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Breast Cancer Research and Treatment

, Volume 169, Issue 3, pp 595–606 | Cite as

Differences in breast cancer incidence among young women aged 20–49 years by stage and tumor characteristics, age, race, and ethnicity, 2004–2013

  • Meredith L. Shoemaker
  • Mary C. White
  • Manxia Wu
  • Hannah K. Weir
  • Isabelle Romieu
Epidemiology

Abstract

Purpose

Younger women diagnosed with breast cancer have poorer prognoses and higher mortality compared to older women. Young black women have higher incidence rates of breast cancer and more aggressive subtypes than women of other races/ethnicities. In this study, we examined recent trends and variations in breast cancer incidence among young women in the United States.

Methods

Using 2004–2013 National Program of Cancer Registries and Surveillance, Epidemiology, and End Results Program data, we calculated breast cancer incidence rates and trends and examined variations in stage, grade, and tumor subtype by age and race/ethnicity among young women aged 20–49 years.

Results

The majority of breast cancer cases occurred in women aged 40–44 and 45–49 years (77.3%). Among women aged < 45 years, breast cancer incidence was highest among black women. Incidence trends increased from 2004 to 2013 for Asian or Pacific Islander (API) women and white women aged 20–34 years. Black, American Indian or Alaska Native, and Hispanic women had higher proportions of cases diagnosed at later stages than white and API women. Black women had a higher proportion of grade III–IV tumors than other racial/ethnic groups. Across all age groups, incidence rates for triple-negative breast cancer were significantly higher in black women than women of other races/ethnicities, and this disparity increased with age.

Conclusions

Breast cancer among young women is a highly heterogeneous disease. Differences in tumor characteristics by age and race/ethnicity suggest opportunities for further research into personal and cultural factors that may influence breast cancer risk among younger women.

Keywords

Breast cancer Young women Health disparities Tumor subtype Triple-negative breast cancer Cancer registries 

Abbreviation

AIAN

American Indian or Alaska Native

APC

Annual percent change

API

Asian or Pacific Islander

CI

Confidence interval

ER

Estrogen receptor

HER2

Human growth factor/neu receptor

HR

Hormone receptor

ICD-O-3

International Classification of Diseases for Oncology third edition

NH

Non-Hispanic

NPCR

National Program of Cancer Registries

PR

Progesterone receptor

SEER

Surveillance, epidemiology, and end results program

TN

Triple-negative

USCS

United States Cancer Statistics

Notes

Acknowledgements

This research was supported in part by an appointment (M.L. Shoemaker) to the Research Participation Program at the Centers for Disease Control and Prevention administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the US Department of Energy and CDC.

Disclaimer

The findings and conclusions in this report are those of the authors and do not necessarily represent the official position of the Centers for Disease Control and Prevention.

Compliance with ethical standards

Conflicts of interest

The authors declare that they have no conflict of interests.

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Copyright information

© This is a U.S. government work and its text is not subject to copyright protection in the United States; however, its text may be subject to foreign copyright protection 2018

Authors and Affiliations

  1. 1.Epidemiology and Applied Research Branch, Division of Cancer Prevention and Control, National Center for Chronic Disease Prevention and Health PromotionCenters for Disease Control and PreventionAtlantaUSA
  2. 2.Nutrition and Metabolism SectionInternational Agency for Research on CancerLyonFrance
  3. 3.Center for Research on Population HealthNational Institute of Public HealthCuernavacaMexico
  4. 4.Hubert Department of Global HealthEmory UniversityAtlantaUSA

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