VEGF 936C>T polymorphism and breast cancer risk: evidence needed further clarification
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To the Editor,
We have read the meta-analysis by Dongying Gu et al.  with great interest, which was published in your journal recently. Through quantitative analysis, this meta-analysis suggested that VEGF 936C>T polymorphism might not contribute to breast cancer susceptibility. This meta-analysis was well done with perfect methodology. However, two points should be mentioned when we closely inspect this study.
First, at least two eligible studies [2, 3] with 2335 cases and 2397 controls were not included in this meta-analysis according to the inclusion criteria. One study by Pharoah et al.  with 2016 cases and 2107 controls was published in 2007. And the other study by Jakubowska et al.  with 319 cases and 290 controls was published in 2008. Actually, the data of this study was not overlapped with the latter study by Jakubowska et al.  in 2009 when carefully reading the full texts. We believed that the bias would be introduced into the results of the meta-analysis due to...
KeywordsBreast Cancer Breast Cancer Risk Eligible Study Breast Cancer Case Fixed Effect Model
Conflict of interest
All the authors declare no conflict of interest.
- 2.Jakubowska A, Gronwald J, Menkiszak J, Gorski B, Huzarski T, Byrski T, Edler L, Lubinski J, Scott RJ, Hamann U (2008) The VEGF_936_C>T 3′UTR polymorphism reduces BRCA1-associated breast cancer risk in Polish women. Cancer Lett:71–76Google Scholar
References for Rebuttal Letter
- 3.Jakubowska A, Gronwald J, Menkiszak J, Gorski B, Huzarski T, Byrski T, Edler L, Lubinski J, Scott RJ, Hamann U (2008) The VEGF_936_C>T 3′UTR polymorphism reduces BRCA1-associated breast cancer risk in Polish women. Cancer LettGoogle Scholar