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Breast Cancer Research and Treatment

, Volume 151, Issue 3, pp 687–696 | Cite as

Racial and ethnic differences in risk of second primary cancers among breast cancer survivors

  • Gregory S. Calip
  • Ernest H. Law
  • Naomi Y. Ko
Epidemiology

Abstract

Disparities exist in breast cancer (BC) outcomes between racial and ethnic groups in the United States. Reasons for these disparities are multifactorial including differences in genetics, stage at presentation, access to care, and socioeconomic factors. Less is documented on racial/ethnic differences in subsequent risk of second primary cancers (SPC). The purpose of this study is to evaluate the risk of SPC among different racial/ethnic groups of women with BC. We conducted a retrospective cohort study of 134,868 Non-Hispanic White, 17,484 Black, 18,034 Hispanic, and 19,802 Asian/Pacific Islander (API) women with stages I–III BC in twelve Surveillance, Epidemiology and End Results Program registries between 2001 and 2010. Standardized incidence ratios (SIR), 95 % confidence intervals (CI), and absolute excess risks were calculated by comparing incidence of SPC in the cohort to incidence in the general population for specific cancer sites by race/ethnicity and stratified by index BC characteristics. All women were at increased risks of second primary BC and acute myeloid leukemia (AML), with higher risk among more advanced stage index BC. Black and API women had higher SIRs for AML [4.86 (95 % CI 3.05–7.36) and 5.00 (95 % CI 3.26–7.32)], respectively] which remained elevated among early-stage (I) BC cases. Women with a history of invasive BC have increased risk of SPC, most notable for second primary BC and AML. These risks for secondary cancers differ by race/ethnicity. Studies evaluating possible genetic and biobehavioral mechanisms underlying these differences are warranted. Strategies for BC adjuvant treatment and survivorship care may require further individualization with consideration given to race/ethnicity.

Keywords

Breast cancer Second primary cancer Racial/ethnic disparities Survivorship Surveillance 

Notes

Acknowledgments

The authors would like to express their gratitude to Dr. Eric P. Winer for his guidance and comments on revisions of this manuscript.

Conflict of interest

The authors declare that they have no conflict of interest.

Funding

This work was supported by the National Institutes of Health (R25 CA094880) Cancer Prevention Training Grant in Nutrition, Exercise and Genetics at the University of Washington and the Carter Disparities Fund at Boston Medical Center. E.H.L. was supported by the 2014–2016 UIC/Takeda Fellowship in Health Economics and Outcomes Research.

Supplementary material

10549_2015_3439_MOESM1_ESM.doc (99 kb)
Supplementary material 1 (DOC 99 kb)

References

  1. 1.
    Siegel R, Ma J, Zou Z, Jemal A (2014) Cancer statistics, 2014. CA Cancer J Clin 64(1):9–29. doi: 10.3322/caac.21208 CrossRefPubMedGoogle Scholar
  2. 2.
    American Cancer Society (2014) Cancer treatment and survivorship facts & figures 2014–2015. American Cancer Society Inc, AtlantaGoogle Scholar
  3. 3.
    Gotzsche PC, Nielsen M (2006) Screening for breast cancer with mammography. Cochrane Database Syst Rev. doi: 10.1002/14651858.CD001877.pub2 Google Scholar
  4. 4.
    American Cancer Society (2013) Breast cancer facts & figures 2013–2014. American Cancer Society Inc, AtlantaGoogle Scholar
  5. 5.
    Hayat MJ, Howlader N, Reichman ME, Edwards BK (2007) Cancer statistics, trends, and multiple primary cancer analyses from the surveillance, epidemiology, and end results (SEER) program. Oncologist 12(1):20–37. doi: 10.1634/theoncologist.12-1-20 CrossRefPubMedGoogle Scholar
  6. 6.
    Ooi SL, Martinez ME, Li CI (2011) Disparities in breast cancer characteristics and outcomes by race/ethnicity. Breast Cancer Res Treat 127(3):729–738. doi: 10.1007/s10549-010-1191-6 CrossRefPubMedCentralPubMedGoogle Scholar
  7. 7.
    Li CI, Malone KE, Daling JR (2003) Differences in breast cancer stage, treatment, and survival by race and ethnicity. Arch Intern Med 163(1):49–56CrossRefPubMedGoogle Scholar
  8. 8.
    Baquet CR, Commiskey P (2000) Socioeconomic factors and breast carcinoma in multicultural women. Cancer 88(5 Suppl):1256–1264CrossRefPubMedGoogle Scholar
  9. 9.
    Curtis E, Quale C, Haggstrom D, Smith-Bindman R (2008) Racial and ethnic differences in breast cancer survival: how much is explained by screening, tumor severity, biology, treatment, comorbidities, and demographics? Cancer 112(1):171–180. doi: 10.1002/cncr.23131 CrossRefPubMedCentralPubMedGoogle Scholar
  10. 10.
    Khatcheressian JL, Hurley P, Bantug E, Esserman LJ, Grunfeld E, Halberg F, Hantel A, Henry NL, Muss HB, Smith TJ, Vogel VG, Wolff AC, Somerfield MR, Davidson NE, American Society of Clinical O (2013) Breast cancer follow-up and management after primary treatment: American Society of Clinical Oncology clinical practice guideline update. J Clin Oncol 31(7):961–965. doi: 10.1200/JCO.2012.45.9859 CrossRefPubMedGoogle Scholar
  11. 11.
    Hunter CP (2000) Epidemiology, stage at diagnosis, and tumor biology of breast carcinoma in multiracial and multiethnic populations. Cancer 88(5 Suppl):1193–1202CrossRefPubMedGoogle Scholar
  12. 12.
    Ko NY, Darnell JS, Calhoun E, Freund KM, Wells KJ, Shapiro CL, Dudley DJ, Patierno SR, Fiscella K, Raich P, Battaglia TA (2014) Can patient navigation improve receipt of recommended breast cancer care? Evidence from the national patient navigation research program. J Clin Oncol 32(25):2758–2764. doi: 10.1200/JCO.2013.53.6037 CrossRefPubMedGoogle Scholar
  13. 13.
    Surveillance, Epidemiology, and End Results (SEER) Program (www.seer.cancer.gov) SEER*Stat Database: Populations—Total U.S. (1969–2012) <Single Ages to 85+, Katrina/Rita Adjustment>—Linked To County Attributes—Total U.S., 1969–2012 Counties, National Cancer Institute, DCCPS, Surveillance Research Program, Surveillance Systems Branch, released April 2014. Accessed September 2014
  14. 14.
    Singletary SE, Allred C, Ashley P, Bassett LW, Berry D, Bland KI, Borgen PI, Clark GM, Edge SB, Hayes DF, Hughes LL, Hutter RV, Morrow M, Page DL, Recht A, Theriault RL, Thor A, Weaver DL, Wieand HS, Greene FL (2003) Staging system for breast cancer: revisions for the 6th edition of the AJCC Cancer Staging Manual. Surg Clin N Am 83(4):803–819. doi: 10.1016/S0039-6109(03)00034-3 CrossRefPubMedGoogle Scholar
  15. 15.
    Surveillance Research Program, National Cancer Institute SEER*Stat software (seer.cancer.gov/seerstat) version < 8.1.5>Google Scholar
  16. 16.
    Balduzzi A, Castiglione-Gertsch M (2005) Leukemia risk after adjuvant treatment of early breast cancerGoogle Scholar
  17. 17.
    Chaudary MA, Millis RR, Hoskins EO, Halder M, Bulbrook RD, Cuzick J, Hayward JL (1984) Bilateral primary breast cancer: a prospective study of disease incidence. Br J Surg 71(9):711–714CrossRefPubMedGoogle Scholar
  18. 18.
    Le Deley M-C, Suzan F, Cutuli B, Delaloge S, Shamsaldin A, Linassier C, Clisant S, de Vathaire F, Fenaux P, Hill C (2007) Anthracyclines, mitoxantrone, radiotherapy, and granulocyte colony-stimulating factor: risk factors for leukemia and myelodysplastic syndrome after breast cancer. J Clin Oncol 25(3):292–300CrossRefPubMedGoogle Scholar
  19. 19.
    Mellemkjær L, Friis S, Olsen JH, Scélo G, Hemminki K, Tracey E, Andersen A, Brewster DH, Pukkala E, McBride ML (2006) Risk of second cancer among women with breast cancer. Int J Cancer 118(9):2285–2292CrossRefPubMedGoogle Scholar
  20. 20.
    Soerjomataram I, Louwman WJ, de Vries E, Lemmens VE, Klokman WJ, Coebergh JW (2005) Primary malignancy after primary female breast cancer in the South of the Netherlands, 1972–2001. Breast Cancer Res Treat 93(1):91–95. doi: 10.1007/s10549-005-4016-2 CrossRefPubMedGoogle Scholar
  21. 21.
    Chaplain G, Milan C, Sgro C, Carli P-M, Bonithon-Kopp C (2000) Increased risk of acute leukemia after adjuvant chemotherapy for breast cancer: a population-based study. J Clin Oncol 18(15):2836–2842PubMedGoogle Scholar
  22. 22.
    Morton LM, Dores GM, Tucker MA, Kim CJ, Onel K, Gilbert ES, Fraumeni JF, Curtis RE (2013) Evolving risk of therapy-related acute myeloid leukemia following cancer chemotherapy among adults in the United States, 1975–2008. Blood 121(15):2996–3004CrossRefPubMedCentralPubMedGoogle Scholar
  23. 23.
    Smith RE, Bryant J, DeCillis A, Anderson S (2003) Acute myeloid leukemia and myelodysplastic syndrome after doxorubicin-cyclophosphamide adjuvant therapy for operable breast cancer: the National Surgical Adjuvant Breast and Bowel Project Experience. J Clin Oncol 21(7):1195–1204CrossRefPubMedGoogle Scholar
  24. 24.
    Kaplan H, Malmgren J, De Roos AJ (2013) Risk of myelodysplastic syndrome and acute myeloid leukemia post radiation treatment for breast cancer: a population-based study. Breast Cancer Res Treat 137(3):863–867. doi: 10.1007/s10549-012-2386-9 CrossRefPubMedGoogle Scholar
  25. 25.
    Kaplan HG, Malmgren JA, Li CI, Calip GS (2013) Age related risk of myelodysplastic syndrome and acute myeloid leukemia among breast cancer survivors. Breast Cancer Res Treat 142(3):629–636. doi: 10.1007/s10549-013-2773-x CrossRefPubMedGoogle Scholar
  26. 26.
    Martin MG, Welch JS, Luo J, Ellis MJ, Graubert TA, Walter MJ (2009) Therapy related acute myeloid leukemia in breast cancer survivors, a population-based study. Breast Cancer Res Treat 118(3):593–598. doi: 10.1007/s10549-009-0376-3 CrossRefPubMedCentralPubMedGoogle Scholar
  27. 27.
    Czader M, Orazi A (2009) Therapy-related myeloid neoplasms. Am J Clin Pathol 132(3):410–425. doi: 10.1309/AJCPD85MCOHHCOMQ CrossRefPubMedGoogle Scholar
  28. 28.
    Azim HA Jr, de Azambuja E, Colozza M, Bines J, Piccart MJ (2011) Long-term toxic effects of adjuvant chemotherapy in breast cancer. Ann Oncol 22(9):1939–1947. doi: 10.1093/annonc/mdq683 CrossRefPubMedGoogle Scholar
  29. 29.
    Patel M, Ma Y, Mitchell B, Rhoads K (2012) Understanding disparities in leukemia: a national study. Cancer Causes Control 23(11):1831–1837CrossRefPubMedGoogle Scholar
  30. 30.
    Pulte D, Redaniel MT, Jansen L, Brenner H, Jeffreys M (2013) Recent trends in survival of adult patients with acute leukemia: overall improvements, but persistent and partly increasing disparity in survival of patients from minority groups. Haematologica 98(2):222–229CrossRefPubMedCentralPubMedGoogle Scholar
  31. 31.
    Sekeres MA, Peterson B, Dodge RK, Mayer RJ, Moore JO, Lee EJ, Kolitz J, Baer MR, Schiffer CA, Carroll AJ (2004) Differences in prognostic factors and outcomes in African Americans and whites with acute myeloid leukemia. Blood 103(11):4036–4042CrossRefPubMedGoogle Scholar
  32. 32.
    Hershman D, Neugut AI, Jacobson JS, Wang J, Tsai W-Y, McBride R, Bennett CL, Grann VR (2007) Acute myeloid leukemia or myelodysplastic syndrome following use of granulocyte colony-stimulating factors during breast cancer adjuvant chemotherapy. J Natl Cancer Inst 99(3):196–205CrossRefPubMedGoogle Scholar
  33. 33.
    Innos K, Horn-Ross PL (2008) Risk of second primary breast cancers among women with ductal carcinoma in situ of the breast. Breast Cancer Res Treat 111(3):531–540. doi: 10.1007/s10549-007-9807-1 CrossRefPubMedGoogle Scholar
  34. 34.
    Li CI, Malone KE, Saltzman BS, Daling JR (2006) Risk of invasive breast carcinoma among women diagnosed with ductal carcinoma in situ and lobular carcinoma in situ, 1988–2001. Cancer 106(10):2104–2112. doi: 10.1002/cncr.21864 CrossRefPubMedGoogle Scholar
  35. 35.
    Liu Y, Colditz GA, Gehlert S, Goodman M (2014) Racial disparities in risk of second breast tumors after ductal carcinoma in situ. Breast Cancer Res Treat 148(1):163–173. doi: 10.1007/s10549-014-3151-z CrossRefPubMedCentralPubMedGoogle Scholar
  36. 36.
    Stark A, Stapp R, Raghunathan A, Yan X, Kirchner HL, Griggs J, Newman L, Chitale D, Dick A (2012) Disease-free probability after the first primary ductal carcinoma in situ of the breast: a comparison between African-American and White-American women. Breast Cancer Res Treat 131(2):561–570. doi: 10.1007/s10549-011-1742-5 CrossRefPubMedCentralPubMedGoogle Scholar
  37. 37.
    Ademuyiwa FO, Olopade OI (2003) Racial differences in genetic factors associated with breast cancer. Cancer Metastasis Rev 22(1):47–53CrossRefPubMedGoogle Scholar
  38. 38.
    Cross CK, Harris J, Recht A (2002) Race, socioeconomic status, and breast carcinoma in the U.S: what have we learned from clinical studies. Cancer 95(9):1988–1999. doi: 10.1002/cncr.10830 CrossRefPubMedGoogle Scholar
  39. 39.
    Dayal HH, Power RN, Chiu C (1982) Race and socio-economic status in survival from breast cancer. J Chronic Dis 35(8):675–683CrossRefPubMedGoogle Scholar
  40. 40.
    Yood MU, Johnson CC, Blount A, Abrams J, Wolman E, McCarthy BD, Raju U, Nathanson DS, Worsham M, Wolman SR (1999) Race and differences in breast cancer survival in a managed care population. J Natl Cancer Inst 91(17):1487–1491CrossRefPubMedGoogle Scholar
  41. 41.
    Perkins P, Cooksley CD, Cox JD (1996) Breast cancer. Is ethnicity an independent prognostic factor for survival? Cancer 78(6):1241–1247. doi: 10.1002/(SICI)1097-0142(19960915)78:6<1241:AID-CNCR11>3.0.CO;2-0 CrossRefPubMedGoogle Scholar
  42. 42.
    Bradley CJ, Given CW, Roberts C (2002) Race, socioeconomic status, and breast cancer treatment and survival. J Natl Cancer Inst 94(7):490–496CrossRefPubMedGoogle Scholar
  43. 43.
    Ansell D, Whitman S, Lipton R, Cooper R (1993) Race, income, and survival from breast cancer at two public hospitals. Cancer 72(10):2974–2978CrossRefPubMedGoogle Scholar
  44. 44.
    Roetzheim RG, Pal N, Tennant C, Voti L, Ayanian JZ, Schwabe A, Krischer JP (1999) Effects of health insurance and race on early detection of cancer. J Natl Cancer Inst 91(16):1409–1415CrossRefPubMedGoogle Scholar
  45. 45.
    Lannin DR, Mathews HF, Mitchell J, Swanson MS, Swanson FH, Edwards MS (1998) Influence of socioeconomic and cultural factors on racial differences in late-stage presentation of breast cancer. JAMA 279(22):1801–1807CrossRefPubMedGoogle Scholar
  46. 46.
    Jones BA, Kasi SV, Curnen MG, Owens PH, Dubrow R (1997) Severe obesity as an explanatory factor for the black/white difference in stage at diagnosis of breast cancer. Am J Epidemiol 146(5):394–404CrossRefPubMedGoogle Scholar
  47. 47.
    McCarthy EP, Burns RB, Coughlin SS, Freund KM, Rice J, Marwill SL, Ash A, Shwartz M, Moskowitz MA (1998) Mammography use helps to explain differences in breast cancer stage at diagnosis between older black and white women. Ann Intern Med 128(9):729–736CrossRefPubMedGoogle Scholar
  48. 48.
    Martires KJ, Kurlander DE, Minwell GJ, Dahms EB, Bordeaux JS (2014) Patterns of cancer screening in primary care from 2005 to 2010. Cancer 120(2):253–261. doi: 10.1002/cncr.28403 CrossRefPubMedGoogle Scholar
  49. 49.
    Wirtz HS, Boudreau DM, Gralow JR, Barlow WE, Gray S, Bowles EJ, Buist DS (2014) Factors associated with long-term adherence to annual surveillance mammography among breast cancer survivors. Breast Cancer Res Treat 143(3):541–550. doi: 10.1007/s10549-013-2816-3 CrossRefPubMedCentralPubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  1. 1.Center for Pharmacoepidemiology and Pharmacoeconomic ResearchUniversity of Illinois at ChicagoChicagoUSA
  2. 2.Division of Public Health SciencesFred Hutchinson Cancer Research CenterSeattleUSA
  3. 3.Department of EpidemiologyUniversity of WashingtonSeattleUSA
  4. 4.Boston Medical Center Section of Hematology OncologyBoston UniversityBostonUSA

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