Steroid hormone receptor expression in breast cancer stroma
- 235 Downloads
To the Editor,
Around two-thirds of all breast carcinomas respond to adjuvant endocrine therapy with the presence of ERα in tumour epithelial cells used to guide therapy. Other members of the steroid receptor superfamily have also been detected in breast cancer epithelial cells, notably PR, AR, whose presence and potential prognostic role in breast cancer is gaining momentum [1, 2], and there is ongoing interest in the potential role of ERβ in breast carcinogenesis . However, scientists are now looking beyond the epithelial landscape with the recognition that interaction of tumour epithelial cells with its surrounding microenvironment, particularly the stroma plays a role in promoting tumour growth and progression. While recognising that the stroma is multicellular, much of this attention has focused on fibroblasts residing in tumour stroma, termed carcinoma-associated fibroblasts (CAFs) as there is growing appreciation that CAFs may provide a favourable environment to augment...
KeywordsBreast Carcinogenesis Tumour Epithelial Cell Breast Cancer Epithelial Cell Steroid Hormone Receptor Expression Steroid Receptor Superfamily
MEB is a Leeds Undergraduate Research Enterprise scholar.
- 5.Knower KC, Chand AL, Eriksson N, Takagi K, Miki Y, Sasano H, Visvader JE, Lindeman GJ, Funder JW, Fuller PJ, Simpson ER, Tilley WD, Leedman P, Graham JD, Muscat GE, Clarke CL, Clyne CD (2013) Distinct nuclear receptor expression in stroma adjacent to breast tumors. Breast Cancer Res Treat 142:211–223PubMedCrossRefGoogle Scholar
- 8.Shaaban AM, Green AR, Karthik S, Alizadeh Y, Hughes TA, Harkins L, Ellis IO, Robertson JF, Paish EC, Saunders PTK, Groome NP, Speirs V (2008) Nuclear and cytoplasmic expression of ERβ1, -2 and -5 identifies distinct prognostic outcome for breast cancer patients. Clin Cancer Res 14:5228–5235PubMedCrossRefGoogle Scholar