Adolescent dietary fiber, vegetable fat, vegetable protein, and nut intakes and breast cancer risk
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The importance of early-life exposures in breast cancer development is increasingly recognized. However, limited research has evaluated the relationship between adolescent diet and subsequent risk of breast cancer and reported inconsistent results. This population-based case–control study investigated the associations of dietary fiber, vegetable protein, vegetable fat, and nuts consumed during adolescence with adult breast cancer risk. Women, ages 25–74 years, who were diagnosed with first primary breast cancer between 2002 and 2003, were identified using the Ontario Cancer Registry. Controls were identified through random-digit dialing and age-frequency matched to cases. Diet at ages 10–15 was assessed with a 55-item food frequency questionnaire among 2,865 cases and 3,299 controls. Logistic regression was performed to estimate odds ratios (ORs) and 95 % confidence intervals (CIs). Inverse associations were found between intakes of dietary fiber, vegetable protein, vegetable fat, and nuts during adolescence and breast cancer risk, which persisted after controlling for adult intakes. The ORs (95 % CI) for the highest versus the lowest quintile of intake were 0.66 (0.55–0.78; P trend < 0.0001) for fiber, 0.80 (0.68–0.95; P trend = 0.01) for vegetable protein, 0.74 (0.63–0.87; P trend = 0.002) for vegetable fat, and 0.76 (0.61–0.95 for ≥1 serving/day vs. <1 serving/month intake; P trend = 0.04) for nuts. The reduced risk for adolescent intakes of fiber, vegetable protein, and nuts was largely limited to postmenopausal women (P interaction ≤ 0.05). Dietary fiber, vegetable protein, vegetable fat, and nuts consumed during adolescence were associated with reduced breast cancer risk.
KeywordsBreast cancer Diet Adolescence Nutrition
YL and GAC are supported by the Barnes-Jewish Hospital Foundation, St. Louis, Missouri. GAC is also supported by the Breast Cancer Research Foundation. This research was funded by the Canadian Breast Cancer Research Alliance with special funding support of the Canadian Breast Cancer Foundation Ontario Chapter (CBCRA Grant No. 13572 to M. Cotterchio).
Conflict of interest
The authors declare that they have no conflict of interest.
- 14.Meier-Abt F, Milani E, Roloff T, Brinkhaus H, Duss S, Meyer DS, Klebba I, Balwierz PJ, van Nimwegen E, Bentires-Alj M (2013) Parity induces differentiation and reduces Wnt/Notch signaling ratio and proliferation potential of basal stem/progenitor cells isolated from mouse mammary epithelium. Breast Cancer Res 15:R36PubMedCentralPubMedCrossRefGoogle Scholar
- 25.U.S. Department of Agriculture, Agricultural Research Service (2007) USDA National Nutrient Database for Standard Reference, Release 25. Nutrient Data Laboratory Home Page. http://www.ars.usda.gov/services/docs.htm?docid=8964. Accessed 14 June 2013
- 28.Thompson FE, Subar AF (2001) Dietary assessment methodology. In: Coulston AM, Rock CL, Monsen ER (eds) Nutrition in the prevention and treatment of disease, 2nd edn. Academic Press, San DiegoGoogle Scholar
- 33.Dorgan JF, Hunsberger SA, McMahon RP, Kwiterovich PO Jr, Lauer RM, Van Horn L, Lasser NL, Stevens VJ, Friedman LA, Yanovski JA, Greenhut SF, Chandler DW, Franklin FA, Barton BA, Buckman DW, Snetselaar LG, Patterson BH, Schatzkin A, Taylor PR (2003) Diet and sex hormones in girls: findings from a randomized controlled clinical trial. J Natl Cancer Inst 95:132–141PubMedCrossRefGoogle Scholar
- 34.Dorgan JF, Liu L, Klifa C, Hylton N, Shepherd JA, Stanczyk FZ, Snetselaar LG, Van Horn L, Stevens VJ, Robson A, Kwiterovich PO Jr, Lasser NL, Himes JH, Pettee Gabriel K, Kriska A, Ruder EH, Fang CY, Barton BA (2010) Adolescent diet and subsequent serum hormones, breast density, and bone mineral density in young women: results of the Dietary Intervention Study in Children follow-up study. Cancer Epidemiol Biomarkers Prev 19:1545–1556PubMedCentralPubMedCrossRefGoogle Scholar
- 43.Kushi LH, Doyle C, McCullough M, Rock CL, Demark-Wahnefried W, Bandera EV, Gapstur S, Patel AV, Andrews K, Gansler T (2012) American Cancer Society Guidelines on nutrition and physical activity for cancer prevention: reducing the risk of cancer with healthy food choices and physical activity. CA Cancer J Clin 62:30–67PubMedCrossRefGoogle Scholar