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Breast Cancer Research and Treatment

, Volume 133, Issue 2, pp 545–552 | Cite as

A comparison of quality of life of early breast cancer patients treated with accelerated partial breast irradiation versus whole breast irradiation in China

  • Zhen-Yu He
  • Qin Tong
  • San-Gang Wu
  • Feng-Yan Li
  • Huan-Xin Lin
  • Xun-Xing Guan
Preclinical study

Abstract

To compare quality of life (QoL) of early breast cancer patients treated with either accelerated partial breast irradiation (APBI) or whole breast irradiation (WBI) after breast-conserving therapy in China. The functional assessment of chronic illness therapy—Breast, traditional Chinese version 4 (FACT-B) instruments were given to 84 women (31 APBI and 53 WBI) who attended the radiotherapy clinic between July 2006 and May 2009 at Cancer Center of Sun Yat-sen University. Baseline characteristics and Karnofsky performance status scores were not different between the two groups. The median follow-up period in the APBI group was 29 versus 34 months in the WBI group. The APBI group scores in the physical domain, functional domain, social domain, and breast-specific concerns of FACT-B were 23.01 ± 3.91, 17.97 ± 4.99, 20.87 ± 4.80, and 22.55 ± 5.45, respectively, and were not significantly different from those of the WBI group (22.80 ± 3.50, 17.50 ± 4.40, 20.13 ± 5.31, 23.81 ± 4.65, respectively, P = 0.987, P = 0.476, P = 0.442, P = 0.330, respectively). However, the scores of the APBI group with respect to the emotional domains were lower compared to those of the WBI group (16.84 ± 3.86 vs. 19.47 ± 3.45, respectively, P = 0.002). Compared with women who underwent WBI, women treated with APBI were shown to have no significantly better QoL outcome, and yet had worse emotional response to their treatment.

Keywords

Quality of life (QoL) Accelerated partial breast irradiation (APBI) Whole breast irradiation (WBI) Breast cancer 

Notes

Conflict of interest

No any actual or potential conflicts of interest exist.

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Copyright information

© Springer Science+Business Media, LLC. 2011

Authors and Affiliations

  • Zhen-Yu He
    • 1
  • Qin Tong
    • 2
  • San-Gang Wu
    • 1
  • Feng-Yan Li
    • 1
  • Huan-Xin Lin
    • 1
  • Xun-Xing Guan
    • 1
  1. 1.State Key Laboratory of Oncology in Southern China, Department of Radiation OncologyCancer Center of Sun Yat-sen UniversityGuangzhouPeople’s Republic of China
  2. 2.Department Of Radiation Oncology, Cancer CenterThe First Affiliated Hosptial Of Nanhua UniversityHengyangChina

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