Cancer Causes & Control

, Volume 16, Issue 5, pp 537–544 | Cite as

Previous oral contraceptive use and breast cancer risk according to hormone replacement therapy use among postmenopausal women

  • Vanessa Dumeaux
  • Agnès Fournier
  • Eiliv Lund
  • Françoise Clavel-Chapelon



To assess postmenopausal breast cancer risk in relation to particular patterns of oral contraceptive (OC) use according to hormone replacement therapy (HRT) exposure.


Time-dependent Cox regression models were used to analyse information on postmenopausal women from a large-scale French cohort. Among a total of 68,670 women born between 1925 and 1950, 1405 primary invasive postmenopausal breast cancer cases were identified from 1992 to 2000.


A non-significant decrease in risk of around 10% was associated with ever OC use as compared to never OC use in postmenopausal women. No significant interaction was found between OC and HRT use on postmenopausal breast cancer risk. Breast cancer risk decreased significantly with increasing time since first OC use (test for trend: p=0.01); this was consistent after adjustment for duration of use or for time since last use.


No increase in breast cancer risk was associated with previous OC exposure among postmenopausal women, probably because the induction window had closed. Some women may develop breast cancer soon after exposure to OCs, leading to a deficit of cases of older women. Further investigation is therefore required to identify young women at high risk.


breast cancer postmenopausal women oral contraceptives patterns of use hormone replacement therapy. 


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Copyright information

© Springer 2005

Authors and Affiliations

  • Vanessa Dumeaux
    • 1
    • 2
  • Agnès Fournier
    • 2
  • Eiliv Lund
    • 1
  • Françoise Clavel-Chapelon
    • 2
  1. 1.Institute of Community MedicineUniversity of TromsøFrance
  2. 2.Institut Gustave-RoussyINSERM “Nutrition, Hormones, Cancer”, Equipe E3N-EPICVillejuifFrance

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