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Breast Cancer Research and Treatment

, Volume 132, Issue 1, pp 341–345 | Cite as

Lack of association between common single nucleotide polymorphisms in the TERT-CLPTM1L locus and breast cancer in women of African ancestry

  • Yonglan Zheng
  • Temidayo O. Ogundiran
  • Clement Adebamowo
  • Katherine L. Nathanson
  • Susan M. Domchek
  • Timothy R. Rebbeck
  • Michael S. Simon
  • Esther M. John
  • Anselm Hennis
  • Barbara Nemesure
  • Suh-Yuh Wu
  • Maria Cristina Leske
  • Stefan Ambs
  • Qun Niu
  • Jing Zhang
  • Nancy J. Cox
  • Olufunmilayo I. Olopade
  • Dezheng Huo
Brief Report

Abstract

As one of the most common cancers worldwide, breast cancer places an extraordinary burden on the populations of African ancestry. Common SNPs in the TERT-CLPTM1L locus have been reported to be associated with several types of cancer, including breast cancer. We sought to investigate whether the previously reported common single nucleotide polymorphisms (SNPs) in the TERT-CLPTM1L locus could also contribute to the breast cancer risk in women of African ancestry. We genotyped eleven SNPs in 2,892 women of African descent but were unable to detect any significant association between TERT-CLPTM1L SNPs and their predispositions for breast cancer risk. Given the differences in linkage disequilibrium patterns across populations, our findings suggest that larger independent studies from diverse populations are expected to evaluate the importance of the TERT-CLPTM1L locus in breast cancer.

Keywords

TERT-CLPTM1L Single nucleotide polymorphism Association Breast cancer African ancestry 

Notes

Acknowledgment

This study was supported by grants from the National Cancer Institute at the United States National Institutes of Health (R01 CA141712, R01 CA142996-01, P50 CA125183), Entertainment Industry Foundation, Falk Medical Research Trust, Susan G Komen for the Cure, and Breast Cancer Research Foundation. The Northern California site of the Breast Cancer Family Registry (BCFR) was supported by the United States National Cancer Institute, National Institutes of Health (NIH) under RFA-CA-06-503 and through cooperative agreements with members of the BCFR and Principal Investigators, including the Northern California Cancer Center (U01 CA69417). Samples from the Northern California site were processed and distributed by the Coriell Institute for Medical Research. The content of this manuscript does not necessarily reflect the views or policies of the National Cancer Institute or any of the collaborating centers in the BCFR, nor does mention of trade names, commercial products, or organizations imply endorsement by the US Government or the BCFR.

Conflict of interest

The authors declare no conflict of interest.

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Copyright information

© Springer Science+Business Media, LLC. 2011

Authors and Affiliations

  • Yonglan Zheng
    • 1
  • Temidayo O. Ogundiran
    • 2
  • Clement Adebamowo
    • 3
  • Katherine L. Nathanson
    • 4
  • Susan M. Domchek
    • 4
  • Timothy R. Rebbeck
    • 5
  • Michael S. Simon
    • 6
  • Esther M. John
    • 7
    • 8
  • Anselm Hennis
    • 9
  • Barbara Nemesure
    • 10
  • Suh-Yuh Wu
    • 10
  • Maria Cristina Leske
    • 10
  • Stefan Ambs
    • 11
  • Qun Niu
    • 12
  • Jing Zhang
    • 12
  • Nancy J. Cox
    • 12
  • Olufunmilayo I. Olopade
    • 12
  • Dezheng Huo
    • 13
  1. 1.Department of MedicineThe University of ChicagoChicagoUSA
  2. 2.Department of Surgery, College of MedicineUniversity of IbadanIbadanNigeria
  3. 3.Department of Epidemiology & Preventive MedicineUniversity of MarylandBaltimoreUSA
  4. 4.Department of MedicineUniversity of PennsylvaniaPhiladelphiaUSA
  5. 5.Department of Statistics & EpidemiologyUniversity of PennsylvaniaPhiladelphiaUSA
  6. 6.Department of OncologyKarmanos Cancer Institute, Wayne State UniversityDetroitUSA
  7. 7.Cancer Prevention Institute of CaliforniaFremontUSA
  8. 8.Department of Health Research & PolicyStanford University School of Medicine and Stanford Cancer InstituteStanfordUSA
  9. 9.Chronic Disease Research Centre and Tropical Medicine Research InstituteUniversity of the West IndiesBridgetownBarbados
  10. 10.Department of Preventive MedicineState University of New York at Stony BrookStony BrookUSA
  11. 11.Laboratory of Human CarcinogenesisNational Cancer InstituteBethesdaUSA
  12. 12.Department of MedicineThe University of ChicagoChicagoUSA
  13. 13.Department of Health StudiesThe University of ChicagoChicagoUSA

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