Patients’ willingness to participate in a breast cancer biobank at screening mammogram
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To characterize patients’ willingness to donate a biospecimen for future research as part of a breast cancer-related biobank involving a general screening population. We performed a prospective cross-sectional study of 4,217 women aged 21–89 years presenting to our facilities for screening mammogram between December 2010 and October 2011. This HIPAA-compliant study was approved by our institutional review board. We collected data on patients’ interest in and actual donation of a biospecimen, motivators and barriers to donating, demographic information, and personal breast cancer risk factors. A multivariate logistic regression analysis was performed to identify patient-level characteristics associated with an increased likelihood to donate. Mean patient age was 57.8 years (SD 11.1 years). While 66.0 % (2,785/4,217) of patients were willing to donate blood or saliva during their visit, only 56.4 % (2,378/4,217) actually donated. Women with a college education (OR = 1.27, p = 0.003), older age (OR = 1.02, p < 0.001), previous breast biopsy (OR = 1.23, p = 0.012), family history of breast cancer (OR = 1.23, p = 0.004), or a comorbidity (OR = 1.22, p = 0.014) were more likely to donate. Asian-American women were significantly less likely to donate (OR = 0.74, p = 0.005). The major reason for donating was to help all future patients (42.3 %) and the major reason for declining donation was privacy concerns (22.3 %). A large proportion of women participating in a breast cancer screening registry are willing to donate blood or saliva to a biobank. Among minority participants, Asian-American women are less likely to donate and further qualitative research is required to identify novel active recruitment strategies to insure their involvement.
KeywordsBiospecimen Biobank Breast cancer Screening Patient willingness
Christoph I. Lee, MD, MSHS received support from the Robert Wood Johnson Foundation Clinical Scholars Program, and the National Institutes of Health (NIH)/National Institute for Minority Health and Health Disparities LRP. Carol Mangione, MD, MSPH received support from the UCLA Resource Centers for Minority Aging Research Center for Health Improvement of Minority Elderly (RCMAR/CHIME) under NIH/NIA Grant P30-AG021684 and the NIH/NCATS UCLA CTSI Grant Number UL1TR000124. Arash Naeim, MD, PhD received support from the UC Office of the President and the Safeway Foundation in support of the Athena Breast Network, and by a grant from the California Breast Cancer Research Foundation. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH and other funding organizations.
Conflict of interest
All authors declare no financial conflicts of interest related to this study.
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