Skip to main content

Advertisement

Log in

No association between BRCA mutations and sex ratio in offspring of Pakistani BRCA mutation carriers

  • Letter to the Editor
  • Published:
Breast Cancer Research and Treatment Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

References

  1. Claus EB, Schildkraut JM, Thompson WD, Risch NJ (1996) The genetic attributable risk of breast and ovarian cancer. Cancer 77:2318–2324

    Article  PubMed  CAS  Google Scholar 

  2. Rebbeck TR, Couch FJ, Kant J, Calzone K, DeShano M, Peng Y, Chen K, Garber JE, Weber BL (1996) Genetic heterogeneity in hereditary breast cancer: role of BRCA1 and BRCA2. Am J Hum Genet 59:547–553

    PubMed  CAS  Google Scholar 

  3. Venkitaraman AR (2002) Cancer susceptibility and the functions of BRCA1 and BRCA2. Cell 08:171–182

    Article  Google Scholar 

  4. De la Hoya M, Fernandez JM, Tosar A, Godino J, Sanchez de Abajo A, Vidart JA, Perez-Segura P, Diaz-Rubio E, Caldes T (2003) Association between BRCA1 mutations and ratio of female to male births in offspring of families with breast cancer, ovarian cancer, or both. JAMA 290:929–931

    Article  Google Scholar 

  5. Gronwald J, Gorski B, Byrski T, Huzarski T, Jakubowska A, Menkiszak J, Narod SA, Lubinski J (2003) Non-random transmission of mutant alleles to female offspring of BRCA1 carriers in Poland. J Med Genet 40:719–720

    Article  PubMed  CAS  Google Scholar 

  6. Feunteun J, Chompret A, Helbling-Leclerc A, Stoppa-Lyonnet D, Belotti M, Nogues C, Bonaiti-Pellie C (2004) Sex ratio among the offspring of BRCA mutation carriers. JAMA 292:687–688

    Article  PubMed  CAS  Google Scholar 

  7. Kotar K, Brunet JS, Moller P, Hugel L, Warner E, McLaughlin J, Wong N, Narod SA, Foulkes WD (2004) Ratio of female to male offspring of women tested for BRCA1 and BRCA2 mutations. J Med Genet 41:e103

    Article  PubMed  CAS  Google Scholar 

  8. Gal I, Sadetzki S, Gershoni-Baruch R, Oberman B, Carp H, Papa MZ, Diestelman-Menachem T, Eisenberg-Barzilai S, Friedman E (2004) Offspring gender ratio and the rate of recurrent spontaneous miscarriages in Jewish women at high risk for breast/ovarian cancer. Am J Hum Genet 74:1270–1275

    Article  PubMed  CAS  Google Scholar 

  9. Struewing JP, Hartge P, Wacholder S, Tucker MA, Greene MH (2004) BRCA1 and sex ratio. Eur J Hum Genet 12:663–667

    Article  PubMed  CAS  Google Scholar 

  10. Balmana J, Diez O, Campos B, Majewski M, Sanz J, Alonso C, Baiget M, Garber JE (2005) Sex ratio distortion in offspring of families with BRCA1 or BRCA2 mutant alleles: an ascertainment bias phenomenon? Breast Cancer Res Treat 92:273–277

    Article  PubMed  CAS  Google Scholar 

  11. Chenevix-Trench G, Sinilnikova OM, Suthers G, Pandeya N, Mazoyer S, Sambrook JF, Goldup S, Goldgar D, Lynch HT, Lenoir GM, Cheetham G, kConFab (2005) Ratio of male to female births in the offspring of BRCA1 and BRCA2 carriers. Fam Cancer 4:73–75

  12. Domchek SM, Merillat SL, Tigges J, Tweed AJ, Weinar M, Stopfer J, Weber BL (2005) Sex ratio skewing of offspring in families with hereditary susceptibility to breast cancer. J Med Genet 42:511–513

    Article  PubMed  CAS  Google Scholar 

  13. Evans DG, Shenton A, Sharif S, Woodward E, Lalloo F, Maher ER (2005) Non-random transmission of mutant alleles to female offspring in BRCA carriers. J Med Genet 42:e6

    Article  PubMed  CAS  Google Scholar 

  14. Gronwald J, Byrski T, Huzarski T, Narod SA, Lubinski J (2006) Male to female ratio among offspring of BRCA1 mutation carriers. Breast Cancer Res Treat 97:113–114

    Article  PubMed  Google Scholar 

  15. Rashid MU, Zaidi A, Torres D, Sultan F, Benner A, Naqvi B, Shakoori AR, Seidel-Renkert A, Farooq H, Narod S, Amin A, Hamann U (2006) Prevalence of BRCA1 and BRCA2 mutations in Pakistani breast and ovarian cancer patients. Int J Cancer 119:2832–2839

    Article  PubMed  CAS  Google Scholar 

  16. Mealiffe ME (2003) Sex ratios in families with BRCA mutations. JAMA 290:2544–2545

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Ute Hamann.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Rashid, M.U., Torres, D., Zaidi, A. et al. No association between BRCA mutations and sex ratio in offspring of Pakistani BRCA mutation carriers. Breast Cancer Res Treat 107, 155–156 (2008). https://doi.org/10.1007/s10549-007-9521-z

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10549-007-9521-z

Keywords

Navigation