Histologic diagnosis in young women with breast cancer
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Breast cancer is a heterogeneous group of tumors with similar diagnostic, but different prognostic profiles that can be subdivided on the basis of histopathological features, genetic alterations, and gene-expression profiles. The World Health Organization has defined a wide range of histopathological subtypes of invasive breast cancer and classified these carcinomas into 19 categories, most of which are quite rare . This classification into tumor subtypes is based on histopathological characteristics, and reflects differences in biological behavior and, in general lines, different outcomes. However, the main criticism to this classification is that >80% of the tumor subtypes is infiltrating ductal carcinomas not otherwise specified. For this reason, histologic grading systems, which do have prognostic value, have been elaborated.
Using an intrinsic set of 534 genes, Sorlie et al.  analyzed the expression profiles of 115 independent breast tumor samples and...
KeywordsBreast Cancer Epidermal Growth Factor Receptor Estrogen Receptor Luminal Trastuzumab
The authors acknowledge the support of Pfizer Spain, which facilitated the necessary meetings to evaluate and discuss all the data presented in this review, and Dr. Fernando Sánchez-Barbero from HealthCo SL (Madrid, Spain) for assistance in the preparation of this manuscript.
Conflict of Interest
The author has no conflict of interest.
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