Breast Cancer Research and Treatment

, Volume 135, Issue 1, pp 321–323 | Cite as

Breast fat and breast cancer

Letter To the Editor


Breast Cancer Breast Cancer Risk Mammographic Density Dense Area Postmenopausal Breast Cancer 



We thank Drs. Pagona Lagiou and Dimitrios Trichopoulos for valuable suggestions on the manuscript.

Conflict of interest



  1. 1.
    Pettersson A, Hankinson SE, Willett WC, Lagiou P, Trichopoulos D, Tamimi RM (2011) Nondense mammographic area and risk of breast cancer. Breast Cancer Res 13(5):R100PubMedCrossRefGoogle Scholar
  2. 2.
    Byrne C, Schairer C, Wolfe J et al (1995) Mammographic features and breast cancer risk: effects with time, age, and menopause status. J Natl Cancer Inst 87(21):1622–1629PubMedCrossRefGoogle Scholar
  3. 3.
    McCormack VA, dos Santos Silva I (2006) Breast density and parenchymal patterns as markers of breast cancer risk: a meta-analysis. Cancer Epidemiol Biomarkers Prev 15(6):1159–1169PubMedCrossRefGoogle Scholar
  4. 4.
    Trichopoulos D, Lipman RD (1992) Mammary gland mass and breast cancer risk. Epidemiology 3(6):523–526PubMedCrossRefGoogle Scholar
  5. 5.
    Stuedal A, Ma H, Bernstein L, Pike MC, Ursin G (2008) Does breast size modify the association between mammographic density and breast cancer risk? Cancer Epidemiol Biomarkers Prev 17(3):621–627PubMedCrossRefGoogle Scholar
  6. 6.
    Lokate M, Peeters PH, Peelen LM, Haars G, Veldhuis WB, van Gils CH (2011) Mammographic density and breast cancer risk: the role of the fat surrounding the fibroglandular tissue. Breast Cancer Res 13(5):R103PubMedCrossRefGoogle Scholar
  7. 7.
    Stone J, Ding J, Warren RM, Duffy SW, Hopper JL (2010) Using mammographic density to predict breast cancer risk: dense area or percentage dense area. Breast Cancer Res 12(6):R97Google Scholar
  8. 8.
    Torres-Mejia G, De Stavola B, Allen DS et al (2005) Mammographic features and subsequent risk of breast cancer: a comparison of qualitative and quantitative evaluations in the Guernsey prospective studies. Cancer Epidemiol Biomarkers Prev 14(5):1052–1059PubMedCrossRefGoogle Scholar
  9. 9.
    Renehan AG, Tyson M, Egger M, Heller RF, Zwahlen M (2008) Body-mass index and incidence of cancer: a systematic review and meta-analysis of prospective observational studies. Lancet 371(9612):569–578PubMedCrossRefGoogle Scholar
  10. 10.
    Key TJ, Appleby PN, Reeves GK et al (2003) Body mass index, serum sex hormones, and breast cancer risk in postmenopausal women. J Natl Cancer Inst 95(16):1218–1226PubMedCrossRefGoogle Scholar
  11. 11.
    Rose DP, Vona-Davis L (2010) Interaction between menopausal status and obesity in affecting breast cancer risk. Maturitas 66(1):33–38PubMedCrossRefGoogle Scholar
  12. 12.
    Boyd NF, Martin LJ, Sun L et al (2006) Body size, mammographic density, and breast cancer risk. Cancer Epidemiol Biomarkers Prev 15(11):2086–2092PubMedCrossRefGoogle Scholar
  13. 13.
    Harris HR, Tamimi RM, Willett WC, Hankinson SE, Michels KB (2011) Body size across the life course, mammographic density, and risk of breast cancer. Am J Epidemiol 174(8):909–918PubMedCrossRefGoogle Scholar
  14. 14.
    Hovey RC, Aimo L (2010) Diverse and active roles for adipocytes during mammary gland growth and function. J Mammary Gland Biol Neoplasia 15(3):279–290PubMedCrossRefGoogle Scholar
  15. 15.
    Ching S, Kashinkunti S, Niehaus MD, Zinser GM (2011) Mammary adipocytes bioactivate 25-hydroxyvitamin D and signal via vitamin D receptor, modulating mammary epithelial cell growth. J Cell Biochem 112(11):3393–3405PubMedCrossRefGoogle Scholar
  16. 16.
    Beer AE, Billingham RE (1978) Adipose tissue, a neglected factor in aetiology of breast cancer? Lancet 2(8084):296PubMedCrossRefGoogle Scholar
  17. 17.
    Levental KR, Yu H, Kass L et al (2009) Matrix crosslinking forces tumor progression by enhancing integrin signaling. Cell 139(5):891–906PubMedCrossRefGoogle Scholar
  18. 18.
    Paszek MJ, Zahir N, Johnson KR et al (2005) Tensional homeostasis and the malignant phenotype. Cancer Cell 8(3):241–254PubMedCrossRefGoogle Scholar
  19. 19.
    Provenzano PP, Inman DR, Eliceiri KW, Keely PJ (2009) Matrix density-induced mechanoregulation of breast cell phenotype, signaling and gene expression through a FAK-ERK linkage. Oncogene 28(49):4326–4343PubMedCrossRefGoogle Scholar
  20. 20.
    Ronnov-Jessen L, Bissell MJ (2009) Breast cancer by proxy: can the microenvironment be both the cause and consequence? Trends Mol Med 15(1):5–13PubMedCrossRefGoogle Scholar
  21. 21.
    Brower V (2010) Homing in on mechanisms linking breast density to breast cancer risk. J Natl Cancer Inst 102(12):843–845PubMedCrossRefGoogle Scholar
  22. 22.
    Butcher DT, Alliston T, Weaver VM (2009) A tense situation: forcing tumour progression. Nat Rev Cancer 9(2):108–122PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC. 2012

Authors and Affiliations

  1. 1.Department of EpidemiologyHarvard School of Public HealthBostonUSA
  2. 2.Channing Laboratory, Department of MedicineBrigham and Women’s Hospital and Harvard Medical SchoolBostonUSA

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