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Breast Cancer Research and Treatment

, Volume 112, Issue 2, pp 359–361 | Cite as

Familial association of laryngeal, lung, stomach and early-onset breast cancer

  • Ewa Jaworowska
  • Pablo Serrano-Fernández
  • Czesława Tarnowska
  • Jakub Lubiński
  • Marek Brzosko
  • Jacek Flicinski
  • Bartołomej Masojc
  • Joanna Matyjasik
  • Rodney J. Scott
  • Steven A. Narod
  • Jan Lubiński
Epidemiology
  • 52 Downloads

Abstract

This study analyzes the incidence of different types of cancer among 2839 first-degree relatives of 760 consecutive, unselected laryngeal cancer patients, compared with the general population. A statistically significant excess was seen for other cancers of the larynx (SIR: 400), lung (SIR: 135) and stomach (SIR: 271), and early-onset breast cancer (SIR: 287). Familial laryngeal cancer may not be a single site-specific cancer syndrome.

Keywords

Breast Cancer Familial Laryngeal Larynx Lung Stomach 

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Copyright information

© Springer Science+Business Media, LLC. 2007

Authors and Affiliations

  • Ewa Jaworowska
    • 1
  • Pablo Serrano-Fernández
    • 2
  • Czesława Tarnowska
    • 1
  • Jakub Lubiński
    • 1
  • Marek Brzosko
    • 3
  • Jacek Flicinski
    • 3
  • Bartołomej Masojc
    • 2
  • Joanna Matyjasik
    • 2
  • Rodney J. Scott
    • 4
  • Steven A. Narod
    • 5
  • Jan Lubiński
    • 2
  1. 1.Department of Otolaryngology and Laryngological OncologyPomeranian Medical UniversitySzczecinPoland
  2. 2.Department of Genetics and Pathology, International Hereditary Cancer CenterPomeranian Medical UniversitySzczecinPoland
  3. 3.Faculty of Medicine, Department of RheumatologyPomeranian Medical UniversitySzczecinPoland
  4. 4.Faculty of Health, Discipline of Medical GeneticsUniversity of Newcastle and Hunter Medical Research InstituteNewcastleAustralia
  5. 5.Women’s College Research InstituteUniversity of TorontoTorontoCanada

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