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Breast Cancer Research and Treatment

, Volume 129, Issue 3, pp 1011–1013 | Cite as

Data in a recent meta-analysis about TNF-alpha polymorphisms and breast cancer susceptibility need for clarification

  • Min-Bin Chen
  • Jin-Hua Gu
  • Xiao-Yang Wu
  • Pei-Hua Lu
  • Rong-Min Gu
Letter to the Editor
  • 106 Downloads

To the Editor,

We have read with great interest the article ‘‘TNF-alpha polymorphisms and breast cancer’’ published in April 2011 issue of “Breast Cancer Research and Treatment”. Yang et al. [1] identified a total of 17 studies with 44,442 breast cancer patients and 49,926 controls involved, and performed a meta-analysis to examine the association between tumor necrosis factor-alpha (TNF-alpha) gene polymorphisms and breast cancer susceptibility. The results indicated that the TNF-alpha-308, -238, -857, -863, -1031, and -1210 polymorphisms were not associated with the risk for BC in overall populations, whereas a negative association was found between TNF-alpha-308 polymorphism and BC in Caucasian populations. Nevertheless, some methodological issues need to be addressed concerning the data provided in the meta-analysis by Yang et al. [1]. We would like to comment and raise some concerns.

First, the ethnicity reported by Yang et al. [1] for the studies Skerrett et al. [2] and Erdel et...

Keywords

Breast Cancer Breast Cancer Patient Cord Blood Asian Population Caucasian Population 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. 1.
    Yang Y, Feng R, Bi S, Xu Y (2011) TNF-alpha polymorphisms and breast cancer. Breast Cancer Res Treat. doi: 10.1007/s10549-011-1494-2
  2. 2.
    Skerrett DL, Moore EM, Bernstein DS, Vahdat L (2005) Cytokine genotype polymorphisms in breast carcinoma: associations of TGF-beta1 with relapse. Cancer Invest 23:208–214PubMedCrossRefGoogle Scholar
  3. 3.
    Erdei E, Kang H, Meisner A, White K, Pickett G, Baca C, Royce M, Berwick M (2010) Polymorphisms in cytokine genes and serum cytokine levels among New Mexican women with and without breast cancer. Cytokine 51:18–24PubMedCrossRefGoogle Scholar
  4. 4.
    Shen C, Sun H, Sun D, Xu L, Zhang X, Liu A, Jia X, Bai J, Chen F, Yu Y, Jin Y, Yu J, Fu S (2011) Polymorphisms of tumor necrosis factor-alpha and breast cancer risk: a meta-analysis. Breast Cancer Res Treat 126:763–770PubMedCrossRefGoogle Scholar
  5. 5.
    Mestiri S, Bouaouina N, Ahmed SB, Khedhaier A, Jrad BB, Remadi S, Chouchane L (2001) Genetic variation in the tumor necrosis factor-alpha promoter region and in the stress protein hsp70-2: susceptibility and prognostic implications in breast carcinoma. Cancer 91:672–678PubMedCrossRefGoogle Scholar
  6. 6.
    Kamali-Sarvestani E, Merat A, Talei AR (2005) Polymorphism in the genes of alpha and beta tumor necrosis factors (TNF-alpha and TNF-beta) and gamma interferon (IFN-gamma) among Iranian women with breast cancer. Cancer Lett 223:113–119PubMedCrossRefGoogle Scholar

References for Rebuttal letter

  1. 1.
    Skerrett DL, Moore EM, Bernstein DS, Vahdat L (2005) Cytokine genotype polymorphisms in breast carcinoma: associations of TGF-beta1 with relapse. Cancer Invest 23:208–214PubMedCrossRefGoogle Scholar
  2. 2.
    Erdei E, Kang H, Meisner A, White K, Pickett G, Baca C et al (2010) Polymorphisms in cytokine genes and serum cytokine levels among New Mexican women with and without breast cancer. Cytokine 51:18–24PubMedCrossRefGoogle Scholar
  3. 3.
    Mestiri S, Bouaouina N, Ahmed SB, Khedhaier A, Jrad BB, Remadi S et al (2001) Genetic variation in the tumor necrosis factor-alpha promoter region and in the stress protein hsp70-2: susceptibility and prognostic implications in breast carcinoma. Cancer 91:672–678PubMedCrossRefGoogle Scholar
  4. 4.
    Kamali-Sarvestani E, Merat A, Talei AR (2005) Polymorphism in the genes of alpha and beta tumor necrosis factors (TNF-alpha and TNF-beta) and gamma interferon (IFN-gamma) among Iranian women with breast cancer. Cancer Lett 223:113–119PubMedCrossRefGoogle Scholar
  5. 5.
    Yang Y, Feng R, Bi S, Xu Y (2011) TNF-alpha polymorphisms and breast cancer. Breast Cancer Res Treat. doi: 10.1007/s10549-011-1494-2

Copyright information

© Springer Science+Business Media, LLC. 2011

Authors and Affiliations

  • Min-Bin Chen
    • 1
  • Jin-Hua Gu
    • 2
  • Xiao-Yang Wu
    • 3
  • Pei-Hua Lu
    • 4
  • Rong-Min Gu
    • 5
  1. 1.Department of Medical OncologyKunshan First People’s Hospital Affiliated to Jiangsu UniversityKunshanChina
  2. 2.Department of Medical Laboratory CenterKunshan First People’s Hospital Affiliated to Jiangsu UniversityKunshanChina
  3. 3.Department of Surgical OncologyKunshan First People’s Hospital Affiliated to Jiangsu UniversityKunshanChina
  4. 4.Department of SurgeryWuxi People’s Hospital affiliated to Nanjing Medical UniversityWuxiChina
  5. 5.Department of SurgeryNanjing Medical University Affiliated Cancer Hospital of Jiangsu ProvinceNanjingChina

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