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Breast Cancer Research and Treatment

, Volume 136, Issue 2, pp 615–616 | Cite as

Close association between genotypes of the Val158Met polymorphism and pain perception in pain patients besides breast cancer patients

Letter to the Editor
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Keywords

Fibromyalgia Breast Cancer Survivor Personality Disorder Pain Patient Tension Type Headache 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Conflict of interest

No conflict of interest.

References

  1. 1.
    Fernandez-de-Las-Penas C, Fernandez-Lao C, Cantarero-Villanueva I et al (2012) Catechol-O-methyltransferase genotype (Val158met) modulates cancer-related fatigue and pain sensitivity in breast cancer survivors. Breast Cancer Res Treat 133:405–412PubMedCrossRefGoogle Scholar
  2. 2.
    Zubieta JK, Heitzeg MM, Smith YR et al (2003) COMT val158met genotype affects mu-opioid neurotransmitter responses to a pain stressor. Science 299:1240–1243PubMedCrossRefGoogle Scholar
  3. 3.
    Rakvag TT, Klepstad P, Baar C et al (2005) The Val158Met polymorphism of the human catechol-O-methyltransferase (COMT) gene may influence morphine requirements in cancer pain patients. Pain 116:73–78PubMedCrossRefGoogle Scholar
  4. 4.
    Schmahl C, Ludascher P, Greffrath W et al (2012) COMT val158met polymorphism and neural pain processing. PLoS ONE 7:e23658PubMedCrossRefGoogle Scholar

References for Rebuttal letter

  1. 1.
    Fernández-de-las-Peñas C, Fernández-Lao C, Cantarero-Villanueva I, et al. (2012) Catechol-O-methyltransferase genotype (Val158met) modulates cancer-related fatigue and pain sensitivity in breast cancer survivors. Breast Cancer Res Treat 133:405–412PubMedCrossRefGoogle Scholar
  2. 2.
    Lee YH, Choi SJ, Ji JD, Song GG (2012) Candidate gene studies of fibromyalgia: a systematic review and meta-analysis. Rheumatol Int 32:417–426PubMedCrossRefGoogle Scholar
  3. 3.
    Hagen K, Pettersen E, Stovner LJ, Skorpen F, Zwart JA (2006) The association between headache and Val158Met polymorphism in the catechol-O-methyltransferase gene: the HUNT study. J Headache Pain 7:70–74PubMedCrossRefGoogle Scholar
  4. 4.
    Armero P, Muriel C, Santos J, Sanchez-Montero FJ, Rodriguez RE, Gonzalez-Sarmiento R (2005) COMT (Val158Met) polymorphism is not associated to neuropathic pain in a Spanish population. Eur J Pain 9:229–232PubMedCrossRefGoogle Scholar
  5. 5.
    Hagen K, Pettersen E, Stovner LJ, Skorpen F, Zwart JA ( 2006) No association between chronic musculoskeletal complaints and Val158Met polymorphism in the Catechol-O-methyltransferase gene: the HUNT study. BMC Musculoskelet Disord 7:40PubMedCrossRefGoogle Scholar
  6. 6.
    Fernández-de-las-Peñas C, Ambite-Quesada S, Rivas-Martínez I et al (2011) Genetic contribution of catechol-O-methyltransferase polymorphism (Val158Met) in children with chronic tension-type headache. Pediatr Res 70:395–399PubMedCrossRefGoogle Scholar
  7. 7.
    Fernández-de-las-Peñas C, Ambite-Quesada S, Gil-Crujera A, Cigarán-Méndez M, Peñacoba-Puente C (2012) Catechol-O-Methyltransferase Val158Met polymorphism influence anxiety, depression and disability, but not pressure pain sensitivity, in women with fibromialgia syndrome. J Pain (in press)Google Scholar

Copyright information

© Springer Science+Business Media, LLC. 2012

Authors and Affiliations

  1. 1.SchaumburgUSA

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