Association of XPC polymorphisms with breast cancer risk

  • Feng Xu
  • Dewu Zhong
  • Zhonghua Tang
  • Meirong Zhou
  • Yu Zhu
Letter to the Editor

To the Editor,

We read with great interest the article by Zheng W et al. [1], which assessed the association between Xeroderma Pigmentosum group C (XPC) polymorphisms and breast cancer risk with a meta-analysis. The results suggested that there was no significant association between either Lys939Gln or Ala499Val polymorphism and breast cancer risk in any genetic model or any subgroup based on ethnicity/source of controls. However, a significant association was observed for PAT ± polymorphism under a recessive model (odds ratio 1.41, 95% confidence interval 1.05–1.89). After carefully reading the article, we noted several methodological issues which should be considered.

First, in the “Publication search”, they did not state whether there was language restriction for the study identification. In addition, in our opinion, “Xeroderma Pigmentosum group C”, the full name of “XPC” also should be used as one of the search terms, to search all relevant potential studies.

Second, they did not...


Breast Cancer Risk Genotype Frequency Genetic Model Weinberg Equilibrium Methodological Issue 
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Copyright information

© Springer Science+Business Media, LLC. 2011

Authors and Affiliations

  • Feng Xu
    • 1
  • Dewu Zhong
    • 1
  • Zhonghua Tang
    • 1
  • Meirong Zhou
    • 1
  • Yu Zhu
    • 2
  1. 1.Department of Breast SurgeryThe Second Xiangya Hospital of Central South UniversityChangshaChina
  2. 2.Department of Epidemiology and Biostatistics, School of Public HealthAnhui Medical UniversityHefeiChina

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