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Breast Cancer Research and Treatment

, Volume 127, Issue 2, pp 569–571 | Cite as

VEGF 936C>T polymorphism and breast cancer risk: evidence needed further clarification

  • Liu Liu
  • Fu-Zhou Hua
  • Jia-Qing Cao
  • Pei-Qian Zhu
Letter to the Editor

To the Editor,

We have read the meta-analysis by Dongying Gu et al. [1] with great interest, which was published in your journal recently. Through quantitative analysis, this meta-analysis suggested that VEGF 936C>T polymorphism might not contribute to breast cancer susceptibility. This meta-analysis was well done with perfect methodology. However, two points should be mentioned when we closely inspect this study.

First, at least two eligible studies [2, 3] with 2335 cases and 2397 controls were not included in this meta-analysis according to the inclusion criteria. One study by Pharoah et al. [3] with 2016 cases and 2107 controls was published in 2007. And the other study by Jakubowska et al. [2] with 319 cases and 290 controls was published in 2008. Actually, the data of this study was not overlapped with the latter study by Jakubowska et al. [4] in 2009 when carefully reading the full texts. We believed that the bias would be introduced into the results of the meta-analysis due to...

Keywords

Breast Cancer Breast Cancer Risk Eligible Study Breast Cancer Case Fixed Effect Model 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Conflict of interest

All the authors declare no conflict of interest.

References

  1. 1.
    Gu D, Wang M (2011) VEGF 936C>T polymorphism and breast cancer risk: evidence from 5, 729 cases and 5, 868 controls. Breast Cancer Res Treat 125:489–493PubMedCrossRefGoogle Scholar
  2. 2.
    Jakubowska A, Gronwald J, Menkiszak J, Gorski B, Huzarski T, Byrski T, Edler L, Lubinski J, Scott RJ, Hamann U (2008) The VEGF_936_C>T 3′UTR polymorphism reduces BRCA1-associated breast cancer risk in Polish women. Cancer Lett:71–76Google Scholar
  3. 3.
    Pharoah PD, Tyrer J, Dunning AM, Easton DF, Ponder BA (2007) Association between common variation in 120 candidate genes and breast cancer risk. PLoS Genet 3:e42PubMedCrossRefGoogle Scholar
  4. 4.
    Jakubowska A, Jaworska K, Cybulski C, Janicka A, Szymanska-Pasternak J, Lener M, Narod SA, Lubinski J (2009) Do BRCA1 modifiers also affect the risk of breast cancer in non-carriers? Eur J Cancer 45:837–842PubMedCrossRefGoogle Scholar
  5. 5.
    Lin GT, Tseng HF, Yang CH, Hou MF, Chuang LY, Tai HT, Tai MH, Cheng YH, Wen CH, Liu CS, Huang CJ, Wang CL, Chang HW (2009) Combinational polymorphisms of seven CXCL12-related genes are protective against breast cancer in Taiwan. OMICS 13:165–172PubMedCrossRefGoogle Scholar

References for Rebuttal Letter

  1. 1.
    Pharoah PD, Tyrer J, Dunning AM, Easton DF, Ponder BA (2007) Association between common variation in 120 candidate genes and breast cancer risk. PLoS Genet 3:e42PubMedCrossRefGoogle Scholar
  2. 2.
    Gu D, Wang M (2011) VEGF 936C>T polymorphism and breast cancer risk: evidence from 5, 729 cases and 5, 868 controls. Breast Cancer Res Treat 125:489–493PubMedCrossRefGoogle Scholar
  3. 3.
    Jakubowska A, Gronwald J, Menkiszak J, Gorski B, Huzarski T, Byrski T, Edler L, Lubinski J, Scott RJ, Hamann U (2008) The VEGF_936_C>T 3′UTR polymorphism reduces BRCA1-associated breast cancer risk in Polish women. Cancer LettGoogle Scholar
  4. 4.
    Jakubowska A, Jaworska K, Cybulski C, Janicka A, Szymanska-Pasternak J, Lener M, Narod SA, Lubinski J (2009) Do BRCA1 modifiers also affect the risk of breast cancer in non-carriers? Eur J Cancer 45:837–842PubMedCrossRefGoogle Scholar
  5. 5.
    Lin GT, Tseng HF, Yang CH, Hou MF, Chuang LY, Tai HT, Tai MH, Cheng YH, Wen CH, Liu CS, Huang CJ, Wang CL, Chang HW (2009) Combinational polymorphisms of seven CXCL12-related genes are protective against breast cancer in Taiwan. OMICS 13:165–172PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC. 2011

Authors and Affiliations

  • Liu Liu
    • 1
  • Fu-Zhou Hua
    • 2
  • Jia-Qing Cao
    • 1
  • Pei-Qian Zhu
    • 1
  1. 1.Department of Gastrointestinal SurgeryThe Second Affiliated Hospital of Nan Chang UniversityNanchang CityChina
  2. 2.Department of AnesthesiologyThe Second Affiliated Hospital of Nan Chang UniversityNanchang CityChina

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