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Breast Cancer Research and Treatment

, Volume 111, Issue 2, pp 219–228 | Cite as

Seasonal modulation of post-resection breast cancer metastasis

  • Eun-Young Oh
  • Patricia A. Wood
  • Jovelyn Du-Quiton
  • William J. M. Hrushesky
Preclinical Study

Abstract

Background Human breast cancer incidence, histopathologic grade, invasiveness, and mortality risk vary significantly throughout each year. In order to better understand this seasonal cancer biology, we investigated the circannual pattern of post-resection breast cancer metastasis, under genetically and environmentally controlled conditions. Methods Over a span of 14 consecutive years, we conducted 22 similar experiments to investigate metastatic biology of breast cancer among 1,214 C3HeB/FeJ female mice. All mice were kept in temperature-controlled environment with 12 h light:12 h dark photoperiod, with food and water freely available, from birth until death. At 10–13 weeks of age, each mouse received 20,000 viable syngeneic mammary cancer cells subcutaneously and the tumor bearing leg was resected 10–12 days after tumor inoculation for potential cure. Once 10% of resected mice were found moribund, due to autopsy proven pulmonary metastases, all remaining mice were sacrificed and metastatic lung nodules were counted. Results The incidence of post-resection pulmonary metastasis was not randomly distributed throughout the year, but peaked prominently in Summer and Winter. Although tumor volume at resection was strongly associated with metastatic potential, a significantly higher probability of pulmonary metastasis was observed if surgery was performed in Summer and Winter, regardless of tumor volume at resection, compared to Spring and Fall. Conclusion These results support the likelihood that human breast cancer seasonality is real and of biological origin. There are implications of this cancer chronobiology for breast cancer prevention, screening, diagnosis, and treatment.

Keywords

Seasonality Metastasis 

Notes

Acknowledgments

Principal Investigator (WJMH): Biologic Discrimination of Key Molecular Targets to Prevent Metastasis (VA MERIT) (through December 2006, $600,000). Principal Investigator: Clinical Application of Chronobiology to Cancer Medicine (NIH/NCI R01) (from 1979 to 2000, $3.5 million). Co-Principal Investigator (PAW): DVA Merit, Circadian Dependent Expression of Chemotherapy Response Genes (through 2004, $671,000).

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Copyright information

© Springer Science+Business Media, LLC. 2007

Authors and Affiliations

  • Eun-Young Oh
    • 1
    • 2
  • Patricia A. Wood
    • 1
    • 2
  • Jovelyn Du-Quiton
    • 1
    • 3
  • William J. M. Hrushesky
    • 1
    • 2
    • 3
    • 4
  1. 1.Medical Chronobiological Laboratory, Dorn Research InstituteWJB Dorn VA Medical CenterColumbiaUSA
  2. 2.School of MedicineUniversity of South CarolinaColumbiaUSA
  3. 3.School of Public HealthUniversity of South CarolinaColumbiaUSA
  4. 4.School of Computer Science and EngineeringUniversity of South CarolinaColumbiaUSA

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