al. 1990A case–control study of non-Hodgkin’s lymphoma and the herbicide 2,4-dichlorophenoxyacetic acid (2,4-D) in eastern NebraskaEpidemiology1349356PubMedGoogle Scholar
  7. 7.
    Kleihues, P, Burger, PC, Scheithauer, BW 1993The new WHO classification of brain tumoursBrain Pathol3255268PubMedGoogle Scholar
  8. 8.
    Chen, H, Ward, MH, Tucker, KL, Graubard, BI, McComb, RD, Potischman, NA, Weisenburger, DD, Heineman, EF 2002Diet and risk of adult glioma in eastern Nebraska, United StatesCancer Causes Control13647655CrossRefPubMedGoogle Scholar
  9. 9.
    Gart, JJ 1970Point and interval estimation of the common odds ratio in the combination of 2 × 2 tables with fixed marginalsBiometrika57471475Google Scholar
  10. 10.
    Kleinbaum, DK, Kupper, LL, Morgenstern, H 1982Epidemiologic researchLifetime Learning PublicationsBelmont, CAGoogle Scholar
  11. 11.
    Ahlbom, A, Navier, IL, Norell, S, Olin, R, Spannare, B 1986Nonoccupational risk indicators for astrocytoma in adultsAm J Epidemiol124334337PubMedGoogle Scholar
  12. 12.
    Thun, MJ, Altekruse, SF, Namboodiri, MM, Calle, EE, Myers, DG, Heath, CW,Jr 1994Hair dye use and risk of fatal cancers in U.S. womenJ Natl Cancer Inst86210215PubMedGoogle Scholar
  13. 13.
    Petersen GR, Milham Jr S (1980). Occupational mortality in the state of California 1959–61. DHEW Publication No. (NIOSH) 80–104. Cincinnati: National Institute for Occupational Safety and HealthGoogle Scholar
  14. 14.
    Milham Jr S (1983). Occupational mortality in Washington state 1950–79. DHHS Publication No. (NIOSH) 83–116. Cincinnati: National Institute for Occupational Safety and HealthGoogle Scholar
  15. 15.
    Gallagher, RP, Threlfall, WJ, Band, PR, Spinelli, JJ 1989Occupational mortality in British Columbia 1950–1984Cancer Control Agency of British Columbia and Workers’ Compensation Board of British ColumbiaVancouverGoogle Scholar
  16. 16.
    Pukkala, E, Nokso-Koivisto, P, Roponen, P 1992Changing cancer risk pattern among Finnish hairdressersInt Arch Occup Environ Health643942CrossRefPubMedGoogle Scholar
  17. 17.
    Hrubec Z, Blair AE, Rogot E, Vaught J (1992). Mortality risks by occupation among U.S. veterans of known smoking status 1954–1980. Vol 1. NIH Publication No. 92–3407. Bethesda: National Institutes of HealthGoogle Scholar
  18. 18.
    Lamba, AB, Ward, MH, Weeks, JL, Dosemeci, M 2001Cancer mortality patterns among hairdressers and barbers in 24 US states, 1984 to 1995J Occup Environ Med43250258PubMedGoogle Scholar
  19. 19.
    Kuijten, RR, Bunin, GR, Nass, CC, Meadows, AT 1992Parental occupation and childhood astrocytoma: results of a casecontrol studyCancer Res52782786PubMedGoogle Scholar
  20. 20.
    Bunin, GR, Buckley, JD, Boesel, CP, Rorke, LB, Meadows, AT 1994Risk factors for astrocytic glioma and primitive neuroectodermal tumor of the brain in young children: a report from the Children’s Cancer GroupCancer Epidemiol Biomarkers Prev3197204PubMedGoogle Scholar
  21. 21.
    Holly, EA, Bracci, PM, Hong, MK, Mueller, BA, Preston-Martin, S 2002West Coast study of childhood brain tumours and maternal use of hair-colouring productsPaediatric Perinatal Epidemiol16226235CrossRefGoogle Scholar
  22. 22.
    Corbett, JF 1999An historical review of the use of dye precursors in the formulation of commercial oxidation hair dyesDyes Pigments41127136CrossRefGoogle Scholar
  23. 23.
    Zhang, Y, Holford, TR, Leaderer, B 2004Hair-coloring product use and risk of non-Hodgkin’s lymphoma: A population-based case–control study in ConnecticutAm J Epidemiol159148154CrossRefPubMedGoogle Scholar
  24. 24.
    Furnari, FB, Huang, HJ, Cavenee, WK 1995Genetics and malignant progression of human brain tumoursCancer Surv25233275PubMedGoogle Scholar

Copyright information

© Springer 2005

Authors and Affiliations

  • Ellen F. Heineman
    • 1
  • Mary H. Ward
    • 1
  • Rodney D. McComb
    • 2
  • Dennis D. Weisenburger
    • 2
  • Shelia Hoar Zahm
    • 1
  1. 1.Division of Cancer Epidemiology and Genetics, NIH, DHHSNational Cancer InstituteBethesdaUSA
  2. 2.Department of Pathology and MicrobiologyUniversity of Nebraska Medical CenterOmahaUSA

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