Further studies based on better design are needed to explore the association of NPAS2 gene polymorphisms with breast cancer
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To the Editor,
We read with great interest the recent article by Wang et al. . The authors typed a novel functional single nucleotide polymorphism (SNP) (rs3739008) located at 3′UTR of neuronal PAS domain protein 2 (NPAS2) in two case–control studies of both Chinese and Germany populations to test its putative associations with breast cancer (BC) susceptibility. They failed to find any significant associations by different genetic models, and concluded that this SNP was not associated with BC susceptibility. It is an interesting study. Nevertheless, several issues seem worth commenting.
First, the study used a hospital-based case–control design. Hospital-based case–control studies inevitably suffer selection bias , therefore, the quality and strength of evidence from the study are relatively low, and the results should be treated with caution. Further studies based on population-based case–control or cohort design are needed to explore the association of the NPAS2gene rs3739008...
KeywordsBreast Cancer Breast Cancer Single Nucleotide Polymorphism Breast Cancer Risk Breast Cancer Susceptibility
This work was supported by grants from the National Natural Science Foundation of China (81001283).
Conflict of interest
All the authors declare no conflict of interest.
- 1.Wang F, Hu Z, Yang R, Tang J, Liu Y, Hemminki K, Sutter C, Wappenschmidt B, Niederacher D, Arnold N, Meindl A, Bartram CR, Schmutzler RK, Burwinkel B, Shen H (2010) A variant affecting miRNAs binding in the circadian gene Neuronal PAS domain protein 2 (NPAS2) is not associated with breast cancer risk. Breast Cancer Res Treat. doi: 10.1007/s10549-010-1157-8
References for Rebuttal Letter