Breast Cancer Research and Treatment

, Volume 127, Issue 2, pp 565–568 | Cite as

Further studies based on better design are needed to explore the association of NPAS2 gene polymorphisms with breast cancer

  • Fang Wang
  • Yan-Feng Zou
Letter to the Editor

To the Editor,

We read with great interest the recent article by Wang et al. [1]. The authors typed a novel functional single nucleotide polymorphism (SNP) (rs3739008) located at 3′UTR of neuronal PAS domain protein 2 (NPAS2) in two case–control studies of both Chinese and Germany populations to test its putative associations with breast cancer (BC) susceptibility. They failed to find any significant associations by different genetic models, and concluded that this SNP was not associated with BC susceptibility. It is an interesting study. Nevertheless, several issues seem worth commenting.

First, the study used a hospital-based case–control design. Hospital-based case–control studies inevitably suffer selection bias [2], therefore, the quality and strength of evidence from the study are relatively low, and the results should be treated with caution. Further studies based on population-based case–control or cohort design are needed to explore the association of the NPAS2gene rs3739008...


Breast Cancer Breast Cancer Single Nucleotide Polymorphism Breast Cancer Risk Breast Cancer Susceptibility 
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This work was supported by grants from the National Natural Science Foundation of China (81001283).

Conflict of interest

All the authors declare no conflict of interest.


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References for Rebuttal Letter

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    Liang J, Chen P, Hu Z, Zhou X, Chen L, Li M, Wang Y, Tang J, Wang H, Shen H (2008) Genetic variants in fibroblast growth factor receptor 2 (FGFR2) contribute to susceptibility of breast cancer in Chinese women. Carcinogenesis 29:2341–2346PubMedCrossRefGoogle Scholar
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Copyright information

© Springer Science+Business Media, LLC. 2011

Authors and Affiliations

  1. 1.Department of OncologyThe First Affiliated Hospital of Anhui Medical UniversityHefeiChina
  2. 2.Department of Epidemiology and Biostatistics, School of Public HealthAnhui Medical UniversityHefeiChina

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