Dose adjustment in obese breast cancer patients receiving neoadjuvant chemotherapy might have an impact on survival
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To the Editor,
I wish to congratulate Liu and colleagues for their article  in which they tried to find out an association between obesity and survival in the neoadjuvant breast cancer receiving adriamycin/taxane-based chemotherapy. They reported that obesity may negatively impact survival, with differences among tumor subtypes. However, the authors did not report about the adjustment of the chemotherapy dose to the patients’ exact body surface area (BSA) values. Karatas et al. recently reported that obesity had an adverse effect on pathological complete response (pCR) among women with neoadjuvant chemotherapy (NAC) . However, study by Karatas et al. did not uniformly adjust the dose to the patients’ exact BSA values, limiting them at a lower level of 2 m2 to prevent side effects. Contrary to Karatas et al. study, Farr et al. found that obese women receiving full uncapped doses of anthracycline-taxane-based NAC have increased pCR and favorable progression-free survival. They concluded that this could result from increased dose intensity with increased efficacy and toxicity . Taken all together, dose adjustment in obese breast cancer patients receiving NAC might have an impact on survival.
Compliance with ethical standards
Conflict of interest
I have no conflict of interest to declare.
My manuscript complies with the Ethical Rules applicable for this journal. This article does not contain any studies with human participants or animals performed by any of the authors.
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