Association of XPC polymorphisms with breast cancer risk
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To the Editor,
We read with great interest the article by Zheng W et al. , which assessed the association between Xeroderma Pigmentosum group C (XPC) polymorphisms and breast cancer risk with a meta-analysis. The results suggested that there was no significant association between either Lys939Gln or Ala499Val polymorphism and breast cancer risk in any genetic model or any subgroup based on ethnicity/source of controls. However, a significant association was observed for PAT ± polymorphism under a recessive model (odds ratio 1.41, 95% confidence interval 1.05–1.89). After carefully reading the article, we noted several methodological issues which should be considered.
First, in the “Publication search”, they did not state whether there was language restriction for the study identification. In addition, in our opinion, “Xeroderma Pigmentosum group C”, the full name of “XPC” also should be used as one of the search terms, to search all relevant potential studies.
KeywordsBreast Cancer Risk Genotype Frequency Genetic Model Weinberg Equilibrium Methodological Issue
- 1.Zheng W, Cong XF, Cai WH, Yang S, Mao C, Zou HW (2011) Current evidences on XPC polymorphisms and breast cancer susceptibility: a meta-analysis. Breast Cancer Res Treat. doi: 10.1007/s10549-011-1369-6
- 4.Shen J, Gammon MD, Terry MB, Teitelbaum SL, Eng SM, Neugut AI (2008) Xeroderma pigmentosum complementation group C genotypes/diplotypes play no independent or interaction role with polycyclic aromatic hydrocarbons-DNA adducts for breast cancer risk. Eur J Cancer 44:710–717PubMedCrossRefGoogle Scholar