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A comparison of quality of life of early breast cancer patients treated with accelerated partial breast irradiation versus whole breast irradiation in China

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Abstract

To compare quality of life (QoL) of early breast cancer patients treated with either accelerated partial breast irradiation (APBI) or whole breast irradiation (WBI) after breast-conserving therapy in China. The functional assessment of chronic illness therapy—Breast, traditional Chinese version 4 (FACT-B) instruments were given to 84 women (31 APBI and 53 WBI) who attended the radiotherapy clinic between July 2006 and May 2009 at Cancer Center of Sun Yat-sen University. Baseline characteristics and Karnofsky performance status scores were not different between the two groups. The median follow-up period in the APBI group was 29 versus 34 months in the WBI group. The APBI group scores in the physical domain, functional domain, social domain, and breast-specific concerns of FACT-B were 23.01 ± 3.91, 17.97 ± 4.99, 20.87 ± 4.80, and 22.55 ± 5.45, respectively, and were not significantly different from those of the WBI group (22.80 ± 3.50, 17.50 ± 4.40, 20.13 ± 5.31, 23.81 ± 4.65, respectively, P = 0.987, P = 0.476, P = 0.442, P = 0.330, respectively). However, the scores of the APBI group with respect to the emotional domains were lower compared to those of the WBI group (16.84 ± 3.86 vs. 19.47 ± 3.45, respectively, P = 0.002). Compared with women who underwent WBI, women treated with APBI were shown to have no significantly better QoL outcome, and yet had worse emotional response to their treatment.

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Authors and Affiliations

  1. State Key Laboratory of Oncology in Southern China, Department of Radiation Oncology, Cancer Center of Sun Yat-sen University, 651 Dongfeng Road East, Guangzhou, 510060, People’s Republic of China

    Zhen-Yu He, San-Gang Wu, Feng-Yan Li, Huan-Xin Lin & Xun-Xing Guan

  2. Department Of Radiation Oncology, Cancer Center, The First Affiliated Hosptial Of Nanhua University, Hengyang, China

    Qin Tong

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  1. Zhen-Yu He
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Correspondence to Xun-Xing Guan.

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He, ZY., Tong, Q., Wu, SG. et al. A comparison of quality of life of early breast cancer patients treated with accelerated partial breast irradiation versus whole breast irradiation in China. Breast Cancer Res Treat 133, 545–552 (2012). https://doi.org/10.1007/s10549-011-1793-7

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  • DOI: https://doi.org/10.1007/s10549-011-1793-7

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