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Breast Cancer Research and Treatment

, Volume 125, Issue 3, pp 849–853 | Cite as

Association of a vascular endothelial growth factor gene 936 C/T polymorphism with breast cancer risk: a meta-analysis

  • Dae Sik Yang
  • Kyong Hwa Park
  • Ok Hee Woo
  • Sang Uk Woo
  • Ae-Ree Kim
  • Eun Sook Lee
  • Jae-Bok Lee
  • Yeul Hong Kim
  • Jun Suk Kim
  • Jae Hong Seo
Epidemiology

Abstract

Published studies on the association between the vascular endothelial growth factor (VEGF) gene 936 C/T polymorphism and breast cancer risk are inconclusive, and a meta-analysis is required to verify the association. Nine studies, including a total of 4,973 cases and 5,035 controls, were subjected to meta-analysis. When all eligible subjects were pooled for meta-analysis, the CT + TT genotypes were not associated with a significant decrease in breast cancer risk (odds ratio = 0.87; 95% confidence interval 0.75–1.02; P = 0.087). We also categorized by ethnicity (Caucasian, Asian, or mixed) for subgroup analysis, however, according to this subgroup analysis, we found no significant association between the CT and TT versus CC genotype with breast cancer risk reduction in any of the subgroups. We conclude that the VEGF gene 936 C/T polymorphism does not affect breast cancer risk.

Keywords

VEGF 936 C/T polymorphism Breast cancer risk Meta-analysis 

Notes

Acknowledgments

This study was supported by a grant of the Korean Health 21 R&D Project, Ministry of Health and Welfare, Republic of Korea (0412-CR01-0704-001).

Conflict of interest

None.

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Copyright information

© Springer Science+Business Media, LLC. 2010

Authors and Affiliations

  • Dae Sik Yang
    • 1
  • Kyong Hwa Park
    • 2
  • Ok Hee Woo
    • 3
  • Sang Uk Woo
    • 4
  • Ae-Ree Kim
    • 5
  • Eun Sook Lee
    • 4
  • Jae-Bok Lee
    • 4
  • Yeul Hong Kim
    • 2
  • Jun Suk Kim
    • 2
  • Jae Hong Seo
    • 2
  1. 1.Department of Radiation OncologyKorea University Guro HospitalSeoulKorea
  2. 2.Division of Medical Oncology, Department of Internal MedicineKorea University Guro HospitalSeoulKorea
  3. 3.Department of Diagnostic RadiologyKorea University Guro HospitalSeoulKorea
  4. 4.Department of SurgeryKorea University Guro HospitalSeoulKorea
  5. 5.Department of PathologyKorea University Guro HospitalSeoulKorea

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