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Chest wall recurrence in pT1-2N0-1 breast cancer patients after mastectomy without radiotherapy

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Abstract

Purpose

In correlation with the nodal status in the era of modern radiotherapy, the chest wall recurrence (CWR) rate was investigated in pT1-2N0-1 breast cancer patients after a mastectomy without post-mastectomy radiotherapy (PMRT).

Methods

The data from the patients participating in two South Korean multi-institutional studies (KROG 14–22; N = 1842 and KROG 14–23; N = 1382) were analyzed. In total, 3224 pT1-2N0-1 breast cancer patients who underwent mastectomy without PMRT were analyzed.

Results

The median follow-up time was 72.2 months (range 0.8–125.2 months). The overall CWRs during the follow-up period were 1.68% in N0 patients and 2.82% in N1 patients. There was no statistically significant difference in 5-year and 10-year CWR-free survival (CWRFS) between the N0 and N1 patients. Of the 70 patients with CWR, 33 (1% of all the patients) had isolated CWR, and the 10-year overall survival rate in this group was 96.9%. After the propensity score matching of the N0 and N1 groups, there was still no difference in CWRFS by nodal status.

Conclusions

The incidence of CWR in pT1-2N0-1 breast cancer patients is very low, especially with isolated recurrence. Also, the obtained data showed that the nodal status had no impact on CWRFS.

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Author information

Authors and Affiliations

  1. Department of Radiation Oncology, Seoul Metropolitan Government Seoul National University Boramae Medical Center, Seoul, Korea

    Ji Hyun Chang & Suzy Kim

  2. Department of Radiation Oncology, Seoul National University College of Medicine, 101, Daehak-ro, Jongno-gu, Seoul, 03080, Korea

    Kyung Hwan Shin, Eui Kyu Chie & Jin Ho Kim

  3. Department of Radiation Oncology, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-gu, Seoul, 138-736, Korea

    Seung Do Ahn & Su Ssan Kim

  4. Department of Radiation Oncology, Hanyang University Hospital, Seoul, Korea

    Hae Jin Park

  5. Department of Radiation Oncology, Yonsei University College of Medicine, Seoul, Korea

    Yong Bae Kim

  6. Department of Radiation Oncology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea

    Won Park

  7. Department of Radiation Oncology, Proton Therapy Center, National Cancer Center, Goyang, Korea

    Yeon-Joo Kim

  8. Department of Radiation Oncology, CHA University School of Medicine, Pocheon, Korea

    Hyun Soo Shin

  9. Department of Radiation Oncology, Keimyung University School of Medicine, Daegu, Korea

    Jin Hee Kim

  10. Department of Radiation Oncology, Chonbuk National University Hospital, Jeonju, Korea

    Sun Young Lee

  11. Department of Radiation Oncology, Ewha Womans University School of Medicine, Seoul, Korea

    Kyubo Kim

  12. Department of Radiation Oncology, Ewha Womans University Mokdong Hospital, Seoul, Korea

    Kyung Ran Park

  13. Department of Radiation Oncology, Gyeongsang National University School of Medicine, Jinju, Korea

    Bae Kwon Jeong

  14. Department of Radiation Oncology, Asan Medical Center, Seoul, Korea

    Ja Young Kim

Authors
  1. Ji Hyun Chang
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  2. Kyung Hwan Shin
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  6. Jin Ho Kim
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  7. Su Ssan Kim
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  9. Won Park
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  11. Hyun Soo Shin
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  12. Jin Hee Kim
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  13. Sun Young Lee
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  14. Kyubo Kim
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  15. Kyung Ran Park
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  16. Bae Kwon Jeong
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  17. Ja Young Kim
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  18. Suzy Kim
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Corresponding authors

Correspondence to Kyung Hwan Shin or Seung Do Ahn.

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Chang, J.H., Shin, K.H., Ahn, S.D. et al. Chest wall recurrence in pT1-2N0-1 breast cancer patients after mastectomy without radiotherapy. Breast Cancer Res Treat 169, 507–512 (2018). https://doi.org/10.1007/s10549-018-4707-0

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  • DOI: https://doi.org/10.1007/s10549-018-4707-0

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