Breast Cancer Research and Treatment

, Volume 127, Issue 1, pp 129–131 | Cite as

Neoadjuvant chemotherapy for breast cancer: a surgeon’s checklist

  • Tara M. Breslin
Invited Commentary

Understanding and translating results from the highly regulated and uniform environment of therapeutic trials to everyday patient care are one of the most challenging aspects of maintaining a clinical breast cancer practice. Careful interpretation of study results is of utmost importance when determining whether or not to adopt a new therapy or treatment sequence. Randomized clinical trials investigating neoadjuvant chemotherapy approaches to breast cancer management deserve special attention from surgeons and all members of the multidisciplinary team to obtain the best result and focus patient goals and expectations.

Each patient for whom neoadjuvant chemotherapy is contemplated should undergo a careful physical exam focused on clinical tumor size, tumor mobility, or fixation with respect to skin and chest wall, axillary lymph node status, and a thorough exam of the contralateral breast. As with any newly diagnosed breast cancer, imaging is intended to characterize the index cancer,...


Breast Conservation Postmastectomy Radiotherapy Post Mastectomy Radiotherapy Hormone Responsive Breast Cancer Axillary Nodal Staging 
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  1. 1.
    Goldhirsch A, Wood WC, Gelber RD et al (2003) Meeting highlights: updated international expert consensus on the primary therapy of early breast cancer. J Clin Oncol 21:3357–3365PubMedCrossRefGoogle Scholar
  2. 2.
    Paik S, Shak S, Tang G et al (2004) A multigene assay to predict recurrence of tamoxifen-treated, node-negative breast cancer. N Engl J Med 351:2817–2826PubMedCrossRefGoogle Scholar
  3. 3.
    Kaufmann M, Hortobagyi GN, Goldhirsch A et al (2006) Recommendations from an international expert panel on the use of neoadjuvant (primary) systemic treatment of operable breast cancer: an update. J Clin Oncol 24:1940–1949PubMedCrossRefGoogle Scholar
  4. 4.
    Smith IE, Dowsett M, Ebbs SR et al (2005) Neoadjuvant treatment of postmenopausal breast cancer with anastrozole, tamoxifen, or both in combination: the Immediate Preoperative Anastrozole, Tamoxifen, or Combined with Tamoxifen (IMPACT) multicenter double-blind randomized trial. J Clin Oncol 23:5108–5116PubMedCrossRefGoogle Scholar
  5. 5.
    Buchholz TA, Lehman CD, Harris JR et al (2008) Statement of the science concerning locoregional treatments after preoperative chemotherapy for breast cancer: a National Cancer Institute conference. J Clin Oncol 26:791–797PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC. 2011

Authors and Affiliations

  1. 1.University of MichiganAnn ArborUSA

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