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Breast Cancer Research and Treatment

, Volume 107, Issue 1, pp 155–156 | Cite as

No association between BRCA mutations and sex ratio in offspring of Pakistani BRCA mutation carriers

  • Muhammad U. Rashid
  • Diana Torres
  • Anbreen Zaidi
  • Farah Rasheed
  • Faisal Sultan
  • Abdul R. Shakoori
  • Asim Amin
  • Ute Hamann
Letter to the Editor

Keywords

BRCA1/2 Germ line mutations Sex ratio Hereditary breast/ovarian cancer Pakistan 

References

  1. 1.
    Claus EB, Schildkraut JM, Thompson WD, Risch NJ (1996) The genetic attributable risk of breast and ovarian cancer. Cancer 77:2318–2324PubMedCrossRefGoogle Scholar
  2. 2.
    Rebbeck TR, Couch FJ, Kant J, Calzone K, DeShano M, Peng Y, Chen K, Garber JE, Weber BL (1996) Genetic heterogeneity in hereditary breast cancer: role of BRCA1 and BRCA2. Am J Hum Genet 59:547–553PubMedGoogle Scholar
  3. 3.
    Venkitaraman AR (2002) Cancer susceptibility and the functions of BRCA1 and BRCA2. Cell 08:171–182CrossRefGoogle Scholar
  4. 4.
    De la Hoya M, Fernandez JM, Tosar A, Godino J, Sanchez de Abajo A, Vidart JA, Perez-Segura P, Diaz-Rubio E, Caldes T (2003) Association between BRCA1 mutations and ratio of female to male births in offspring of families with breast cancer, ovarian cancer, or both. JAMA 290:929–931CrossRefGoogle Scholar
  5. 5.
    Gronwald J, Gorski B, Byrski T, Huzarski T, Jakubowska A, Menkiszak J, Narod SA, Lubinski J (2003) Non-random transmission of mutant alleles to female offspring of BRCA1 carriers in Poland. J Med Genet 40:719–720PubMedCrossRefGoogle Scholar
  6. 6.
    Feunteun J, Chompret A, Helbling-Leclerc A, Stoppa-Lyonnet D, Belotti M, Nogues C, Bonaiti-Pellie C (2004) Sex ratio among the offspring of BRCA mutation carriers. JAMA 292:687–688PubMedCrossRefGoogle Scholar
  7. 7.
    Kotar K, Brunet JS, Moller P, Hugel L, Warner E, McLaughlin J, Wong N, Narod SA, Foulkes WD (2004) Ratio of female to male offspring of women tested for BRCA1 and BRCA2 mutations. J Med Genet 41:e103PubMedCrossRefGoogle Scholar
  8. 8.
    Gal I, Sadetzki S, Gershoni-Baruch R, Oberman B, Carp H, Papa MZ, Diestelman-Menachem T, Eisenberg-Barzilai S, Friedman E (2004) Offspring gender ratio and the rate of recurrent spontaneous miscarriages in Jewish women at high risk for breast/ovarian cancer. Am J Hum Genet 74:1270–1275PubMedCrossRefGoogle Scholar
  9. 9.
    Struewing JP, Hartge P, Wacholder S, Tucker MA, Greene MH (2004) BRCA1 and sex ratio. Eur J Hum Genet 12:663–667PubMedCrossRefGoogle Scholar
  10. 10.
    Balmana J, Diez O, Campos B, Majewski M, Sanz J, Alonso C, Baiget M, Garber JE (2005) Sex ratio distortion in offspring of families with BRCA1 or BRCA2 mutant alleles: an ascertainment bias phenomenon? Breast Cancer Res Treat 92:273–277PubMedCrossRefGoogle Scholar
  11. 11.
    Chenevix-Trench G, Sinilnikova OM, Suthers G, Pandeya N, Mazoyer S, Sambrook JF, Goldup S, Goldgar D, Lynch HT, Lenoir GM, Cheetham G, kConFab (2005) Ratio of male to female births in the offspring of BRCA1 and BRCA2 carriers. Fam Cancer 4:73–75Google Scholar
  12. 12.
    Domchek SM, Merillat SL, Tigges J, Tweed AJ, Weinar M, Stopfer J, Weber BL (2005) Sex ratio skewing of offspring in families with hereditary susceptibility to breast cancer. J Med Genet 42:511–513PubMedCrossRefGoogle Scholar
  13. 13.
    Evans DG, Shenton A, Sharif S, Woodward E, Lalloo F, Maher ER (2005) Non-random transmission of mutant alleles to female offspring in BRCA carriers. J Med Genet 42:e6PubMedCrossRefGoogle Scholar
  14. 14.
    Gronwald J, Byrski T, Huzarski T, Narod SA, Lubinski J (2006) Male to female ratio among offspring of BRCA1 mutation carriers. Breast Cancer Res Treat 97:113–114 PubMedCrossRefGoogle Scholar
  15. 15.
    Rashid MU, Zaidi A, Torres D, Sultan F, Benner A, Naqvi B, Shakoori AR, Seidel-Renkert A, Farooq H, Narod S, Amin A, Hamann U (2006) Prevalence of BRCA1 and BRCA2 mutations in Pakistani breast and ovarian cancer patients. Int J Cancer 119:2832–2839PubMedCrossRefGoogle Scholar
  16. 16.
    Mealiffe ME (2003) Sex ratios in families with BRCA mutations. JAMA 290:2544–2545PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2007

Authors and Affiliations

  • Muhammad U. Rashid
    • 1
    • 2
  • Diana Torres
    • 2
  • Anbreen Zaidi
    • 1
  • Farah Rasheed
    • 1
  • Faisal Sultan
    • 1
  • Abdul R. Shakoori
    • 3
  • Asim Amin
    • 4
  • Ute Hamann
    • 2
  1. 1.Shaukat Khanum Memorial Cancer Hospital and Research CentreLahorePakistan
  2. 2.Division of Molecular Genome AnalysisGerman Cancer Research CenterHeidelbergGermany
  3. 3.University of the PunjabLahorePakistan
  4. 4.Blumenthal Cancer Centre, Carolinas Medical CentreCharlotteUSA

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