Data in a recent meta-analysis about TNF-alpha polymorphisms and breast cancer susceptibility need for clarification
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To the Editor,
We have read with great interest the article ‘‘TNF-alpha polymorphisms and breast cancer’’ published in April 2011 issue of “Breast Cancer Research and Treatment”. Yang et al.  identified a total of 17 studies with 44,442 breast cancer patients and 49,926 controls involved, and performed a meta-analysis to examine the association between tumor necrosis factor-alpha (TNF-alpha) gene polymorphisms and breast cancer susceptibility. The results indicated that the TNF-alpha-308, -238, -857, -863, -1031, and -1210 polymorphisms were not associated with the risk for BC in overall populations, whereas a negative association was found between TNF-alpha-308 polymorphism and BC in Caucasian populations. Nevertheless, some methodological issues need to be addressed concerning the data provided in the meta-analysis by Yang et al. . We would like to comment and raise some concerns.
KeywordsBreast Cancer Breast Cancer Patient Cord Blood Asian Population Caucasian Population
- 1.Yang Y, Feng R, Bi S, Xu Y (2011) TNF-alpha polymorphisms and breast cancer. Breast Cancer Res Treat. doi: 10.1007/s10549-011-1494-2
References for Rebuttal letter
- 5.Yang Y, Feng R, Bi S, Xu Y (2011) TNF-alpha polymorphisms and breast cancer. Breast Cancer Res Treat. doi: 10.1007/s10549-011-1494-2