Breast Cancer Research and Treatment

, Volume 122, Issue 2, pp 495–501 | Cite as

Association between CYP19 polymorphisms and breast cancer risk: results from 10,592 cases and 11,720 controls



The association of CYP19 gene polymorphisms with breast cancer has been widely reported, but results of previous studies were somewhat contradictory and underpowered. In order to overcome the limitations of individual study and to understand the real situation, we conducted a systematic review and meta-analysis including three CYP19 gene polymorphisms [R264C polymorphism, CYP19_630 3-bp del/Ins polymorphism, and CYP19_681 (TTTA)n polymorphisms]. A total of 22 studies with 10,592 cases and 11,720 controls were identified, and the results showed that R264C polymorphism was not associated with breast cancer risk in overall (T vs. C: OR = 1.061, 95% CI = 0.929–1.212) or race-based populations (T vs. C for Asian: OR = 1.169, 95% CI = 1.002–1.363; for Caucasian: OR = 0.787, 95% CI = 0.597–1.037); meanwhile, for Asian individuals, 3-bpDel/Ins polymorphism showed a significantly association with breast cancer susceptibility (for allele Del vs. allele Ins: OR = 1.278, 95% CI = 1.066–1.532) while the carriers of allele (TTTA)12 can significantly decrease breast cancer risk (OR = 0.752, 95% CI = 0.603–0.939). Furthermore, the carriers of allele (TTTA)10 were significantly associated with breast cancer susceptibility (OR = 1.515, 95% CI = 1.115–2.058). It can be concluded that potentially functional CYP19_630 3-bp del/Ins polymorphism and CYP19_681 (TTTA)n polymorphisms may play a low penetrance role in breast cancer susceptibility in an ethnicity-specific manner.


CYP19 Aromatase Breast cancer Polymorphism Meta-analysis 



This work was not supported by any funds.


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Copyright information

© Springer Science+Business Media, LLC. 2010

Authors and Affiliations

  1. 1.Department of Epidemiology, Faculty of Preventive MedicineThird Military Medical UniversityChongqingChina
  2. 2.Breast Disease Center, Southwest HospitalThird Military Medical UniversityChongqingChina
  3. 3.Department of Occupational Health, Faculty of Preventive MedicineThird Military Medical UniversityChongqing400038China

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