Adolescent intake of animal fat and red meat in relation to premenopausal mammographic density
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Adolescence is hypothesized to be a time period of particular susceptibility to breast cancer risk factors. Red meat and fat intake during high school was positively associated with risk of breast cancer among premenopausal women in the Nurses’ Health Study II (NHSII). High mammographic density is a strong predictor of breast cancer risk but there is limited research on dietary factors associated with breast density. To test the hypothesis that high intake of animal fat or red meat during adolescence is associated with mammographic density, we analyzed data from premenopausal women in the NHSII. Participants recalled adolescent diet on a high school food frequency questionnaire. We assessed absolute and percent mammographic density on digitized analog film mammograms for 687 premenopausal women with no history of cancer. We used generalized linear regression to quantify associations of adolescent animal fat and red meat intake with mammographic density, adjusting for age, body mass index, and other predictors of mammographic density. Adolescent animal fat intake was significantly positively associated with premenopausal mammographic density, with a mean percent density of 39.2 % in the lowest quartile of adolescent animal fat intake versus 43.1 % in the highest quartile (p trend: 0.03). A non-significant positive association was also observed for adolescent red meat intake (p trend: 0.14). These findings suggest that higher adolescent animal fat intake is weakly associated with percent mammographic density in premenopausal women.
KeywordsAdolescence Animal fat Red meat Premenopausal Mammographic density Breast cancer Epidemiology
We thank Barbara DeSouza, Divya Prithviraj, and Ellen Hertzmark for their assistance with data collection and analysis. This work was supported by the Breast Cancer Research Foundation and the National Cancer Institute (UM1 CA176726, R01 CA124865, R01 CA67262, and R01 CA50385). KAB was supported by the Simeon J. Fortin Charitable Foundation Fellowship, Bank of America, N.A., Co-Trustee.
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Conflict of interest
The authors declare that they have no conflict of interest.
- 1.Biro FM, Deardorff J (2013) Identifying opportunities for cancer prevention during preadolescence and adolescence: puberty as a window of susceptibility. J Adolesc Health 52(5 Suppl):019Google Scholar
- 2.Colditz GA, Frazier AL (1995) Models of breast cancer show that risk is set by events of early life: prevention efforts must shift focus. Cancer Epidemiol Biomark Prev 4(5):567–571Google Scholar
- 4.Mahabir S (2012) Association between diet during preadolescence and adolescence and risk for Breast Cancer During Adulthood. J Adolesc Health 8(12):00352–00357Google Scholar
- 14.Sellers TA, Vachon CM, Pankratz VS, Janney CA, Fredericksen Z, Brandt KR, Huang Y, Couch FJ, Kushi LH, Cerhan JR (2007) Association of childhood and adolescent anthropometric factors, physical activity, and diet with adult mammographic breast density. Am J Epidemiol 166(4):456–464CrossRefPubMedGoogle Scholar
- 16.Dorgan JF, Liu L, Klifa C, Hylton N, Shepherd JA, Stanczyk FZ, Snetselaar LG, Van Horn L, Stevens VJ, Robson A et al (2010) Adolescent diet and subsequent serum hormones, breast density, and bone mineral density in young women: results of the Dietary Intervention Study in Children follow-up study. Cancer Epidemiol Biomark Prev 19(6):1545–1556CrossRefGoogle Scholar
- 24.U.S. Department of Agriculture, Agricultural Research Service (2001) USDA National Nutrient Database for Standard Reference, Release 14. Nutrient Data Laboratory Home Page. http://www.ars.usda.gov/nea/bhnrc/ndl
- 32.Boyd NF, Lockwood GA, Greenberg CV, Martin LJ, Tritchler DL (1997) Effects of a low-fat high-carbohydrate diet on plasma sex hormones in premenopausal women: results from a randomized controlled trial. Canadian Diet and Breast Cancer Prevention Study Group. Br J Cancer 76(1):127–135PubMedCentralCrossRefPubMedGoogle Scholar
- 33.Crowe FL, Key TJ, Allen NE, Appleby PN, Roddam A, Overvad K, Gronbaek H, Tjonneland A, Halkjaer J, Dossus L et al (2009) The association between diet and serum concentrations of IGF-I, IGFBP-1, IGFBP-2, and IGFBP-3 in the European prospective investigation into cancer and nutrition. Cancer Epidemiol Biomark Prev 18(5):1333–1340CrossRefGoogle Scholar
- 34.Holmes MD, Pollak MN, Willett WC, Hankinson SE (2002) Dietary correlates of plasma insulin-like growth factor I and insulin-like growth factor binding protein 3 concentrations. Cancer Epidemiol Biomark Prev 11(9):852–861Google Scholar
- 36.Vrieling A, Voskuil DW, Bueno de Mesquita HB, Kaaks R, van Noord PA, Keinan-Boker L, van Gils CH, Peeters PH (2004) Dietary determinants of circulating insulin-like growth factor (IGF)-I and IGF binding proteins 1, -2 and -3 in women in the Netherlands. Cancer Causes Control 15(8):787–796CrossRefPubMedGoogle Scholar