The association between TA-repeat polymorphism in the promoter region of UGT1A1 and breast cancer risk: a meta-analysis
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Uridine diphospho-glucuronosyltransferase 1A1 (UGT1A1) plays an important role in breast cancer development. To date, many publications have evaluated the correlation between UGT1A1 TA-repeat polymorphism and breast cancer risk. However, the results remain inconclusive. In order to resolve this conflict, a meta-analysis was performed by searching Medline, PubMed, and ISI Web of Knowledge databases. Seven studies including 5,746 cases and 8,365 controls were collected for UGT1A1 TA-repeat polymorphism. The strength of association between UGT1A1 TA-repeat polymorphism and breast cancer risk was assessed by calculating crude ORs with 95% CIs. Overall, no significant associations between UGT1A1 TA-repeat polymorphism and breast cancer susceptibility were found. In the stratified analysis by ethnicity and source of controls, significant associations were only observed for 6/6 versus 7/7 (OR = 0.88; 95% CI: 0.77–0.99; P = 0.425 for heterogeneity) in Caucasians, but no in other genetic models. In conclusion, this meta-analysis suggests that UGT1A1 A(TA)7TAA allele is a potential risk factor for breast cancer in Caucasians.
KeywordsUGT1A1 Polymorphism Breast cancer Meta-analysis
This study was supported by national 973 programs of China grants 2004CB518605, the national 863 project of China grants 2006AA020501, and the national key sci-tech special project of China grants 2008ZX10002-020.
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