Weight changes after adjuvant treatment in Korean women with early breast cancer
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Background Weight gain is a common problem in breast cancer patients and is reported to be associated with poorer survival. However, most data are limited to Western women. We evaluated weight changes after adjuvant treatment in Korean women with early breast cancer. Methods The authors reviewed the records of 260 patients with stage I–III breast cancer treated between June 2003 and February 2006. Body weight, body mass index (BMI) and menopausal status at baseline and after 3, 6, 12 and 24 months of adjuvant treatment were reviewed. Results Mean patient age was 47.0 years and 61.1% of women were premenopausal. Among them, 195 patients (75.8%) received chemotherapy and 186 (71.5%) received hormonal therapy. Mean baseline weight was 57.5 ± 9.8 kg and mean BMI was 23.5 ± 1.6 kg/m2 (22.8 ± 3.0 vs. 24.7 ± 3.2 kg/m2 for pre- vs. post-menopausal women, P = 0.286). Mean weight changes were; 0.30 kg at 3 months (P = 0.019); 0.16 kg at 6 months (P = 0.367); −0.34 kg at 1 year (P = 0.082); −0.40 kg at 2 years (P = 0.097). Twenty-three patients (10.4%) gained more than 5% of baseline body weight at 1 year, but no clinical variable was found to be associated with these weight gains. Conclusion This study shows that Korean women with early breast cancer do not gain weight after adjuvant treatment. Further studies are needed to determine differences between Asian and Western women in terms of weight changes and prognosis in early breast cancer.
KeywordsAdjuvant treatment Body mass index Breast cancer Chemotherapy Weight gain
This study was supported in part by a grant from the Korean Health 21 R&D Project, Ministry of Heath & Welfare, Republic of Korea (0412-CR01–0704-0001).
- 4.Demark-Wahnefried W, Peterson BL, Winter EP, Marks L, Aziz N, Marcom PK, Blackwell K, Rimer BK (2001) Changes in weight, body composition, and factors influencing energy balance among premenopausal breast cancer patients receiving adjuvant chemotherapy. J Clin Oncol 19(9):2381–2389PubMedGoogle Scholar
- 16.Brown J, Byers T, Thompson K, Eldridge B, Doyle C, Williams AM, American Cancer Society Workgroup on Nutrition, Physical Activity for Cancer Survivors (2001) Nutrition during and after cancer treatment: a guide for informed choices by cancer survivors. CA Cancer J Clin 51(3):153–187PubMedCrossRefGoogle Scholar
- 19.World Heath Organization (2000) Obesity: preventing and managing the global endemic. Report of a WHO Consultation. WHO Technical Report Series 894(3), i-253. WHO, GenevaGoogle Scholar
- 21.World Health Organization, International Association for the Study of Obesity, International Obesity Task Force (2000) The Asia-Pacific Perspective: redefining Obesity and its Treatment. Health Communications Australia Pty Ltd, Melbourne, AustraliaGoogle Scholar
- 25.Expert Panel on Detection, Evaluation, Treatment of High Blood Cholesterol in Adults (2001) Executive summary of the third report of the National Cholesterol Education Program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (adults treatment panel III). JAMA 285(19):2486–2497CrossRefGoogle Scholar
- 27.Saquib N, Flatt SW, Natarajan L, Thomson CA, Bardwell WA, Caan B, Rock CL, Pierce JP (2007) Weight gain and recovery of pre-cancer weight after breast cancer treatments: evidence from the women’s healthy eating and living (WHEL) study. Breast Cancer Res Treat 105(2):177–186PubMedCrossRefGoogle Scholar
- 32.Lankester KJ, Phillips JE, Lawton PA (2002) Weight gain during adjuvant and neoadjuvant chemotherapy for breast cancer: an audit of 100 women receiving FEC or CMF chemotherapy. Clin Oncol (R Coll Radiol) 14(1):64–67Google Scholar