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Breast Cancer Research and Treatment

, Volume 129, Issue 1, pp 117–124 | Cite as

Inflammatory breast cancer: high risk of contralateral breast cancer compared to comparably staged non-inflammatory breast cancer

  • Catherine Schairer
  • Linda M. Brown
  • Phuong L. Mai
Epidemiology

Abstract

Inflammatory breast cancer (IBC), the most lethal form of breast cancer, has characteristics linked to higher risk of contralateral breast cancer. However, no large studies have examined risk of contralateral breast cancer following IBC. We calculated absolute risk of invasive contralateral breast cancer among 5,631 IBC and 174,634 comparably staged non-IBC first breast cancer cases who survived at least 2 months following diagnosis and were reported to 13 Surveillance, Epidemiology, and End Results (SEER) registries between January 1, 1973 and December 31, 2006. We considered that contralateral cancers occurring within 2–23 months of first cancer diagnosis may more likely be metastatic/recurrent disease and those occurring 2 or more years after diagnosis independent primaries. Absolute risk of contralateral breast cancer was generally greater following IBC than regional/distant non-IBC, regardless of age and hormone receptor status of first cancer diagnosis. Much of the increase in absolute risk following IBC occurred within 2–23 months of first cancer diagnosis, while the risk for non-IBC occurred more gradually over time since diagnosis. For instance, among women first diagnosed before age 50, absolute risks following IBC and non-IBC were 4.9 vs. 1.1% at 2 years, 6.0 vs. 2.2% at 5 years, and 7.7 vs. 6.1% at 20 years after diagnosis. However, patterns of higher risk following IBC than non-IBC were also evident for at least 10–15 years in the subcohort of women who survived at least 24 months without a contralateral cancer. In conclusion, our results suggest that IBC has higher risk of cancer in the contralateral breast than comparably staged non-IBC, possibly due to both metastatic/recurrent disease and independent primaries.

Keywords

Inflammatory breast cancer Contralateral breast cancer Absolute risk 

Notes

Acknowledgments

The authors thank Nathan Appel at IMS, Inc. and David Check at the National Cancer Institute for computer support. This study was supported by the Intramural Research Program of the Division of Cancer Epidemiology and Genetics and contracts from the Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Department of Health and Human Services.

References

  1. 1.
    Anderson WF, Schairer C, Chen BE, Hance KW, Levine PH (2005–2006) Epidemiology of inflammatory breast cancer. Breast Dis 22:9–23Google Scholar
  2. 2.
    Bernstein JL, Lapinski RH, Thakore SS, Doucette JT, Thompson WD (2003) The descriptive epidemiology of second primary breast cancer. Epidemiology 14:522–558CrossRefGoogle Scholar
  3. 3.
    Berrington de Gonzalez A, Curtis RE, Gilbert E, Berg CD, Smith SA, Stovall M, Ron E (2010) Second solid cancers after radiotherapy for breast cancer in SEER cancer registries. Br J Cancer 102:220–226PubMedCrossRefGoogle Scholar
  4. 4.
    Kurian AW, McClure LA, John EM, Horn-Ross PL, Ford JM, Clarke CA (2009) Second primary breast cancer occurrence according to hormone receptor status. J Natl Cancer Inst 101:1058–1065PubMedCrossRefGoogle Scholar
  5. 5.
    Bouchardy C, Benhamou S, Fioretta G, Verkooijen HM, Chappuis PO, Neyroud-Caspar I, Castiglione M, Vinh-Hung V, Vlastos G, Rapiti E (2010) Risk of second breast cancer according to estrogen receptor status and family history. Breast Cancer Res Treat. Published online: 29 September 2010Google Scholar
  6. 6.
    Rubino C, Arriagada R, Delaloge S, Lê MG (2010) Relation of risk of contralateral breast cancer to the interval since the first primary tumor. Br J Cancer 102:213–219PubMedCrossRefGoogle Scholar
  7. 7.
    Imyanitov EN, Hanson KP (2003) Molecular pathogenesis of bilateral breast cancer. Cancer Lett 191:1–7PubMedCrossRefGoogle Scholar
  8. 8.
    Curtis RE, Freedman DM, Ron E, Ries LAG, Hacker DG, Edwards BK, Tucker MA, Fraumeni JF Jr (eds) (2006) New malignancies among cancer survivors: SEER Cancer Registries, 1973–2000. National Cancer Institute, NIH Publ. No. 05-5302, Bethesda, MDGoogle Scholar
  9. 9.
    Swain SM, Wilson JW, Mamounas EP, Bryant J, Wickerham D, Fisher B, Paik S, Wolmark N (2004) Estrogen receptor status of primary breast cancer is predictive of estrogen receptor status of contralateral breast cancer. J Natl Cancer Inst 96:516–523PubMedCrossRefGoogle Scholar
  10. 10.
    Banelli B, Casciano I, Di Vinci A, Gatteschi B, Levaggi A, Carli F, Bighin C, Salvi S, Allemanni G, Ghiorzo P, Pronzato P, Venturini M, Romani M, and Del Mastro L (2010) Pathological and molecular characteristics distinguishing contralateral metastatic from new primary breast cancer. Ann Oncol 21:1237–1242Google Scholar
  11. 11.
    Tuttle T, Habermann E, Abraham A, Emory T, Virnig B (2007) Contralateral prophylactic mastectomy for patients with unilateral breast cancer. Expert Rev Anticancer Ther 7:1117–1122PubMedCrossRefGoogle Scholar
  12. 12.
    Surveillance, Epidemiology, and End Results (SEER) Program (www.seer.cancer.gov) SEER*Stat Database: incidence—SEER 9 Regs Limited-Use, Nov 2007 Sub (1973–2005) <Katrina/Rita Population Adjustment>—Linked To County Attributes—Total U.S., 1969–2005 Counties, National Cancer Institute, DCCPS, Surveillance Research Program, Cancer Statistics Branch, Released April 2008, based on the November 2007 submission
  13. 13.
    Klein JP, Moeschberger ML (2003) Survival analysis: techniques for censored and truncated data. Springer Verlag, New York, pp 127–128Google Scholar
  14. 14.
    Software Citation: DevCan: Probability of Developing or Dying of Cancer Software, Version 6.5.0. Statistical Research and Applications Branch, National Cancer Institute, 2010. http://srab.cancer.gov/devcan
  15. 15.
    Online text is a revision of the text “Basic Human Anatomy” which was published in 1983 by W.B. Saunders. Copyright © O’Rahilly 2008 Author: Ronan O’Rahilly, MD. Site editor: Rand Swenson, DC, MD, PhD With: Fabiola Muller, Dr. rer. nat. and Stanley Carpenter, PhD Contributors: Brian Catlin, MD John Lyons, MD Dartmouth Medical SchoolGoogle Scholar
  16. 16.
    Van Laere S, Beissbarth T, Van der Auwera I, Van den Eynden G, Trinh XB, Elst H, Van Hummelen P, van Dam P, Van Marck E, Vermeulen P, Dirix L (2008) Relapse-free survival in breast cancer patients associated with a gene expression signature characteristic for inflammatory breast cancer. Clin Cancer Res 14:7452–7460PubMedCrossRefGoogle Scholar
  17. 17.
    Cristofanilli M, Valero V, Buzdar AU, Kau S-W, Broglio KR, Gonzalez-Angulo AM, Sneige N, Islam R, Ueno NT, Buchholz TA, Singletary SE, Hortobagyi GN (2007) Inflammatory breast cancer (IBC) and patterns of recurrence. Cancer 110:1436–1444PubMedCrossRefGoogle Scholar
  18. 18.
    Jaiyesimi IA, Buzdar AU, Hortobagyi G (1992) Inflammatory breast cancer: a review. J Clin Oncol 10:1014–1024PubMedGoogle Scholar
  19. 19.
    Bertucci F, Finetti P, Birnbaum D, Viens P (2010) Gene expression profiling of inflammatory breast cancer. Cancer 116(11 Suppl):2783–2793PubMedCrossRefGoogle Scholar
  20. 20.
    Dawood S, Merajver SD, Viens P, Vermeulen PB, Swain SM, Buchholz TA, Dirix LY, Levine PH, Lucci A, Krishnamurthy S, Robertson FM, Woodward WA, Yang WT, Ueno NT, Cristofanilli M (2011) International expert panel on inflammatory breast cancer: consensus statement for standardized diagnosis and treatment. Ann Oncol 22:515–523Google Scholar
  21. 21.
    Dawood S (2010) Biology and management of inflammatory breast cancer. Expert Rev Anticancer Ther 10:209–220PubMedCrossRefGoogle Scholar
  22. 22.
    EBCTCG (Early Breast Cancer Trialists’ Collaborative Group) (2005) Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: an overview of the randomized trials. Lancet 365:1687–1717CrossRefGoogle Scholar
  23. 23.
    Graeser MK, Engel C, Rhiem K, Gadzicki D, Bick U, Kast K, Froster UG, Schlehe B, Bechtold A, Arnold N, Preisler-Adams S, Nestle-Kraemling C, Zaino M, Loeffler M, Kiechle M, Meindl A, Varga D, Schmutzler RK (2009) Contralateral breast cancer risk in BRCA1 and BRCA2 mutation carriers. J Clin Oncol 27:5887–5892PubMedCrossRefGoogle Scholar
  24. 24.
    Largent JA, Capanu M, Bernstein L, Langholz B, Mellemkjaer L, Malone KE, Begg CB, Haile RW, Lynch CF, Anton-Culver H, Wolitzer A, Bernstein JL (2007) Reproductive history and risk of second primary breast cancer: the WECARE Study. Cancer Epidemiol Biomarkders Prev 16:906–911CrossRefGoogle Scholar
  25. 25.
    Figueiredo JC, Bernstein L, Capanu M, Malone KE, Lynch CF, Anton-Culver H, Stovall M, Bertelsen L, Haile RW, Bernstein JL (2008) Oral contraceptives, postmenopausal hormones, and risk of asynchronous bilateral breast cancer: the WECARE Study Group. J Clin Oncol 26:1411–1418PubMedCrossRefGoogle Scholar
  26. 26.
    Yang WT, Le-Petross HT, Macapinlac H, Carkaci S, Gonzalez-Angulo AM, Dawood S, Resetkova E, Hortobagyi GN, Cristofanilli M (2008) Inflammatory breast cancer: PET/CT, MRI, mammography, and sonography findings. Breast Cancer Res Treat 109:417–426PubMedCrossRefGoogle Scholar
  27. 27.
    Lostumbo L, Carbine NE, Wallace J, Ezzo J (2004) Prophylactic mastectomy for the prevention of breast cancer. Cochrane Database of Systematic Reviews, Issue 4. Art. No. CD002748. doi: 10.1002/14651858.CD002748.pub2

Copyright information

© Springer Science+Business Media, LLC (outside the USA)  2011

Authors and Affiliations

  • Catherine Schairer
    • 1
  • Linda M. Brown
    • 2
  • Phuong L. Mai
    • 1
  1. 1.Division of Cancer Epidemiology and Genetics, Department of Health and Human ServicesNational Cancer Institute, National Institutes of HealthRockvilleUSA
  2. 2.RTI InternationalRockvilleUSA

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